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| NCT ID | NCT02187783 |
| Title | LEE011 for Patients With CDK4/6 Pathway Activated Tumors (SIGNATURE) |
| Acronym | SIGNATURE |
| Recruitment | Completed |
| Gender | both |
| Phase | Phase II |
| Variant Requirements | Yes |
| Sponsors | Novartis Pharmaceuticals |
| Indications | |
| Therapies | |
| Age Groups: | adult |
| Covered Countries | USA |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35249 | United States | Details | |
| Alaska Clinical Research | Anchorage | Alaska | 99503 | United States | Details | |
| Arizona Oncology Associates Dept. Of Onc. | Phoenix | Arizona | United States | Details | ||
| University of Arkansas/ Arkansas Cancer Research Center UA Medical Sciences | Little Rock | Arkansas | 72205 | United States | Details | |
| PCR Oncology | Pismo Beach | California | 93449 | United States | Details | |
| University of California Davis Cancer Center UC Davis Cancer (3) | Sacramento | California | 95817 | United States | Details | |
| Sarah Cannon Research Institute | Denver | Colorado | 80218 | United States | Details | |
| Danbury Hospital | Danbury | Connecticut | 06810 | United States | Details | |
| Yale University School of Medicine Smilow Cancer Hospital | New Haven | Connecticut | 06520 | United States | Details | |
| Whittingham Cancer Center Norwalk Hospital | Norwalk | Connecticut | 06856 | United States | Details | |
| Stamford Hospital Med. Oncology Hematology Res. | Stamford | Connecticut | 06902 | United States | Details | |
| Florida Hospital Cancer Institute | Orlando | Florida | 32804 | United States | Details | |
| NorthWest Georgia Oncology Centers NW Georgia Oncology | Marietta | Georgia | 30060 | United States | Details | |
| Harbin Clinic Medical Oncology Clin. Res. | Rome | Georgia | 30165 | United States | Details | |
| Queen's Medical Center Queens Cancer Center | Honolulu | Hawaii | 96817 | United States | Details | |
| Northwestern Medicine Developmental Therapeutics Institute | Chicago | Illinois | 60611 | United States | Details | |
| Indiana University Indiana Univ. - Purdue Univ. | Indianapolis | Indiana | 46202 | United States | Details | |
| Northern Indiana Cancer Research Consortium No. Indiana Cancer Res. | South Bend | Indiana | 46617 | United States | Details | |
| University of Iowa Hospitals & Clinics Regulatory Contact 2 | Iowa City | Iowa | 52242 | United States | Details | |
| New England Cancer Specialists | Scarborough | Maine | 04074 | United States | Details | |
| St. Agnes Hospital St. Agnes Hospital (2) | Baltimore | Maryland | 21229 | United States | Details | |
| Michigan Medicine University of Michigan Int. Medicine Oncology | Ann Arbor | Michigan | 48109 5271 | United States | Details | |
| Cancer and Hematology Centers of West Michigan Dept. of Oncology | Grand Rapids | Michigan | 49546 | United States | Details | |
| Saint Luke's Hospital/Marion Bloch Neuroscience Institute St. Luke's Hospital (4) | Kansas City | Missouri | 64111 | United States | Details | |
| Research Medical Center Research Med Center (2) | Kansas City | Missouri | 64132 | United States | Details | |
| Comprehensive Cancer Centers of Nevada CCC of Nevada- Southwest (2) | Las Vegas | Nevada | 89109 | United States | Details | |
| Cooper Health System Cooper Health System (5) | Camden | New Jersey | 08103 | United States | Details | |
| Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey | 08903 | United States | Details | |
| New Mexico Cancer Care Alliance | Albuquerque | New Mexico | 87106 | United States | Details | |
| Cancer Center at Presbyterian | Albuquerque | New Mexico | United States | Details | ||
| Broome Oncology Broome Oncology (2) | Johnson City | New York | 13790 | United States | Details | |
| University of N C at Chapel Hill Physician Office Building | Chapel Hill | North Carolina | 27599-7600 | United States | Details | |
| Carolina Oncology Specialists, PC | Hickory | North Carolina | 28602 | United States | Details | |
| Wake Forest University Baptist Medical Center | Winston-Salem | North Carolina | 27157 | United States | Details | |
| Oncology Hematology Care Inc Oncology Hematology Care 2 | Cincinnati | Ohio | 45242 | United States | Details | |
| Cleveland Clinic Foundation Taussig Cancer Institute | Cleveland | Ohio | 44195 | United States | Details | |
| Ohio State University Medical Center Comprehensive Cancer Center | Columbus | Ohio | 43221 | United States | Details | |
| Oregon Health and Science University Oregon Health & Science U (56) | Portland | Oregon | 97239 | United States | Details | |
| Salem Health | Salem | Oregon | 97309 | United States | Details | |
| Fox Chase Cancer Center Dept of Medical Oncology | Philadelphia | Pennsylvania | 19111 | United States | Details | |
| Rhode Island Hospital Rhode Island Hosp. (2) | Providence | Rhode Island | 02903 | United States | Details | |
| Greenville Health System ITOR - Cancer Institute | Greenville | South Carolina | 29615 | United States | Details | |
| Sanford University of South Dakota Medical Center Sanford Health | Sioux Falls | South Dakota | 57104 | United States | Details | |
| Chattanooga Oncology and Hematology Assoicates, PC Chattanooga Oncology | Chattanooga | Tennessee | 37404 | United States | Details | |
| The West Clinic Dept. of the West Clinic | Memphis | Tennessee | 38120 | United States | Details | |
| Tennessee Oncology Tennessee Oncology (3) | Nashville | Tennessee | 37203 | United States | Details | |
| Coastal Bend Cancer Center | Corpus Christi | Texas | 78404 | United States | Details | |
| Oncology Consultants Oncology Group | Houston | Texas | 77024 | United States | Details | |
| MD Anderson Cancer Center/University of Texas MD Anderson Cancer Center (3) | Houston | Texas | 77030 | United States | Details | |
| University of Texas Health Science Center at San Antonio Cancer Therapy & Research Ctr. | San Antonio | Texas | 78229 | United States | Details | |
| Intermountain Medical Center Intermountain Healthcare | Murray | Utah | 84157 | United States | Details | |
| Utah Cancer Specialists Utah Cancer Specialists (11) | Salt Lake City | Utah | 84106 | United States | Details | |
| Shenandoah Oncology Shenadoah Oncology (2) | Winchester | Virginia | 22601 | United States | Details | |
| Kadlec Clinic Hematology and Oncology Kadlec Clinic Hematology & Onc | Kennewick | Washington | 99336 | United States | Details | |
| Vista Oncology Inc. PS | Olympia | Washington | 98502 | United States | Details | |
| Multicare Research Institute | Tacoma | Washington | 98405 | United States | Details | |
| Northwest Medical Specialties Rainier Physicians, PC | Tacoma | Washington | 98405 | United States | Details | |
| Providence St. Mary Regional Cancer Center | Walla Walla | Washington | 98057 | United States | Details | |
| Wenatchee Valley Medical Center Wenatchee Valley | Wenatchee | Washington | 98801 | United States | Details | |
| Aurora Research Institute Aurora Health Care | Milwaukee | Wisconsin | 53226 | United States | Details | |
| Medical College of Wisconsin Cancer Center | Milwaukee | Wisconsin | 53226 | United States | Details |