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NCT ID NCT03498521
Title A Phase II Randomized Study Comparing the Efficacy and Safety of Targeted Therapy or Cancer Immunotherapy Versus Platinum-Based Chemotherapy in Patients With Cancer of Unknown Primary Site (CUPISCO)
Recruitment Recruiting
Gender both
Phase Phase II
Variant Requirements No
Sponsors Hoffmann-La Roche
Indications

Advanced Solid Tumor

Therapies

Atezolizumab + Paclitaxel

Carboplatin

Carboplatin + Paclitaxel

Olaparib

Vismodegib

Alectinib

Bevacizumab + Erlotinib

Cisplatin + Gemcitabine

Cobimetinib + Vemurafenib

Ipatasertib + Paclitaxel

Cisplatin + Paclitaxel

Gemcitabine

Atezolizumab

Entrectinib

Pertuzumab + Trastuzumab

Paclitaxel + Pertuzumab + Trastuzumab

Ipatasertib

Carboplatin + Gemcitabine

Age Groups: adult | senior
Covered Countries ITA | FRA | ESP | DEU | AUT

Facility Status City State Zip Country Details
Blacktown Hospital Recruiting Blacktown New South Wales 2148 Australia Details
Northern Cancer Institute Recruiting St Leonards New South Wales 2065 Australia Details
Icon Cancer Foundation Active, not recruiting South Brisbane Queensland 4101 Australia Details
Flinders Medical Centre Completed Bedford Park South Australia 5042 Australia Details
Peter MacCallum Cancer Center Active, not recruiting East Melbourne Victoria 3002 Australia Details
LKH-UNIV. KLINIKUM GRAZ; Klinische Abteilung für Onkologie Recruiting Graz 8036 Austria Details
Lkh Salzburg - Univ. Klinikum Salzburg; Iii. Medizinische Abt. Recruiting Salzburg 5020 Austria Details
Medizinische Universität Wien; Univ.Klinik für Innere Medizin I - Chemotherapie & Infektionskrankhei Recruiting Wien 1090 Austria Details
Hospital Sao Rafael - HSR Recruiting Salvador BA 41253-190 Brazil Details
Instituto Nacional de Cancer - INCa; Oncologia Recruiting Rio de Janeiro RJ 20560-120 Brazil Details
Hospital Nossa Senhora da Conceicao Active, not recruiting Porto Alegre RS 91350-200 Brazil Details
Hospital de Cancer de Barretos Recruiting Barretos SP 14784-400 Brazil Details
Instituto do Cancer do Estado de Sao Paulo - ICESP Recruiting Sao Paulo SP 01246-000 Brazil Details
Multiprofile Hospital for Active Treatment Uni Hospital; Department of medicinal oncology Recruiting Panagyurishte 4500 Bulgaria Details
Complex Oncology Center (COC)-Plovidiv Withdrawn Plovdiv 4000 Bulgaria Details
MHAT Nadezhda Recruiting Sofia 1330 Bulgaria Details
MBAL Serdika EOOD Recruiting Sofia 1632 Bulgaria Details
Bradford Hill Centro de Investigaciones Clinicas; Bradford Hill Centro de Investigaciones Clinicas Recruiting Recoleta 8420383 Chile Details
James Lind Centro de Investigación Del Cáncer Active, not recruiting Temuco 4800827 Chile Details
Clinica del Country Active, not recruiting Bogota 11001 Colombia Details
Inst. Nacional de Cancerologia; Clinica de Seno Recruiting Bogota 111511 Colombia Details
Clínica Imbanaco; Oncology Recruiting Cali Colombia Details
Fundacion Clinica Valle del Lili; Unidad de Investigaciones Clinicas Withdrawn Cali Colombia Details
Oncomedica S.A. Active, not recruiting Monteria 230002 Colombia Details
Clinical Hospital Centre Zagreb Active, not recruiting Zagreb 10000 Croatia Details
Bank of Cyprus Oncology Center Withdrawn Nicosia 2006 Cyprus Details
Masarykuv onkologicky ustav Recruiting Brno 656 53 Czechia Details
