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| Gene Symbol | DPH3 | ||||||||||
| Synonyms | DELGIP | DELGIP1 | DESR1 | DPH3A | KTI11 | ZCSL2 | ||||||||||
| Gene Description | DPH3, diphthamide biosynthesis 3, encodes a zinc finger protein involved in dipthamide synthesis, which involves modification to the elongater complex, specifically converting a histidine residue to dipthamide in the eukaryotic elongation factor 2 protein (PMID: 16648478, PMID: 28555368). DPH3 mutations in the promoter region have been identified in various skin cancers, including melanoma, basal cell carcinoma, and squamous cell carcinoma (PMID: 26416425). | ||||||||||
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