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| NCT ID | NCT03515837 |
| Title | Study of Pemetrexed + Platinum Chemotherapy With or Without Pembrolizumab (MK-3475) in Adults With Tyrosine Kinase Inhibitor- (TKI)-Resistant Epidermal Growth Factor Receptor- (EGFR)-Mutated Metastatic Non-squamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-789/KEYNOTE-789) |
| Recruitment | Completed |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Merck Sharp & Dohme Corp. |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | ITA | GBR | FRA | ESP | DEU | CAN | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Cedars-Sinai Medical Center ( Site 0070) | Los Angeles | California | 90048 | United States | Details | |
| Pacific Cancer Care ( Site 0058) | Monterey | California | 93940 | United States | Details | |
| UC Irvine Medical Center/Chao Family Comprehensive Cancer Center ( Site 0092) | Orange | California | 92868 | United States | Details | |
| St. Joseph Heritage Healthcare ( Site 0003) | Santa Rosa | California | 95403 | United States | Details | |
| North Shore University Health System ( Site 0030) | Evanston | Illinois | 60201 | United States | Details | |
| Siouxland Regioinal Cancer Center dba June E. Nylen Cancer Center ( Site 0065) | Sioux City | Iowa | 51101 | United States | Details | |
| Southdale Cancer Care, University of Minnesota Medical Center- Edina ( Site 0048) | Edina | Minnesota | 55435 | United States | Details | |
| Saint Lukes Hospital of Kansas City ( Site 0060) | Kansas City | Missouri | 64111 | United States | Details | |
| New York Oncology Hematology P.C ( Site 8000) | Albany | New York | 12208 | United States | Details | |
| Monter Cancer Center ( Site 0054) | Lake Success | New York | 11042 | United States | Details | |
| Memorial Sloan Kettering Cancer Center-Rockerfeller Patient Pavilion ( Site 0049) | New York | New York | 10022 | United States | Details | |
| White Plains Hospital Center for Cancer Care ( Site 0014) | White Plains | New York | 10601 | United States | Details | |
| Providence Portland Medical Center ( Site 0097) | Portland | Oregon | 97213 | United States | Details | |
| Kaiser Permanente Northwest ( Site 0037) | Portland | Oregon | 97227 | United States | Details | |
| Parkland Health & Hospital System ( Site 2102) | Dallas | Texas | 75235 | United States | Details | |
| University of Texas Southwestern Medical Center at Dallas ( Site 0035) | Dallas | Texas | 75390 | United States | Details | |
| Utah Cancer Specialists ( Site 0001) | Salt Lake City | Utah | 84106 | United States | Details | |
| Emily Couric Clinical Cancer Center ( Site 0020) | Charlottesville | Virginia | 22903 | United States | Details | |
| Froedtert Hospital & the Medical College of Wisconsin ( Site 0041) | Milwaukee | Wisconsin | 53226 | United States | Details | |
| Chris OBrien Lifehouse ( Site 0200) | Camperdown | New South Wales | 2050 | Australia | Details | |
| Westmead Hospital ( Site 0201) | Westmead | New South Wales | 2145 | Australia | Details | |
| Eastern Health ( Site 0202) | Box Hill | Victoria | 3128 | Australia | Details | |
| Austin Health ( Site 0203) | Heidelberg | Victoria | 3084 | Australia | Details | |
| Liga Norte Riograndense Contra o Cancer ( Site 1909) | Natal | Rio Grande Do Norte | 59075-740 | Brazil | Details | |
| Hospital de Caridade de Ijui ( Site 1907) | Ijui | Rio Grande Do Sul | 98700-000 | Brazil | Details | |