Fakultni nemocnice Olomouc; Onkologicka klinika Recruiting Olomouc 779 00 Czechia Details
Fakultni Poliklinika Vseobecne Fakultni Niemocnice; Onkologicka Klinika Active, not recruiting Praha 2 128 08 Czechia Details
Aarhus Universitetshospital, Afdeling for Eksperimentel Klinisk Onkologi Recruiting Aarhus N 8200 Denmark Details
Rigshospitalet; Onkologisk Klinik Recruiting København Ø 2100 Denmark Details
North Estonia Medical Centre, Oncology and hematology Clinic; Department of Chemotherapy Recruiting Tallinn 13419 Estonia Details
Helsinki University Central Hospital; Dept of Oncology Recruiting Helsinki 00250 Finland Details
Tampere University Hospital; Dept of Oncology Recruiting Tampere 33520 Finland Details
Ico - Paul Papin Recruiting Angers 49000 France Details
CHRU Besançon Recruiting Besançon 25030 France Details
Institut Bergonie; Oncologie Recruiting Bordeaux 33076 France Details
CRLCC-Francois Baclesse; Oncologie Médicale Recruiting Caen 14076 France Details
Centre Jean Perrin Centre Regional de Lutte Contre Le Cancer D auvergne Recruiting Clermont-ferrand 63003 France Details
Centre Leon Berard Recruiting Lyon 69008 France Details
Institut Paoli-Calmettes; Oncologie Medicale 1 Recruiting Marseille Cedex 09 13273 France Details
Institut régional du Cancer Montpellier Recruiting Montpellier 34298 France Details
Centre Antoine Lacassagne Recruiting Nice 06189 France Details
Institut Curie; Oncologie Medicale Recruiting Paris 75231 France Details
CHU Lyon - Centre Hospitalier Lyon Sud Recruiting Pierre-Benite (Lyon) 69495 France Details
Centre Eugene Marquis; Service d'oncologie Recruiting Rennes 35042 France Details
CHU Strasbourg - Hôpital Hautepierre Recruiting Strasbourg 67098 France Details
Hopital Foch; Oncologie Recruiting Suresnes 92151 France Details
Institut Gustave Roussy Recruiting Villejuif 94805 France Details
Universitätsklinikum Augsburg; II. Med. Klinik Recruiting Augsburg 86156 Germany Details
Charité-Universitätsm. Berlin; Med. Klinik mit Schwerpunkt Hämatologie, Onkologie und Tumorimmunolo. Recruiting Berlin 10117 Germany Details
Onkologisches Zentrum - Onkologie Dachau Recruiting Dachau 85221 Germany Details
Universitätsklinikum "Carl Gustav Carus" der Technischen Universität Dresden Active, not recruiting Dresden 01307 Germany Details
Universitätsklinikum Düsseldorf; Klinik für Hämatologie, Onkologie und Klinische Immunologie Completed Düsseldorf 40225 Germany Details
Kliniken Essen-Mitte, Evang. Huyssens-Stiftung, Klinik für Internistische Onkologie / Haematologie Active, not recruiting Essen 45136 Germany Details
Universitätsklinikum Frankfurt, UCT; Universitäres Centrum für Tumorerkrankungen Recruiting Frankfurt 60590 Germany Details
Universitätsklinikum Hamburg-Eppendorf, Onkologisches Zentrum, Studienzentrale der II. Med. Klinik Withdrawn Hamburg 20246 Germany Details
Praxis für Onkologie Recruiting Hannover 30449 Germany Details
Universitätsklinikum Heidelberg;Innere Medizin V, Hämatologie/Onkologie Recruiting Heidelberg 69120 Germany Details
SLK-Kliniken Heilbronn GmbH; Klinik für Innere Medizin III; Schwerpunkt Häma./Onko./Palliativm. Recruiting Heilbronn 74078 Germany Details
Universitätsklinikum Jena, Klinik für Innere Medizin II; Hämatologie und Internistische Onkologie Recruiting Jena 07747 Germany Details
