Gene Detail
Contact
Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@jax.org
| Gene Symbol | AIM2 | ||||||||||
| Synonyms | PYHIN4 | ||||||||||
| Gene Description | AIM2, absent in melanoma 2, is an immune receptor that recognizes dsDNA shed during breakage (PMID: 31372985) to regulate assembly of the inflammasome, and induces apoptosis, and prevents proliferation of tumor cells (PMID: 21804607, PMID: 28243117). Loss of Aim2 expression has been observed in liver cancer (PMID: 27167192), results in Akt activation in colorectal cancer (PMID: 26107252, PMID: 28243117), may be prognostic for poor outcomes in renal cell carcinoma (PMID: 30031129), and is overexpressed in glioblastoma (PMID: 31280432). | ||||||||||
|
|||||||||||
Additional content available in 
CKB BOOST
CKB BOOST