| Hospital Bruno Born ( Site 1913) | Lajeado | Rio Grande Do Sul | 95900-010 | Brazil | Details | |
| Hospital de Clinicas de Porto Alegre ( Site 1905) | Porto Alegre | Rio Grande Do Sul | 90035-903 | Brazil | Details | |
| Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da Pucrs ( Site 1904) | Porto Alegre | Rio Grande Do Sul | 90610-000 | Brazil | Details | |
| Fundacao Pio XII - Hospital de Cancer de Barretos ( Site 1911) | Barretos | Sao Paulo | 14784-400 | Brazil | Details | |
| Hosp. Clinicas da Fac. de Medicina de Ribeirao Preto - USP ( Site 1912) | Ribeirao Preto | Sao Paulo | 14048-900 | Brazil | Details | |
| Instituto do Cancer do Estado de Sao Paulo - ICESP ( Site 1903) | Sao Paulo | 01246-000 | Brazil | Details | ||
| William Osler Health System ( Site 0100) | Brampton | Ontario | L6R 3J7 | Canada | Details | |
| Sunnybrook Health Sciences, Odette Cancer Centre ( Site 0102) | Toronto | Ontario | M4N 3M5 | Canada | Details | |
| Princess Margaret Cancer Centre ( Site 0104) | Toronto | Ontario | M5G 2M9 | Canada | Details | |
| Jewish General Hospital ( Site 0105) | Montreal | Quebec | H3T 1E2 | Canada | Details | |
| The First Affiliated Hospital of Anhui Medical University ( Site 0721) | Hefei | Anhui | 230088 | China | Details | |
| Cancer Hospital Chinese Academy of Medical Sciences ( Site 0717) | Beijing | Beijing | 100021 | China | Details | |
| Peking Union Medical College Hospital ( Site 0703) | Beijing | Beijing | 100032 | China | Details | |
| Beijing Cancer Hospital ( Site 0718) | Beijing | Beijing | 100036 | China | Details | |
| Southwest Hospital, The Third Military Medical University ( Site 0725) | Chongqing | Chongqing | 400038 | China | Details | |
| Fujian Cancer Hospital ( Site 0723) | Fuzhou | Fujian | 350014 | China | Details | |
| The Affiliated Tumour Hospital of Harbin Medical University ( Site 0706) | Harbin | Heilongjiang | 150081 | China | Details | |
| Henan Cancer Hospital ( Site 0711) | Zhengzhou | Henan | 450008 | China | Details | |
| Xiangya Hospital of Central South University ( Site 0710) | Changsha | Hunan | 410008 | China | Details | |
| Hunan Cancer Hospital ( Site 0722) | Changsha | Hunan | 410013 | China | Details | |
| Jiangsu Cancer Hospital ( Site 0719) | Nanjing | Jiangsu | 210000 | China | Details | |
| The First Hospital of Jilin University ( Site 0702) | Chang chun | Jilin | 130021 | China | Details | |
| Jilin Cancer Hospital ( Site 0705) | Changchun | Jilin | 130103 | China | Details | |
| Shanghai Chest Hospital ( Site 0700) | Shanghai | Shanghai | 200030 | China | Details | |
| Zhongshan Hospital Fudan University ( Site 0712) | Shanghai | Shanghai | 200433 | China | Details | |
| Tangdu Hospital ( Site 0708) | XI An | Shanxi | 710038 | China | Details | |
| The First Affiliated Hospital of Xi an Jiaotong University ( Site 0709) | XI An | Shanxi | 710061 | China | Details | |
| Affiliated Tumor Hospital of Xinjiang Medical University ( Site 0701) | Urumqi | Xinjiang | 830000 | China | Details | |
| The First Affiliated Hospital.Zhejiang University ( Site 0713) | Hangzhou | Zhejiang | 310003 | China | Details | |
| Sir Run Run Shaw Hospital School of Medicine, Zhejiang University ( Site 0715) | Hangzhou | Zhejiang | 310016 | China | Details | |
| Zhejiang Cancer Hospital ( Site 0716) | Hangzhou | Zhejiang | 310022 | China | Details | |
| Centre Leon Berard ( Site 0801) | Lyon | Auvergne | 69008 | France | Details | |
