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| NCT ID | NCT03529110 |
| Title | DS-8201a Versus T-DM1 for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive, Unresectable and/or Metastatic Breast Cancer Previously Treated With Trastuzumab and Taxane [DESTINY-Breast03] |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Daiichi Sankyo, Inc. |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | ITA | GBR | FRA | ESP | DEU | CAN | BEL | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| UCLA Hematology Oncology | Los Angeles | California | 90095 | United States | Details | |
| Sharp Memorial Hospital | San Diego | California | 92123 | United States | Details | |
| University of California San Francisco | San Francisco | California | 94115 | United States | Details | |
| Innovative Clinical Research Institute | Whittier | California | 90603 | United States | Details | |
| Washington Cancer Institute | Washington | District of Columbia | 20010 | United States | Details | |
| Florida Cancer Specialists-Broadway | Fort Myers | Florida | 33916 | United States | Details | |
| Florida Cancer Specialists NORTH | Saint Petersburg | Florida | 33705 | United States | Details | |
| Piedmont Cancer Institute, PC | Atlanta | Georgia | 30318 | United States | Details | |
| Loyola University Health System | Maywood | Illinois | 60153 | United States | Details | |
| Norton Cancer Institute | Louisville | Kentucky | 40207 | United States | Details | |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02215 | United States | Details | |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198 | United States | Details | |
| North Shore Hematology Oncology Associates, PC | East Setauket | New York | 11733 | United States | Details | |
| University of Rochester | Rochester | New York | 14642 | United States | Details | |
| Wake Forest University Baptist Medical Center | Winston-Salem | North Carolina | 27157 | United States | Details | |
| University of Cincinnati Medical Center | Cincinnati | Ohio | 45267 | United States | Details | |
| Seidman Cancer Center | Cleveland | Ohio | 44106 | United States | Details | |
| The Ohio State University | Columbus | Ohio | 43210 | United States | Details | |
| Dayton Physicians, LLC | Kettering | Ohio | 45409 | United States | Details | |
| Magee-Womens Hospital of UPMC | Pittsburgh | Pennsylvania | 15213 | United States | Details | |
| Tennessee Oncology- St Thomas Location | Nashville | Tennessee | 37205 | United States | Details | |
| Vanderbilt Breast Center at One Hundred Oaks | Nashville | Tennessee | 37232 | United States | Details | |
| UT Southwestern Medical Center | Dallas | Texas | 75390 | United States | Details | |
| Houston Methodist Hospital / Houston Methodist Cancer Center | Houston | Texas | 77030 | United States | Details | |
| MD Anderson Cancer Center | Houston | Texas | 77030 | United States | Details | |
| Millennium Oncology | Houston | Texas | 77090 | United States | Details | |
| The University of Texas Health Science Center at Tyler | Tyler | Texas | 75708 | United States | Details | |
| MultiCare Health System Institute for Research and Innovation | Auburn | Washington | 98001 | United States | Details | |
| The Tweed Hospital | Tweed Heads | New South Wales | 2485 | Australia | Details | |
| Princess Alexandra Hospital | Woolloongabba | Queensland | 4102 | Australia | Details | |
| Box Hill Hospital | Box Hill | Victoria | 3128 | Australia | Details | |
