The Clinical Knowledgebase (CKB)

Powered by The Jackson Laboratory

CKB is a dynamic digital resource for interpreting complex cancer genomic profiles in the context of protein impact, therapies, and clinical trials. CKB CORE is the public access version we have been providing to the community since 2016. CKB CORE contains all the content associated with 50 genes that are commonly found on cancer hotspot panels. New and updated content is pushed out daily and viewable genes are available on a quarterly rotating schedule.

Basic Search
Explore by Gene Explore by Variant Explore by DrugClass - Available in CKB BOOST Explore by Drug - Available in CKB BOOST Explore by Indication/Tumor Type - Available in CKB BOOST
Advanced Search
Clinical Trial Search - Available in CKB BOOST Evidence Search - Available in CKB BOOST
Check out   CKB BOOST for content extending to 2000+ genes.

News
Apr 15, 2024 - It's time for the gene quarterly update, CKB CORE users! This quarter you'll see the genes related to DNA repair. For more information on this set of genes, check out the newsletter to learn more! As always, if you have any questions or comments, please feel free to reach out to us at ckbsupport@jax.org!