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| NCT ID | NCT02538666 |
| Title | A Randomized, Multicenter, Double-Blind, Phase 3 Study of Nivolumab, Nivolumab in Combination With Ipilimumab, or Placebo as Maintenance Therapy in Subjects With Extensive-Stage Disease Small Cell Lung Cancer (ED-SCLC) After Completion of Platinum-based First Line Chemotherapy (CheckMate 451) |
| Acronym | CheckMate 451 |
| Recruitment | Completed |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Bristol-Myers Squibb |
| Indications | |
| Therapies | |
| Age Groups: | adult |
| Covered Countries | USA | NLD | ITA | GBR | FRA | ESP | DEU | CAN | BEL | AUT | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Local Institution - 0003 | Sacramento | California | 95816 | United States | Details | |
| Local Institution - 0202 | New Haven | Connecticut | 06520 | United States | Details | |
| Local Institution - 0127 | Fort Myers | Florida | 33901 | United States | Details | |
| Local Institution - 0007 | Jacksonville | Florida | 32256 | United States | Details | |
| Local Institution - 0128 | Saint Petersburg | Florida | 33705 | United States | Details | |
| Local Institution - 0010 | Atlanta | Georgia | 30322 | United States | Details | |
| Local Institution - 0013 | Indianapolis | Indiana | 46237 | United States | Details | |
| Local Institution - 0061 | Fairway | Kansas | 66205 | United States | Details | |
| Local Institution - 0012 | Wichita | Kansas | 67214 | United States | Details | |
| Local Institution - 0032 | Lexington | Kentucky | 40503 | United States | Details | |
| Local Institution - 0051 | Baltimore | Maryland | 21287 | United States | Details | |
| Local Institution - 0107 | Boston | Massachusetts | 02215 | United States | Details | |
| Local Institution - 0207 | Boston | Massachusetts | 02215 | United States | Details | |
| Local Institution - 0015 | Saint Louis | Missouri | 63110 | United States | Details | |
| Local Institution - 0008 | New York | New York | 10065 | United States | Details | |
| Local Institution - 0014 | Durham | North Carolina | 27710 | United States | Details | |
| Local Institution - 0016 | Winston-Salem | North Carolina | 27103 | United States | Details | |
| Local Institution - 0215 | Fargo | North Dakota | 58102 | United States | Details | |
| Local Institution - 0129 | Cincinnati | Ohio | 45242 | United States | Details | |
| Local Institution - 0009 | Columbus | Ohio | 43210 | United States | Details | |
| Local Institution - 0001 | Portland | Oregon | 97213 | United States | Details | |
| Local Institution - 0034 | Portland | Oregon | 97239 | United States | Details | |
| Local Institution - 0004 | Allentown | Pennsylvania | 18103 | United States | Details | |
| Local Institution - 0002 | Sayre | Pennsylvania | 18840 | United States | Details | |
| Local Institution - 0005 | Charleston | South Carolina | 29425 | United States | Details | |
| Local Institution - 0213 | Sioux Falls | South Dakota | 57104 | United States | Details | |
| Local Institution - 0011 | Salt Lake City | Utah | 84112 | United States | Details | |
| Local Institution - 0006 | Richmond | Virginia | 23226 | United States | Details | |
| Local Institution - 0110 | Berazategui | Buenos Aires | 1880 | Argentina | Details | |
| Local Institution - 0088 | Capital Federal | Buenos Aires | 1426 | Argentina | Details | |
| Local Institution - 0109 | Ciudad Autonoma De Buenos Aire | Buenos Aires | 1181 | Argentina | Details | |
| Local Institution - 0188 | Cordoba | 5004 | Argentina | Details | ||
| Local Institution - 0029 | Tucuman | 4000 | Argentina | Details | ||
| Local Institution | Kogarah | New South Wales | Australia | Details | ||
| Local Institution | Wollongong | New South Wales | 2500 | Australia | Details | |
| Local Institution | Birtinya | Queensland | 4575 | Australia | Details | |
| Princess Alexandra Hospital | Brisbane | Queensland | 4102 | Australia | Details | |
| Local Institution - 0137 | Adelaide | South Australia | 5000 | Australia | Details | |