| Peninsula and South Eastern Haematology & Oncology Group | Frankston | Victoria | 3199 | Australia | Details | |
| Peter MacCallum Cancer | Melbourne | Victoria | 3000 | Australia | Details | |
| St John of God Subiaco Hospital | Subiaco | Western Australia | 6008 | Australia | Details | |
| Institut Jules-Bordet | Bruxelles | 1000 | Belgium | Details | ||
| Universitair Ziekenhuis Brussel | Bruxelles | 1090 | Belgium | Details | ||
| Universitair Ziekenhuis Antwerpen | Edegem | 2650 | Belgium | Details | ||
| AZ Sint-Lucas - Campus Sint-Lucas | Gent | 9000 | Belgium | Details | ||
| Universitaire Ziekenhuizen Leuven | Leuven | 3000 | Belgium | Details | ||
| CHU UCL Namur site de Sainte Elisabeth | Namur | 5000 | Belgium | Details | ||
| NOB - Nucleo de Oncologia da Bahia | Salvador | Bahia | 40170-110 | Brazil | Details | |
| Hospital Nossa Senhora da Conceição | Porto Alegre | Rio Grande Do Sul | 91350-200 | Brazil | Details | |
| Catarina Pesquisa Clinica | Itajaí | Santa Catarina | 88301-220 | Brazil | Details | |
| CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia | Santo André | Sao Paulo | 09060-650 | Brazil | Details | |
| ICESP - Instituto do Cancer do Estado de São Paulo Octavio Frias de Oliveira | São Paulo | Sao Paulo | 01246-000 | Brazil | Details | |
| Clínica de Pesquisas e Centro de Estudos em Oncologia Ginecológica e Mamária Ltda. | São Paulo | Sao Paulo | 01317-001 | Brazil | Details | |
| Instituto Americas | Rio De Janeiro | 22793-080 | Brazil | Details | ||
| A. C. Camargo Cancer Center | São Paulo | 01509-900 | Brazil | Details | ||
| Tom Baker Cancer Centre | Calgary | Alberta | T2N 4N2 | Canada | Details | |
| Toronto Sunnybrook Hospital | Toronto | Ontario | M4N 3M5 | Canada | Details | |
| St. Mary's Hospital | Montréal | Quebec | H3T 1M5 | Canada | Details | |
| Cancer Hospital Chinese Academy of Medical Sciences | Beijing | Beijing | 100021 | China | Details | |
| Beijing Hospital | Beijing | Beijing | 100730 | China | Details | |
| Sun Yat-sen University, Cancer Center | Guangzhou | Guangdong | 510060 | China | Details | |
| Sun Yat-sen Memorial Hospital, Sun Yat-sen University | Guangzhou | Guangdong | 510120 | China | Details | |
| Harbin Medical University Cancer Hospital | Harbin | Heilongjiang | 150081 | China | Details | |
| The First Hospital of Jilin University | Chang chun | Jilin | 130021 | China | Details | |
| Liaoning Cancer Hospital & Institute | Shenyang | Liaoning | 110042 | China | Details | |
| Fudan University Shanghai Cancer Center | Shanghai | Shanghai | 200032 | China | Details | |
| West China Hospital, Sichuan University | Chengdu | Sichuan | 610041 | China | Details | |
| Tianjin Medical University Cancer Institute & Hospital | Tianjin | Tianjin | 300060 | China | Details | |
| Sir Run Run Shaw Hospital Xiasha Branch, Zhejiang University, School of Medicine | Hangzhou | Zhejiang | 310000 | China | Details | |
| Zhejiang Cancer Hospital | Hangzhou | Zhejiang | 310022 | China | Details | |
| Centre Paul Strauss | Strasbourg Cedex | Bas Rhin | 67000 | France | Details | |
| Hôpital Nord - CHU Marseille | Marseille Cedex 20 | Bouches-du-Rhone | 13915 | France | Details | |
| Centre François Baclesse | Caen Cedex 05 | Calvados | 14076 | France | Details | |
| Clinique Victor Hugo - Centre Jean Bernard | Le Mans | Cedex 02, Sarthe | 72015 | France | Details | |
| CARIO - Centre Armoricain de Radiothérapie, Imagerie médicale et Oncologie | Plérin | Cotes d'Armor | 22190 | France | Details | |