Uni. der Johannes Gutenberg-Universitaet Mainz; III. Medizinische Klinik und Poliklinik Completed Mainz 55131 Germany Details
Klinikum Mannheim III. Medizinische Klinik Recruiting Mannheim 68167 Germany Details
Klinikum der LMU München, Campus Großhadern, Krebszentrum München; Comprehensive Cancer Center LMU Recruiting München 81377 Germany Details
Universitätsklinikum Münster, Medizinische Klinik A, Translationale Onkologie Recruiting Münster 48149 Germany Details
ohO - ostholstein ONKOLOGIE; Dres.Gerdt Hübner/Clemens Engels (Oldenburg)/Yael Bonnin-Gruber (Eutin) Active, not recruiting Oldenburg / Holstein 23758 Germany Details
Anticancer Hospital Ag Savas; 1St Dept of Internal Medicine Recruiting Athens 115 22 Greece Details
IASO General Hospital of Athens Recruiting Athens 155 62 Greece Details
Univ General Hosp Heraklion; Medical Oncology Recruiting Heraklion 711 10 Greece Details
Uni Hospital of Ioannina; Oncology Dept. Recruiting Ioannina 455 00 Greece Details
Theagenio Anticancer Hospital; 3Rd Oncology Clinic Active, not recruiting Thessaloniki 546 39 Greece Details
Semmelweis Egyetem; Onkológiai Központ Withdrawn Budapest 1083 Hungary Details
Orszagos Onkologiai Intezet; B Belgyogyaszati Osztaly Active, not recruiting Budapest 1122 Hungary Details
Uzsoki Utcai Korhaz; Onkoradiológiai Osztály Active, not recruiting Budapest 1145 Hungary Details
Debreceni Egyetem Klinikai Kozpont ; Department of Oncology Withdrawn Debrecen 4032 Hungary Details
Bacs-Kiskun Megyei Korhaz, SZTE AOK Oktato Korhaza, Onkoradiologiai Kozpont Recruiting Kecskemet 6000 Hungary Details
Szegedi Tudomanyegyetem, AOK, Szent-Gyorgyi Albert Klinikai Kozpont, Onkoterapias Klinika Recruiting Szeged 6720 Hungary Details
St Vincent'S Uni Hospital; Medical Oncology Recruiting Dublin 4 Ireland Details
Waterford Regional Hospital; Department Of Medical Oncology Active, not recruiting Waterford X91 ER8E Ireland Details
Rabin MC; Davidof Center - Oncology Institute Recruiting Petach Tikva 4941492 Israel Details
Chaim Sheba medical center, Oncology division Recruiting Ramat Gan 5262000 Israel Details
Tel Aviv Sourasky Medical Ctr; Oncology Recruiting Tel Aviv 6423906 Israel Details
U. O. Oncologia Medica, Ospedale Santa Chiara Recruiting Pisa Basilicata 56100 Italy Details
Policlinico Univ. - A.O. Mater Domini; U.O. Di Oncoematologia Recruiting Catanzaro Calabria 88100 Italy Details
Istituto Nazionale Tumori Fondazione G. Pascale Recruiting Napoli Campania 80131 Italy Details
Arcispedale Santa Maria Nuova; Oncologia Recruiting Reggio Emilia Emilia-Romagna 42100 Italy Details
Asst Papa Giovanni XXIII; Oncologia Medica Recruiting Bergamo Lombardia 24127 Italy Details
Irccs Ospedale San Raffaele;Oncologia Medica Withdrawn Milano Lombardia 20132 Italy Details
Azienda Socio Sanitaria Territoriale Niguarda (Ospedale Niguarda Ca' Granda); Oncologico -Onc.Falck Recruiting Milano Lombardia 20162 Italy Details
A.O. UNIVERSITARIA S. LUIGI GONZAGA; Oncologia Medica Recruiting Orbassano Piemonte 10043 Italy Details
Azienda Ospedaliera Di Perugia Ospedale s. Maria Della Misericordia; Oncologia Medica Recruiting Sant'Andrea Delle Fratte (PG) Umbria 06132 Italy Details
IRCCS Istituto Oncologico Veneto (IOV); Oncologia Medica Prima Recruiting Padova Veneto 35128 Italy Details
Aichi Cancer Center Recruiting Aichi 464-8681 Japan Details
National Cancer Center Hospital East Recruiting Chiba 277-8577 Japan Details
