Gene Detail
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| Gene Symbol | FBXO2 | ||||||||||
| Synonyms | FBG1 | Fbs1 | FBX2 | NFB42 | OCP1 | ||||||||||
| Gene Description | FBXO2, F-box protein 2, encodes a component of the E3 ubiquitin ligase complex that mediates the ubiquitination and degradation of target glycoproteins (PMID: 26460611, PMID: 32549792), including those involved in regulating cell proliferation and migration (PMID: 29269301, PMID: 32984335). Overexpression of Fbxo2 has been identified in endometrial carcinoma (PMID: 32984335), and has been associated with increased metastasis in gastric (PMID: 29269301) and colorectal cancer (PMID: 31949582). | ||||||||||
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