Clinical Trial Detail


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NCT ID NCT02457598
Title Dose Escalation and Dose Expansion Study of Tirabrutinib in Combination With Other Targeted Anti-cancer Therapies in Adults With B-cell Malignancies
Recruitment Active, not recruiting
Gender both
Phase Phase I
Variant Requirements No
Sponsors Gilead Sciences

marginal zone B-cell lymphoma

chronic lymphocytic leukemia/small lymphocytic lymphoma

B-cell lymphoma

chronic lymphocytic leukemia

Waldenstroem's macroglobulinemia

mantle cell lymphoma

diffuse large B-cell lymphoma

follicular lymphoma


Entospletinib + Tirabrutinib


Idelalisib + Obinutuzumab + Tirabrutinib

Entospletinib + Obinutuzumab + Tirabrutinib

Idelalisib + Tirabrutinib

Age Groups: adult | senior
Covered Countries USA | FRA

Facility Status City State Zip Country Details
Georgetown University Medical Center Washington District of Columbia 20007 United States Details
Indiana University Health Goshen Center for Cancer Care Goshen Indiana 46506 United States Details
Oregon Health and Science University Portland Oregon 97239 United States Details
CHRU de Lille, Hopital Claude Huriez Lille 59037 France Details
Hopital Saint Eloi Montpellier 34295 France Details
Chu Haut Leveque Pessac 33604 France Details
Centre Hospitalier de Lyon Sud Pierre Benite 69310 France Details
Institut Universitaire du Cancer-Oncopole I.U.C.T-O Toulouse 3110 France Details
Cambridge University Hospitals NHS Foundation Trust Cambridge CB20QQ United Kingdom Details
Cardiff and Vale Health Board, Clinical Research Facility Cardiff CF14 4XW United Kingdom Details
Leeds Teaching Hosptials NHS Trust, Dept of Haematology Leeds LS9 7TF United Kingdom Details
University Hospitals of Leicester NHS Trust Leicester LE1 5WW United Kingdom Details
The Christie NHS Foundation Trust Manchester M20 4BX United Kingdom Details
Plymouth Hospitals NHS Trust Plymouth PL68DH United Kingdom Details
University Hospital Southampton NHS Foundation Trust Southampton SO16 6YD United Kingdom Details
*Shaded cells indicate that there was no data available from for the field