| CHU Caen Service de Pneumologie ( Site 0804) | Caen | Calvados | 14033 | France | Details | |
| Centre Georges Francois Leclerc ( Site 0809) | Dijon | Cote-d'Or | 21000 | France | Details | |
| Hopital Jean Minjoz Besancon ( Site 0805) | Besancon | Doubs | 25030 | France | Details | |
| Hopital Prive d'Antony ( Site 0811) | Antony | Hauts-de-Seine | 92160 | France | Details | |
| C.H.U. de Tours - Hopital Bretonneau ( Site 0806) | Tours | Indre-et-Loire | 37044 | France | Details | |
| Centre D Oncologie de Gentilly ( Site 0810) | Nancy | Meurthe-et-Moselle | 54100 | France | Details | |
| Clinique Victor Hugo ( Site 0802) | Le Mans | Sarthe | 72000 | France | Details | |
| CHU Poitiers ( Site 0803) | Poitiers | Vienne | 86021 | France | Details | |
| Robert Bosch Krankenhaus Klinik Schillerhoehe ( Site 0904) | Gerlingen | Baden-Wurttemberg | 70839 | Germany | Details | |
| Universitaetsklinikum Mannheim ( Site 0911) | Mannheim | Baden-Wurttemberg | 68167 | Germany | Details | |
| Klinikum Wuerzburg Mitte gGmbH ( Site 0901) | Wuerzburg | Bayern | 97074 | Germany | Details | |
| Pius Hospital Oldenburg ( Site 0905) | Oldenburg | Niedersachsen | 26121 | Germany | Details | |
| Florence Nightingale Krankenhaus ( Site 0912) | Duesseldorf | Nordrhein-Westfalen | 40489 | Germany | Details | |
| Kliniken Essen-Mitte ( Site 0900) | Essen | Nordrhein-Westfalen | 45136 | Germany | Details | |
| Universitaetsklinikum Muenster ( Site 0906) | Muenster | Nordrhein-Westfalen | 48149 | Germany | Details | |
| Medizinische Fakultaet Carl Gustav Carus der TU Dresden ( Site 0907) | Dresden | Sachsen | 01307 | Germany | Details | |
| Asklepios Klinikum Hamburg ( Site 0908) | Hamburg | 21075 | Germany | Details | ||
| Hong Kong Integrated Oncology Centre ( Site 0304) | Hong Kong | Hong Kong | Details | |||
| Queen Mary Hospital ( Site 0301) | Hong Kong | Hong Kong | Details | |||
| Queen Mary Hospital ( Site 0303) | Hong Kong | Hong Kong | Details | |||
| Hong Kong United Oncology Centre ( Site 0306) | Kowloon | Hong Kong | Details | |||
| Tuen Mun Hospital ( Site 0305) | Tuen Mun | Hong Kong | Details | |||
| Barzilai Medical Center ( Site 1706) | Ashkelon | HaDarom | 7830604 | Israel | Details | |
| Soroka Medical Center ( Site 1702) | Beer-Sheva | HaDarom | 8457108 | Israel | Details | |
| Meir Medical Center ( Site 1701) | Kfar-Saba | HaMerkaz | 4428164 | Israel | Details | |
| Rabin Medical Center ( Site 1704) | Petah Tikva | HaMerkaz | 4941492 | Israel | Details | |
| Ha Emek Medical Center ( Site 1707) | Afula | HaTsafon | 1834111 | Israel | Details | |
| Rambam Medical Center ( Site 1703) | Haifa | Heifa | 3109601 | Israel | Details | |
| Chaim Sheba Medical Center. ( Site 1700) | Ramat Gan | Tell Abib | 5265601 | Israel | Details | |
| Sourasky Medical Center ( Site 1705) | Tel Aviv | Tell Abib | 6423906 | Israel | Details | |
| Istituto Europeo di Oncologia ( Site 1303) | Milano | Lombardia | 20141 | Italy | Details | |
| Ospedale San Vincenzo di Taormina ( Site 1302) | Taormina | Messina | 98039 | Italy | Details | |
| AOU San Luigi Gonzaga di Orbassano ( Site 1300) | Orbassano | Torino | 10043 | Italy | Details | |
| IRCCS Giovanni Paolo II. Ospedale Oncologico ( Site 1305) | Bari | 70124 | Italy | Details | ||
| Azienda Ospedaliero Universitaria Careggi ( Site 1301) | Firenze | 50134 | Italy | Details | ||