| Centre Georges François Leclerc | Dijon cedex | Côte-d'Or | 21079 | France | Details | |
| CHRU Jean Minjoz | Besançon | Doubs | 25030 | France | Details | |
| Institut Bergonié | Bordeaux cedex | Gironde | 33076 | France | Details | |
| Centre René Huguenin | Saint-Cloud | Hauts De Seine | 92110 | France | Details | |
| ICM Val d'Aurelle | Montpellier | Herault | 34298 | France | Details | |
| CRLCC Eugene Marquis | Rennes cedex | Ille Et Vilaine | 35042 | France | Details | |
| ICO - Site René Gauducheau | Saint-Herblain | Loire Atlantique | 44805 | France | Details | |
| ICO - Site Paul Papin | Angers Cedex 2 | Maine Et Loire | 49055 | France | Details | |
| Centre de cancerologie les Dentellieres | Valenciennes | Nord | 59300 | France | Details | |
| Centre Leon Berard | Lyon Cedex 08 | Rhone | 69373 | France | Details | |
| Centre Hospitalier Lyon Sud | Pierre Benite Cedex | Rhone | 69495 | France | Details | |
| Institut Sainte Catherine | Avignon Cedex 9 | Vaculuse | 84918 | France | Details | |
| Hôpital d'Instruction des Armees Begin | Saint-Mandé | Val De Marne | 94160 | France | Details | |
| Institut Gustave Roussy | Villejuif cedex | Val De Marne | 94805 | France | Details | |
| Institut Curie - site de Paris | Paris | 75005 | France | Details | ||
| Hôpital Saint-Louis | Paris | 75010 | France | Details | ||
| Hopital Tenon | Paris | 75020 | France | Details | ||
| Universitaetsklinikum Erlangen | Erlangen | Bayern | 91-54 | Germany | Details | |
| Rotkreuzklinikum Muenchen gGmbH | Muenchen | Bayern | 80637 | Germany | Details | |
| Klinikum rechts der Isar der TU Muenchen | Muenchen | Bayern | 81675 | Germany | Details | |
| Universitaetsklinikum Duesseldorf AoeR | Düsseldorf | Nordrhein Westfalen | 40225 | Germany | Details | |
| Haematologisch-Onkologische Schwerpunktpraxis | Troisdorf | Nordrhein Westfalen | 53840 | Germany | Details | |
| Marienhospital Bottrop gGmbH | Bottrop | Rheinland Pfalz | 46236 | Germany | Details | |
| Universitaetsklinikum Schleswig-Holstein - Campus Luebeck | Luebeck | Schleswig Holstein | 23538 | Germany | Details | |
| The Chinese | Hong Kong | 00000 | Hong Kong | Details | ||
| The University of Hong Kong | Shatin | 00000 | Hong Kong | Details | ||
| Azienda Ospedaliera Universitaria Arcispedale Sant'Anna | Cona | Ferrara | 44124 | Italy | Details | |
| Azienda Socio Sanitaria Territoriale di Monza (Presidio San Gerardo), U.O Oncologia Medica | Monza | Milano | 20900 | Italy | Details | |
| Istituto Clinico Humanitas | Rozzano | Milano | 20089 | Italy | Details | |
| IRCCS Centro di Riferimento Oncologico | Aviano | Pordenone | 33081 | Italy | Details | |
| Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII (Presidio Papa Giovanni XXIII) | Bergamo | 24127 | Italy | Details | ||
| Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi | Bologna | 40138 | Italy | Details | ||
| Istituto Nazionale per la Ricerca sul Cancro di Genova | Genova | 16132 | Italy | Details | ||
| Azienda Ospealiera della Provincia di Lecco | Lecco | 23900 | Italy | Details | ||
| Azienda Ospedaliera Ospedali Riuniti Papardo-Piemonte | Messina | 98158 | Italy | Details | ||
| Ospedale San Raffaele | Milano | 20132 | Italy | Details | ||
| IEO Istituto Europeo di Oncologia | Milano | 20141 | Italy | Details | ||
| A.O.U. Policlinico di Modena | Modena | 41124 | Italy | Details | ||
| Istituto Nazionale Tumori Fondazione G. Pascale | Napoli | 80131 | Italy | Details | ||