National Hospital Organization Shikoku Cancer Center Recruiting Ehime 791-0280 Japan Details
National Hospital Organization Kyushu Cancer Center Recruiting Fukuoka 811-1395 Japan Details
The Cancer Institute Hospital of JFCR Recruiting Tokyo 135-8550 Japan Details
Kazakh Scientific Research Institution Of Oncology and Radiology; Chemotherapy department Withdrawn Almaty 050022 Kazakhstan Details
Multidisciplinary medical center; Chemotherapy department Withdrawn Astana 010000 Kazakhstan Details
Seoul National University Hospital Recruiting Seoul 03080 Korea, Republic of Details
Asan Medical Center Recruiting Seoul 05505 Korea, Republic of Details
Samsung Medical Center Recruiting Seoul 06351 Korea, Republic of Details
Severance Hospital, Yonsei University Health System; Oncology Recruiting Seoul 120-752 Korea, Republic of Details
Riga East Clinical University Hospital Latvian Oncology Centre Recruiting Riga LV-1079 Latvia Details
Health Pharma Professional Research Recruiting Cdmx Mexico CITY (federal District) 03100 Mexico Details
Instituto Nacional de Cancerologia Recruiting Mexico City 14080 Mexico Details
AVIX Investigación Clínica S.C Recruiting Monterrey 64710 Mexico Details
Centro Oncologico Estatal ISSEMYM Withdrawn Toluca 50180 Mexico Details
Erasmus MC Active, not recruiting Rotterdam 3015 GD Netherlands Details
Universitair Medisch Centrum Utrecht Completed Utrecht 3584 CX Netherlands Details
Ziekenhuis VieCuri Medisch Centrum Recruiting Venlo 5912 BL Netherlands Details
Sørlandet Sykehus Kristiansand Completed Kristiansand 4604 Norway Details
Akershus universitetssykehus HF Completed Lørenskog 1478 Norway Details
Oslo universitetssykehus HF, Ullevål, Kreftsenteret Completed Oslo 0450 Norway Details
Helse Stavanger HF, Stavanger Universitetssjukehus; Klinikk for Blod og kreftsykdommer Withdrawn Stavanger 4011 Norway Details
Hospital Nacional Cayetano Heredia; Hematology - Oncology Recruiting Lima 31 Peru Details
Oncosalud Sac; Oncología Recruiting Lima 41 Peru Details
Instituto Nacional de Enfermedades Neoplasicas Recruiting Lima Lima 34 Peru Details
Szpital Uniwersytecki w Krakowie, Oddział Kliniczny Kliniki Onkologii Completed Kraków 30-688 Poland Details
Narodowy Instytut Onkologii im. M. Sklodowskiej-Curie; Oddzial Badan Wczesnych Faz Completed Warszawa 02-781 Poland Details
IPO do Porto; Servico de Oncologia Medica Recruiting Porto 4200-072 Portugal Details
Institutul Oncologic Prof. Dr. Ion Chiricuta Cluj Napoca; Oncologie Medicala Active, not recruiting Cluj Napoca 400015 Romania Details
Centrul de Oncologie Sfantul Nectarie Active, not recruiting Craiova 200347 Romania Details
Institutul Regional de Oncologie Iasi; Clinica de Hematologie Recruiting Iasi 700483 Romania Details
Oncocenter Timisoara Recruiting Timişoara 300166 Romania Details
Hospital Sant Joan Despi- Moises Broggi; Servicio de Oncologia Active, not recruiting Sant Joan Despí Barcelona 08970 Spain Details
Hospital Quiron de Madrid; Servicio de Oncologia Withdrawn Pozuelo de Alarcon Madrid 28223 Spain Details
Complejo Hospitalario de Navarra; Servicio de Oncologia Recruiting Pamplona Navarra 31008 Spain Details
Complexo Hospitalario de Vigo. Hospital Álvaro Cunqueiro; Servicio de Oncología Recruiting Vigo Pontevedra 36312 Spain Details
Hospital Clínic i Provincial; Servicio de Oncología Recruiting Barcelona 08036 Spain Details
