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NCT ID NCT03056755
Title Study Assessing the Efficacy and Safety of Alpelisib Plus Fulvestrant or Letrozole, Based on Prior Endocrine Therapy, in Patients With PIK3CA Mutation With Advanced Breast Cancer Who Have Progressed on or After Prior Treatments (BYLieve)
Recruitment Active, not recruiting
Gender both
Phase Phase II
Variant Requirements Yes
Sponsors Novartis Pharmaceuticals
Indications

Her2-receptor negative breast cancer

Therapies

Alpelisib + Fulvestrant

Alpelisib + Letrozole

Age Groups: adult | senior
Covered Countries USA | CAN

Facility Status City State Zip Country Details
Banner MD Anderson Cancer Center Gilbert Arizona 85234 United States Details
Mayo Clinic (Arizona) Phoenix Arizona 85054 United States Details
Kaiser Permanente Medical Group Kaiser Permanente-Moanalua M.C Anaheim California 92807 United States Details
Beverly Hills Cancer Center Beverly Hills California 90211 United States Details
University of Calif Irvine Medical Center Orange California 92868 United States Details
Kaiser Permanente Southern California San Diego California 92120 United States Details
University of California, San Francisco San Francisco California 94115 United States Details
Yale University Yale Cancer Center New Haven Connecticut 06511 United States Details
Advent Health Cancer Institute Orlando Florida 32804 United States Details
University of Kansas Cancer Center Kansas City Kansas 66205 United States Details
University of Louisville Hospital/James Brown Cancer Ctr. SC Louisville Kentucky 40202 United States Details
Mercy Medical Center Baltimore Maryland 21202 United States Details
Greater Baltimore Medical Center Cancer Center Baltimore Maryland 21204-6831 United States Details
Massachusetts General Hospital Neuroendocrine Unit Boston Massachusetts 02114 United States Details
Lahey Clinic Burlington Massachusetts 01805 United States Details
Josephine Ford Cancer Institute Detroit Michigan 48202 United States Details
St Vincent Frontier Cancer Center Billings Montana 59102 United States Details
New Mexico Cancer Care Alliance Albuquerque New Mexico 87106 United States Details
Memorial Sloane Kettering Cancer Center New York New York 10065 United States Details
University Hospitals of Cleveland Seidman Cancer Center Cleveland Ohio 44106 United States Details
Texas Oncology Charles A. Sammons Cancer Ctr Dallas Texas 75246 United States Details
Cancer Care Centers of South Texas HOAST CCC of So. TX- San Antonio(2) San Antonio Texas 78229 United States Details
UT Health San Antonio San Antonio Texas 78229 United States Details
Virginia Oncology Associates SC Norfolk Virginia 23502 United States Details
Northwest Medical Specialists Tacoma Washington 98405 United States Details
Novartis Investigative Site Caba Buenos Aires C1118AAT Argentina Details
Novartis Investigative Site Caba Buenos Aires C1125ABD Argentina Details
Novartis Investigative Site Caba Buenos Aires C1426ANZ Argentina Details
Novartis Investigative Site Rosario Santa Fe S2000DSV Argentina Details
Novartis Investigative Site Rosario Sante Fe S200KZE Argentina Details
Novartis Investigative Site La Rioja 5300 Argentina Details
Novartis Investigative Site Leuven 3000 Belgium Details
Novartis Investigative Site Liege 4000 Belgium Details
Novartis Investigative Site Vancouver British Columbia V5Z 4E6 Canada Details
Novartis Investigative Site Halifax Nova Scotia B3H 2Y9 Canada Details
Novartis Investigative Site Kitchener Ontario N2G 1G3 Canada Details
Novartis Investigative Site Toronto Ontario M5B 1N9 Canada Details
Novartis Investigative Site Temuco Araucania 4810469 Chile Details