| Azienda Ospedaliera dei Colli V. Monaldi ( Site 1306) | Napoli | 80131 | Italy | Details | ||
| Universita Campus Bio-Medico di Roma ( Site 1304) | Roma | 00128 | Italy | Details | ||
| National Hospital Organization Nagoya Medical Center ( Site 0608) | Nagoya | Aichi | 460-0001 | Japan | Details | |
| Aichi Cancer Center Hospital ( Site 0612) | Nagoya | Aichi | 464-8681 | Japan | Details | |
| Fujita Health University Hospital ( Site 0619) | Toyoake | Aichi | 470-1192 | Japan | Details | |
| National Cancer Center Hospital East ( Site 0601) | Kashiwa | Chiba | 277-8577 | Japan | Details | |
| National Hospital Organization Shikoku Cancer Center ( Site 0616) | Matsuyama | Ehime | 791-0280 | Japan | Details | |
| Hyogo Cancer Center ( Site 0604) | Akashi | Hyogo | 673-8558 | Japan | Details | |
| Kanazawa University Hospital ( Site 0617) | Kanazawa | Ishikawa | 920-8641 | Japan | Details | |
| Kanagawa Cancer Center ( Site 0609) | Yokohama | Kanagawa | 241-8515 | Japan | Details | |
| Kansai Medical University Hospital ( Site 0606) | Hirakata | Osaka | 573-1191 | Japan | Details | |
| Shizuoka Cancer Center Hospital and Research Institute ( Site 0602) | Sunto-gun | Shizuoka | 411-8777 | Japan | Details | |
| National Hospital Organization Kyushu Medical Center ( Site 0621) | Fukuoka | 810-8563 | Japan | Details | ||
| Kyushu University Hospital ( Site 0605) | Fukuoka | 812-8582 | Japan | Details | ||
| Niigata Cancer Center Hospital ( Site 0610) | Niigata | 951-8566 | Japan | Details | ||
| Okayama University Hospital ( Site 0614) | Okayama | 700-8558 | Japan | Details | ||
| Osaka International Cancer Institute ( Site 0611) | Osaka | 541-8567 | Japan | Details | ||
| National Cancer Center Hospital ( Site 0603) | Tokyo | 104-0045 | Japan | Details | ||
| Toranomon Hospital ( Site 0615) | Tokyo | 105-8470 | Japan | Details | ||
| Tokyo Metropolitan Komagome Hospital ( Site 0618) | Tokyo | 113-8677 | Japan | Details | ||
| Wakayama Medical University Hospital ( Site 0613) | Wakayama | 641-8510 | Japan | Details | ||
| Chungbuk National University Hospital ( Site 0404) | Cheongju si | Chungcheongbuk-do [Chungbuk] | 28644 | Korea, Republic of | Details | |
| Gachon University Gil Medical Center ( Site 0408) | Incheon | Incheon-gwangyeoksi [Incheon] | 21565 | Korea, Republic of | Details | |
| National Cancer Center ( Site 0400) | Gyeonggi-do | Kyonggi-do | 10408 | Korea, Republic of | Details | |
| Seoul National University Bundang Hospital ( Site 0405) | Seongnam-si | Kyonggi-do | 13620 | Korea, Republic of | Details | |
| Seoul National University Hospital ( Site 0402) | Seoul | Seoul-teukbyeolsi [Seoul] | 03080 | Korea, Republic of | Details | |
| Asan Medical Center ( Site 0407) | Seoul | Seoul-teukbyeolsi [Seoul] | 05505 | Korea, Republic of | Details | |
| Samsung Medical Center ( Site 0403) | Seoul | Seoul-teukbyeolsi [Seoul] | 06351 | Korea, Republic of | Details | |
| The Catholic University of Korea. Seoul St. Mary s Hospital ( Site 0406) | Seoul | Seoul-teukbyeolsi [Seoul] | 06591 | Korea, Republic of | Details | |
| Ulsan University Hospital ( Site 0401) | Ulsan | Ulsan-Kwangyokshi | 44033 | Korea, Republic of | Details | |
| Instituto Jaliscience de Cancerologia ( Site 2000) | Guadalajara | Jalisco | 44280 | Mexico | Details | |
| Medica Sur S.A.B de C.V. ( Site 2003) | Mexico City | 14050 | Mexico | Details | ||
| Oaxaca Site Management Organization SC ( Site 2001) | Oaxaca | 68000 | Mexico | Details | ||
| Instituto Nacional de Cancerologia. ( Site 2007) | Tlalpan | 14080 | Mexico | Details | ||
| Hospitalo Univ. Germans Trias i Pujol ( Site 1100) | Badalona | Barcelona [Barcelona] | 08916 | Spain | Details | |
| Hospital de la Santa Creu i Sant Pau ( Site 1102) | Barcelona | Barcelona [Barcelona] | 08025 | Spain | Details | |
| Hospital Universitari Vall d Hebron ( Site 1106) | Barcelona | Barcelona [Barcelona] | 08035 | Spain | Details | |
| Hospital Ramon y Cajal ( Site 1101) | Madrid | 28034 | Spain | Details | ||
| Hospital Universitario 12 de Octubre ( Site 1103) | Madrid | 28041 | Spain | Details | ||
| Complejo Hospitalario Carlos Haya de Malaga ( Site 1107) | Malaga | 29010 | Spain | Details | ||
| Hospital Universitario Virgen Macarena ( Site 1104) | Sevilla | 41009 | Spain | Details | ||
| Linkopings Universitetssjukhus ( Site 1504) | Linkoping | Ostergotlands Lan [se-05] | 581 85 | Sweden | Details | |
| Skanes Universitetssjukhus Lund ( Site 1503) | Lund | Skane Lan [se-12] | 221 85 | Sweden | Details | |
| Karolinska Universitetssjukhuset Solna ( Site 1500) | Solna | Stockholms Lan [se-01] | 171 64 | Sweden | Details | |
| Sahlgrenska Universitetssjukhuset ( Site 1502) | Goteborg | Vastra Gotalands Lan [se-14] | 413 45 | Sweden | Details | |
| Taipei Tzu Chi Hospital ( Site 0512) | New Taipei City | New Taipei | 231 | Taiwan | Details | |
| Changhua Christian Hospital ( Site 0509) | Changhua | 50006 | Taiwan | Details | ||
| National Taiwan University Hospital Hsin-Chu Branch ( Site 0511) | Hsinchu | 300 | Taiwan | Details | ||
| Hualien Tzu Chi Medical Center-Hospital ( Site 0510) | Hualien | 970 | Taiwan | Details | ||
| Kaohsiung Chang Gung Memorial Hospital ( Site 0507) | Kaohsiung | 833 | Taiwan | Details | ||
| Taipei Medical University Shuang Ho Hospital ( Site 0508) | New Taipei | 235 | Taiwan | Details | ||
| China Medical University Hospital ( Site 0505) | Taichung | 40447 | Taiwan | Details | ||
| Taichung Veterans General Hospital ( Site 0504) | Taichung | 40705 | Taiwan | Details | ||
| National Cheng Kung University Hospital ( Site 0506) | Tainan | 704 | Taiwan | Details | ||
| National Taiwan University Hospital ( Site 0500) | Taipei | 100 | Taiwan | Details | ||
| Mackay Memorial Hospital ( Site 0503) | Taipei | 104 | Taiwan | Details | ||
| Taipei Veterans General Hospital ( Site 0501) | Taipei | 11217 | Taiwan | Details | ||
| Chang Gung Medical Foundation. Linkou ( Site 0502) | Taoyuan | 333 | Taiwan | Details | ||
| Sussex University Hospitals ( Site 1003) | Brighton | Brighton And Hove | BN2 5BE | United Kingdom | Details | |
| Western General Hospital ( Site 1009) | Edinburgh | Edinburgh, City Of | EH4 2XU | United Kingdom | Details | |
| Leicester Royal Infirmary ( Site 1000) | Leicester | Leicestershire | LE1 5WW | United Kingdom | Details | |
| University College London Hospitals NHS Foundation Trust ( Site 1006) | London | London, City Of | NW1 2PG | United Kingdom | Details | |
| Chelsea & Westminster Hospital ( Site 1001) | London | London, City Of | SW10 9NH | United Kingdom | Details | |
| Birmingham Heartlands Hospital ( Site 1002) | Birmingham | B9 5SS | United Kingdom | Details | ||
| St James s University Hospital ( Site 1008) | Leeds | LS9 7TF | United Kingdom | Details | ||
| Barking Havering and Redbridge University Hospitals NHS Trust Queen s Hospital ( Site 1004) | Romford | RM7 0AG | United Kingdom | Details |