| Local Institution - 0035 | East Melbourne | Victoria | 3165 | Australia | Details | |
| Local Institution - 0174 | Innsbruck | 6020 | Austria | Details | ||
| Local Institution - 0173 | Salzburg | 5020 | Austria | Details | ||
| Local Institution - 0172 | Wien | 1130 | Austria | Details | ||
| Local Institution - 0057 | Brussels | 1090 | Belgium | Details | ||
| Local Institution - 0059 | Charleroi | 6000 | Belgium | Details | ||
| Local Institution - 0060 | Roeselare | 8800 | Belgium | Details | ||
| Local Institution - 0067 | Fortaleza | Ceara | 60430-230 | Brazil | Details | |
| Local Institution - 0068 | Belo Horizonte | Minas Gerais | 30110-022 | Brazil | Details | |
| Local Institution - 0063 | Ijui | RIO Grande DO SUL | 98700-000 | Brazil | Details | |
| Local Institution - 0064 | Porto Alegre | RIO Grande DO SUL | 90610000 | Brazil | Details | |
| Local Institution - 0017 | Itajai | Santa Catarina | 88301-220 | Brazil | Details | |
| Local Institution - 0081 | Barretos | Sao Paulo | 14784-400 | Brazil | Details | |
| Local Institution | Rio de Janeiro | 22793-080 | Brazil | Details | ||
| Local Institution | Salvador | 40170-110 | Brazil | Details | ||
| Local Institution - 0094 | Edmonton | Alberta | T6G 1Z2 | Canada | Details | |
| Local Institution - 0136 | Moncton | New Brunswick | E1C 6Z8 | Canada | Details | |
| Local Institution - 0123 | Oshawa | Ontario | L1G 2B9 | Canada | Details | |
| Local Institution - 0102 | Sudbury | Ontario | P3E 5J1 | Canada | Details | |
| Local Institution - 0111 | Windsor | Ontario | N8W 1L9 | Canada | Details | |
| Local Institution - 0238 | Hefei | Anhui | 230001 | China | Details | |
| Local Institution - 0243 | Hefei | Anhui | 230022 | China | Details | |
| Local Institution | Beijing | Beijing | 100001 | China | Details | |
| Local Institution | Beijing | Beijing | 100142 | China | Details | |
| Local Institution - 0221 | Harbin | Heilongjiang | 155040 | China | Details | |
| Local Institution - 0244 | Wuhang | Hubei | 430030 | China | Details | |
| Local Institution - 0248 | Nantong | Jiangsu | 226361 | China | Details | |
| Local Institution - 0230 | Nanchang | Jiangxi | 330006 | China | Details | |
| Local Institution | Changchun | Jilin | 130021 | China | Details | |
| Local Institution - 0237 | Shenyang | Liaoning | 110046 | China | Details | |
| Local Institution - 0220 | Shanghai | Shanghai | 200030 | China | Details | |
| Local Institution - 0228 | Shanghai | Shanghai | 200030 | China | Details | |
| Local Institution - 0233 | Shanghai | Shanghai | 200032 | China | Details | |
| Local Institution - 0245 | Shanghai | Shanghai | 200433 | China | Details | |
| Local Institution - 0232 | Kunming | Yunnan | 650118 | China | Details | |
| Local Institution - 0239 | Hangzhou | Zhejiang | 310003 | China | Details | |
| Local Institution - 0227 | Hangzhou | Zhejiang | 310016 | China | Details | |
| Local Institution - 0246 | Wenzhou | Zhejiang | 325000 | China | Details | |
| Local Institution - 0247 | Changsha | 0 | China | Details | ||
| Local Institution - 0240 | Guangzhou | 510515 | China | Details | ||
| Local Institution | Monteria | Cordoba | Colombia | Details | ||
| Local Institution - 0078 | Bogota | 0 | Colombia | Details | ||
| Local Institution | Medellin | MEDELLIN | Colombia | Details | ||
| Local Institution - 0044 | Oulu | 90029 | Finland | Details | ||
| Local Institution - 0043 | Tampere | 33521 | Finland | Details | ||
| Local Institution - 0045 | Turku | FIN-20521 | Finland | Details | ||
| Local Institution - 0046 | Vaasa | 65130 | Finland | Details | ||
| Local Institution - 0149 | Strasbourg | Alsace | 67091 | France | Details | |
| Local Institution - 0208 | Avignon Cedes 9 | 84918 | France | Details | ||
| Local Institution - 0099 | Lyon Cedex 08 | 69373 | France | Details | ||
| Local Institution - 0098 | Marseille Cedex 20 | 13915 | France | Details | ||
| Local Institution - 0097 | Paris Cedex 20 | 75970 | France | Details | ||
| Local Institution - 0095 | Pierre Benite | 69495 | France | Details | ||