| Azienda Ospedaliero Universitaria di Parma | Parma | 43100 | Italy | Details | ||
| Fondazione IRCCS Policlinico San Matteo | Pavia | 27100 | Italy | Details | ||
| Azienda Ospedaliera Città della Salute e della Scienza di Torino | Torino | 10126 | Italy | Details | ||
| Center Hospital of the National Center for Global Health and Medicine | Shinjuku-Ku | Tokyo-To | 162-8655 | Japan | Details | |
| Aichi Cancer Center Hospital | Aichi | 464-8681 | Japan | Details | ||
| NHO Shikoku Cancer Center | Ehime | 791-0280 | Japan | Details | ||
| NHO Kyushu Cancer Center | Fukuoka | 811-1395 | Japan | Details | ||
| Hiroshima City Hiroshima Citizens Hospital | Hiroshima | 730-8518 | Japan | Details | ||
| NHO Hokkaido Cancer Center | Hokkaido | 003-0804 | Japan | Details | ||
| Kanagawa Cancer Center | Kanagawa | 241-8515 | Japan | Details | ||
| Kumamoto University Hospital | Kumamoto | 860-8556 | Japan | Details | ||
| Niigata Cancer Center | Niigata | 951-8566 | Japan | Details | ||
| Okayama University Hospital | Okayama | 700-8558 | Japan | Details | ||
| NHO Osaka National Hospital | Osaka | 540-0006 | Japan | Details | ||
| Osaka International Cancer Institute | Osaka | 541-8567 | Japan | Details | ||
| Saitama Cancer Center | Saitama | 362-0806 | Japan | Details | ||
| Shizuoka Cancer Center | Shizuoka | 411-8777 | Japan | Details | ||
| National Cancer Center Hospital | Tokyo | 104-0045 | Japan | Details | ||
| The Cancer Institute Hospital of JFCR | Tokyo | 135-8550 | Japan | Details | ||
| Showa University Hospital | Tokyo | 142-8666 | Japan | Details | ||
| Seoul National University Bundang Hospital | Seongnam-si | Gyeonggi-do | 13620 | Korea, Republic of | Details | |
| Seoul National University Hospital | Seoul | 03080 | Korea, Republic of | Details | ||
| Severance Hospital, Yonsei University | Seoul | 03722 | Korea, Republic of | Details | ||
| Asan Medical Center | Seoul | 05505 | Korea, Republic of | Details | ||
| Samsung Medical Center | Seoul | 06351 | Korea, Republic of | Details | ||
| ICO l'Hospitalet - Hospital Duran i Reynals | L'Hospitalet De Llobregat | Barcelona | 08908 | Spain | Details | |
| Complejo Hospitalario Universitario A Coruña | A Coruña | La Coruña | 15006 | Spain | Details | |
| Complejo Hospitalario Universitario de Santiago | Santiago De Compostela | La Coruña | 15706 | Spain | Details | |
| Hospital Universitario Puerta de Hierro Majadahonda | Majadahonda | Madrid | 28222 | Spain | Details | |
| Hospital Universitario Virgen Macarena | Sevilla | Sevill | 41009 | Spain | Details | |
| Hospital Universitario de Canarias | San Cristobal de la Laguna | Tenerife | 38320 | Spain | Details | |
| Hospital Infanta Cristina | Badajoz | 6007 | Spain | Details | ||
| Hospital Universitari Vall d'Hebron | Barcelona | 08035 | Spain | Details | ||
| Hospital Clinic de Barcelona | Barcelona | 08036 | Spain | Details | ||
| IOB-Institute of Oncology | Barcelona | 8023 | Spain | Details | ||
| Hospital General Universitario Gregorio Maranon | Madrid | 28007 | Spain | Details | ||
| MD Anderson Cancer Centre | Madrid | 28033 | Spain | Details | ||
| Hospital Universitario Ramon y Cajal | Madrid | 28034 | Spain | Details | ||
| Hospital Universitario Clinico San Carlos | Madrid | 28040 | Spain | Details | ||
| Hospital Universitario 12 de Octubre | Madrid | 28041 | Spain | Details | ||
| Hospital Clinico Universitario Virgen de la Victoria | Málaga | 29010 | Spain | Details | ||
| