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| Gene Symbol | MTAP | ||||||||||
| Synonyms | BDMF | c86fus | DMSFH | DMSMFH | HEL-249 | LGMBF | MSAP | ||||||||||
| Gene Description | MTAP, methylthioadenosine phosphorylase, encodes an enzyme that plays a role in the methionine salvage pathway via catalyzing methylthioadenosine (MTA), a product of polyamine biosynthesis, and results in salvaging adenine and methionine (PMID: 26751376, PMID: 24324622). Loss of MTAP frequently occurs in a variety of tumors, including glioma (PMID: 32093414) lung cancer (PMID: 31965001), and malignant pleural mesothelioma (PMID: 31231127), which may result in an accumulation of MTA, leading to deregulation of cellular pathways (PMID: 27068473, PMID: 26819315). | ||||||||||
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