| Local Institution - 0100 | Rennes Cedex 9 | 35033 | France | Details | ||
| Local Institution - 0150 | Saint Herblain | 44805 | France | Details | ||
| Local Institution - 0096 | Toulouse | 31059 | France | Details | ||
| Local Institution - 0171 | Augsburg | 86156 | Germany | Details | ||
| Local Institution - 0170 | Bad Berka | 99437 | Germany | Details | ||
| Local Institution - 0168 | Berlin | 14165 | Germany | Details | ||
| Local Institution - 0164 | Bochum | 44791 | Germany | Details | ||
| Local Institution - 0166 | Gauting | 82131 | Germany | Details | ||
| Local Institution - 0165 | Grosshansdorf | 22927 | Germany | Details | ||
| Local Institution - 0169 | Immenhausen | 34376 | Germany | Details | ||
| Local Institution - 0167 | Tübingen | 72076 | Germany | Details | ||
| Local Institution - 0080 | N.Kifissia | 14564 | Greece | Details | ||
| Interbalkan European Medical Center | Thessaloniki | 57001 | Greece | Details | ||
| Local Institution - 0052 | Hong Kong | 0 | Hong Kong | Details | ||
| Local Institution - 0161 | Wilton | Cork | 0 | Ireland | Details | |
| Local Institution - 0175 | Dublin | 24 | Ireland | Details | ||
| Local Institution | Dublin | 4 | Ireland | Details | ||
| Local Institution - 0162 | Galway | ST4 6QG | Ireland | Details | ||
| Local Institution - 0214 | Limerick | 0 | Ireland | Details | ||
| Local Institution | Haifa | 31096 | Israel | Details | ||
| Local Institution - 0093 | Jerusalem | 91031 | Israel | Details | ||
| Local Institution | Petach Tikva | 49100 | Israel | Details | ||
| Local Institution - 0090 | Tel Aviv | 64239 | Israel | Details | ||
| Local Institution - 0089 | Zerifin | 70300 | Israel | Details | ||
| Local Institution - 0027 | Milan | Lombardia | 20141 | Italy | Details | |
| Local Institution - 0026 | Avellino | 83100 | Italy | Details | ||
| Local Institution - 0025 | Bologna | 40138 | Italy | Details | ||
| Local Institution - 0112 | Messina | 98158 | Italy | Details | ||
| Local Institution - 0082 | Perugia | 06132 | Italy | Details | ||
| Local Institution - 0139 | Kashiwa-shi | Chiba | 2778577 | Japan | Details | |
| Local Institution - 0142 | Matsuyama-shi | Ehime | 7910280 | Japan | Details | |
| Local Institution - 0146 | Fukuoka-shi | Fukuoka | 8128582 | Japan | Details | |
| Local Institution - 0200 | Kurume-shi | Fukuoka | 8300011 | Japan | Details | |
| Local Institution - 0198 | Gifu-shi | Gifu | 5008513 | Japan | Details | |
| Local Institution - 0143 | Sapporo-shi | Hokkaido | 0608648 | Japan | Details | |
| Local Institution - 0076 | Kobe-shi | Hyogo | 6500047 | Japan | Details | |
| Local Institution - 0138 | Kanazawa-shi | Ishikawa | 9208641 | Japan | Details | |
| Local Institution - 0072 | Yokohama-shi | Kanagawa | 2408555 | Japan | Details | |
| Local Institution - 0070 | Sendai-shi | Miyagi | 9800873 | Japan | Details | |
| Local Institution - 0069 | Sendai-shi | Miyagi | 9808574 | Japan | Details | |
| Local Institution - 0077 | Kurashiki-shi | Okayama | 7108602 | Japan | Details | |
| Local Institution | Hirakata-shi | Osaka | 5731191 | Japan | Details | |
| Local Institution - 0075 | Osaka-sayama-shi | Osaka | 5898511 | Japan | Details | |
| Local Institution - 0145 | Osaka-shi | Osaka | 5340021 | Japan | Details | |
| Local Institution - 0083 | Takatsuki-shi | Osaka | 5698686 | Japan | Details | |
| Local Institution - 0193 | Hidaka | Saitama | 350-1298 | Japan | Details | |
| Local Institution - 0141 | Bunkyo-ku | Tokyo | 113-8603 | Japan | Details | |
| Local Institution - 0071 | Chuo-ku | Tokyo | 1040045 | Japan | Details | |
| Local Institution - 0140 | Koto-ku | Tokyo | 1358550 | Japan | Details | |
| Local Institution - 0144 | Shinjuku-ku | Tokyo | 1600023 | Japan | Details | |
| Local Institution - 0216 | Wakayama | 641-8510 | Japan | Details | ||
| Local Institution - 0047 | Seongnam-si | Gyeonggi-do | 13620 | Korea, Republic of | Details | |
| Local Institution - 0024 | Suwon | Kyǒnggi-do | 16499 | Korea, Republic of | Details | |
