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Gene | PALB2 |
Variant | dec exp |
Impact List | none |
Protein Effect | no effect |
Gene Variant Descriptions | PALB2 dec exp indicates decreased expression of the Palb2 protein and/or mRNA. However, the mechanism causing the decreased expression is unspecified. |
Associated Drug Resistance | |
Category Variants Paths |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PALB2 dec exp | triple-receptor negative breast cancer | sensitive | SN30000 | Preclinical | Actionable | In a preclinical study, knockdown of PALB2 enhanced growth inhibition by SN30000 in triple-negative breast cancer cell lines in culture (PMID: 25193512). | 25193512 |
PALB2 dec exp | triple-receptor negative breast cancer | sensitive | PR-104 | Preclinical | Actionable | In a preclinical study, knockdown of PALB2 enhanced growth inhibition by PR-104 in triple-negative breast cancer cell lines in culture (PMID: 25193512). | 25193512 |
PALB2 dec exp | triple-receptor negative breast cancer | sensitive | Evofosfamide | Preclinical | Actionable | In a preclinical study, knockdown of PALB2 enhanced growth inhibition by Evofosfamide (TH-302) in triple-negative breast cancer cell lines in culture (PMID: 25193512). | 25193512 |
PALB2 dec exp | triple-receptor negative breast cancer | sensitive | Chlorambucil | Preclinical | Actionable | In a preclinical study, knockdown of PALB2 enhanced growth inhibition by Ambochlorin (chlorambucil) in triple-negative breast cancer cell lines in culture (PMID: 25193512). | 25193512 |
PALB2 dec exp | triple-receptor negative breast cancer | sensitive | Cisplatin | Preclinical | Actionable | In a preclinical study, knockdown of PALB2 enhanced growth inhibition by Platinol (cisplatin) in triple-negative breast cancer cell lines in culture (PMID: 25193512). | 25193512 |