Gene Detail
Contact
Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@jax.org
| Gene Symbol | DEPTOR | ||||||||||
| Synonyms | DEP.6 | DEPDC6 | hDEPTOR | ||||||||||
| Gene Description | DEPTOR, DEP domain containing MTOR-interacting protein, is an mTOR binding protein that negatively regulates signaling by mTORC1 and mTORC2 (PMID: 19446321, PMID: 29897294). Aberrant expression of Deptor has been observed in a variety of tumor types, but a recent meta-analysis shows Deptor expression does not correlate with prognosis (PMID: 30174446), however, it may be invloved in chemoresistance (PMID: 28267437, PMID: 31710966) and is a putative tumor suppressor in prostate cancer (PMID: 31685947). | ||||||||||
|
|||||||||||
Additional content available in 
CKB BOOST
CKB BOOST