| Local Institution - 0021 | Gangnam-gu | 06351 | Korea, Republic of | Details | ||
| Local Institution - 0022 | Seoul | 03722 | Korea, Republic of | Details | ||
| Local Institution - 0154 | Seoul | 05505 | Korea, Republic of | Details | ||
| Local Institution - 0019 | Mexico | Distrito Federal | 14050 | Mexico | Details | |
| Local Institution - 0020 | Leon de los Aldama | Guanajuato | 37000 | Mexico | Details | |
| Local Institution - 0028 | Monterrey | Nuevo Leon | 64000 | Mexico | Details | |
| Local Institution - 0135 | Queretaro | 76090 | Mexico | Details | ||
| Local Institution - 0158 | 's-Hertogenbosch | 5223 GZ | Netherlands | Details | ||
| Local Institution | Eindhoven | 5623 EJ | Netherlands | Details | ||
| Local Institution - 0159 | Rotterdam | 3000 CA | Netherlands | Details | ||
| Local Institution | Miraflores | Lima | 18 | Peru | Details | |
| Local Institution | Lima | 27 | Peru | Details | ||
| Local Institution | Lima | 34 | Peru | Details | ||
| Local Institution - 0041 | Gdansk | 80-19 | Poland | Details | ||
| Local Institution - 0054 | Gdynia | 81-519 | Poland | Details | ||
| Local Institution - 0053 | Olsztyn | 10-357 | Poland | Details | ||
| Local Institution - 0187 | Warszawa | 02-781 | Poland | Details | ||
| Local Institution - 0199 | Bucharest | 010991 | Romania | Details | ||
| Local Institution - 0186 | Bucharest | 020122 | Romania | Details | ||
| Local Institution - 0182 | Craiova | 200347 | Romania | Details | ||
| Local Institution - 0178 | Lasi | 700106 | Romania | Details | ||
| Local Institution - 0212 | Romania | 400015 | Romania | Details | ||
| Local Institution - 0181 | Timisoara, Timis | 300239 | Romania | Details | ||
| Local Institution - 0148 | Moscow | 105229 | Russian Federation | Details | ||
| Local Institution - 0217 | Moscow | 115478 | Russian Federation | Details | ||
| Local Institution - 0209 | Moscow | 121309 | Russian Federation | Details | ||
| Local Institution - 0157 | St Petersburg | 197758 | Russian Federation | Details | ||
| Local Institution - 0115 | St Petersburg | 198255 | Russian Federation | Details | ||
| Local Institution - 0116 | St. Petersburg | 194291 | Russian Federation | Details | ||
| Local Institution - 0050 | Singapore | 169610 | Singapore | Details | ||
| Local Institution - 0087 | Sandton | Gauteng | 2199 | South Africa | Details | |
| Local Institution - 0084 | Cape Town | Western Cape | 7570 | South Africa | Details | |
| Local Institution - 0085 | Cape Town | Western CAPE | 7700 | South Africa | Details | |
| Local Institution - 0086 | George | Western CAPE | 6530 | South Africa | Details | |
| Local Institution - 0132 | Barcelona | 08035 | Spain | Details | ||
| Local Institution | Barcelona | 08036 | Spain | Details | ||
| Local Institution | Madrid | 28040 | Spain | Details | ||
| Local Institution | Malaga | 29011 | Spain | Details | ||
| Local Institution | Sevilla | 41013 | Spain | Details | ||
| Local Institution - 0124 | Lund | 221 85 | Sweden | Details | ||
| Local Institution - 0185 | Uppsala | 751 85 | Sweden | Details | ||
| Local Institution - 0179 | Aarau | 5001 | Switzerland | Details | ||
| Local Institution - 0180 | Geneve | 1205 | Switzerland | Details | ||
| Local Institution - 0191 | St. Gallen | 9007 | Switzerland | Details | ||
| Local Institution - 0049 | Tainan | TNN | 704 | Taiwan | Details | |
| Local Institution - 0048 | Taoyuan | 333 | Taiwan | Details | ||
| Local Institution - 0153 | Truro | Cornwall | TR1 3LJ | United Kingdom | Details | |
| Local Institution - 0118 | London | Greater London | NW1 2PG | United Kingdom | Details | |
| Local Institution - 0201 | London | Greater London | SW3 6JJ | United Kingdom | Details | |
| Local Institution - 0121 | Wirral | Lancashire | CH63 4JY | United Kingdom | Details | |
| Local Institution - 0152 | Oxford | Oxfordshire | OX3 7LJ | United Kingdom | Details | |
| Local Institution - 0151 | Sutton | Surrey | SM2 5PT | United Kingdom | Details | |
| Local Institution - 0192 | Sheffield | S10 2SJ | United Kingdom | Details |