Novartis Investigative Site Santiago 7500921 Chile Details
Novartis Investigative Site Santiago 8420383 Chile Details
Novartis Investigative Site Odense C DK 5000 Denmark Details
Novartis Investigative Site Vejle 7100 Denmark Details
Novartis Investigative Site Nice Cedex 2 Alpes Maritimes 06189 France Details
Novartis Investigative Site Saint-Cloud Hauts De Seine 92210 France Details
Novartis Investigative Site Bordeaux 33076 France Details
Novartis Investigative Site Caen Cedex 14021 France Details
Novartis Investigative Site Lille Cedex 59020 France Details
Novartis Investigative Site Lyon Cedex 69373 France Details
Novartis Investigative Site Montpellier Cedex 5 34298 France Details
Novartis Investigative Site Saint Herblain cedex 44805 France Details
Novartis Investigative Site Strasbourg Cedex F 67098 France Details
Novartis Investigative Site Toulouse Cedex 9 31059 France Details
Novartis Investigative Site Augsburg 86150 Germany Details
Novartis Investigative Site Berlin 14169 Germany Details
Novartis Investigative Site Dresden 01307 Germany Details
Novartis Investigative Site Erlangen 91054 Germany Details
Novartis Investigative Site Essen 45136 Germany Details
Novartis Investigative Site Heidelberg 69120 Germany Details
Novartis Investigative Site Ulm 89081 Germany Details
Novartis Investigative Site Delhi 110 085 India Details
Novartis Investigative Site Petach Tikva 4910002 Israel Details
Novartis Investigative Site Ramat Gan 52621 Israel Details
Novartis Investigative Site Rehovot 7610001 Israel Details
Novartis Investigative Site Tel Aviv 6423906 Israel Details
Novartis Investigative Site Ancona AN 60126 Italy Details
Novartis Investigative Site Bergamo BG 24127 Italy Details
Novartis Investigative Site Genova GE 16132 Italy Details
Novartis Investigative Site Milano MI 20133 Italy Details
Novartis Investigative Site Milano MI 20141 Italy Details
Novartis Investigative Site Roma RM 00168 Italy Details
Novartis Investigative Site Bologna 40138 Italy Details
Novartis Investigative Site Napoli 80131 Italy Details
Novartis Investigative Site Osaka-city Osaka 540-0006 Japan Details
Novartis Investigative Site Seoul 03080 Korea, Republic of Details
Novartis Investigative Site Seoul 06351 Korea, Republic of Details
Novartis Investigative Site Mexico D F Distrito Federal 06760 Mexico Details
Novartis Investigative Site Jalisco 45640 Mexico Details
Novartis Investigative Site Maastricht AZ 5800 Netherlands Details
Novartis Investigative Site Singapore 169610 Singapore Details
Novartis Investigative Site Singapore 217562 Singapore Details
Novartis Investigative Site Sevilla Andalucia 41013 Spain Details
Novartis Investigative Site Salamanca Castilla Y Leon 37007 Spain Details
Novartis Investigative Site Barcelona Catalunya 08035 Spain Details
Novartis Investigative Site Barcelona Catalunya 08036 Spain Details
Novartis Investigative Site Hospitalet de LLobregat Catalunya 08907 Spain Details
Novartis Investigative Site Castellon Comunidad Valenciana 12002 Spain Details
Novartis Investigative Site Madrid 28041 Spain Details
Novartis Investigative Site Tainan 70403 Taiwan Details
Novartis Investigative Site Taipei 10002 Taiwan Details
Novartis Investigative Site Taipei Taiwan Details
Novartis Investigative Site Sutton Surrey SM2 5PT United Kingdom Details
Novartis Investigative Site Edinburgh EH4 2XU United Kingdom Details
Novartis Investigative Site Leicester LE1 5WW United Kingdom Details
Novartis Investigative Site London SW3 6JJ United Kingdom Details
Novartis Investigative Site Nottingham NG5 1PB United Kingdom Details
*Shaded cells indicate that there was no data available from clincialtrials.gov for the field