Institut Catala d Oncologia Hospital Duran i Reynals Active, not recruiting Barcelona 08908 Spain Details
Hospital Ramon y Cajal; Servicio de Oncologia Recruiting Madrid 28034 Spain Details
Hospital Clinico San Carlos; Servicio de Oncologia Recruiting Madrid 28040 Spain Details
Hospital Universitario 12 de Octubre; Servicio de Oncologia Active, not recruiting Madrid 28041 Spain Details
Hospital Clinico Universitario Virgen de la Victoria; Servicio de Oncologia Recruiting Malaga 29010 Spain Details
Hospital Universitario Virgen Macarena; Servicio de Oncologia Recruiting Sevilla 41009 Spain Details
Hospital Universitari i Politecnic La Fe; Oncologia Recruiting Valencia 46026 Spain Details
Hospital Universitario Miguel Servet; Servicio Oncologia Recruiting Zaragoza 50009 Spain Details
Universitaetsspital Basel; Onkologie Recruiting Basel 4031 Switzerland Details
Kantonsspital Graubünden Medizin Onkologie; Onkologie und Hämatologie Active, not recruiting Chur 7000 Switzerland Details
UniversitätsSpital Zürich; Zentrum für Hämatologie und Onkologie, Klinik für Onkologie Recruiting Zürich 8091 Switzerland Details
Ramathibodi Hospital; Medicine/Oncology; Clinical Research Center Recruiting Bangkok 10400 Thailand Details
Faculty of Med. Siriraj Hosp.; Med.-Div. of Med. Oncology Active, not recruiting Bangkok 10700 Thailand Details
Baskent University Adana Dr. Turgut Noyan Practice and Research Hospital; Medical Oncology Active, not recruiting Adana 01230 Turkey Details
Ankara University Medical Faculty; Medikal Onkoloji Recruiting Ankara 06100 Turkey Details
Ankara Oncology Hospital; Oncology Active, not recruiting Ankara 06200 Turkey Details
Akdeniz University Medical Faculty; Medical Oncology Department Recruiting Antalya 07070 Turkey Details
Trakya Universitesi Tip Fakultesi, Medikal Onkoloji Bilim Dali, Balkan Yerleskesi Recruiting Edirne 22030 Turkey Details
Istanbul University Cerrahpaşa-Cerrahpaşa Medical Faculty; Medikal Onkoloji Departmani Active, not recruiting Istanbul 34098 Turkey Details
İzmir Medical Park; Onkoloji Active, not recruiting Izmır 35575 Turkey Details
Acıbadem Maslak Hastanesi Büyükdere Withdrawn Sarıyer/İstanbul 34457 Turkey Details
Hacettepe Uni Medical Faculty Hospital; Oncology Dept Active, not recruiting Sihhiye/Ankara 06230 Turkey Details
Royal United Hospital; Oncology Department Recruiting Bath BA1 3NG United Kingdom Details
Velindre Cancer Centre Recruiting Cardiff CF14 2TL United Kingdom Details
Western General Hospital; Edinburgh Cancer Center Recruiting Edinburgh EH4 2XU United Kingdom Details
Beatson West of Scotland Cancer Centre Recruiting Glasgow G12 0YN United Kingdom Details
University College London Hospitals NHS Foundation Trust - University College Hospital Recruiting London NW1 2PG United Kingdom Details
Hammersmith Hospital; Garry Weston Centre Recruiting London W12 0HS United Kingdom Details
Christie Hospital NHS Trust Recruiting Manchester M20 4BX United Kingdom Details
Freeman Hospital Recruiting Newcastle upon Tyne NE7 7DN United Kingdom Details
Southampton General Hospital Recruiting Southampton SO16 6YD United Kingdom Details
Torbay Hospital; Oncology Department Recruiting Torquay TQ27AA United Kingdom Details
*Shaded cells indicate that there was no data available from clincialtrials.gov for the field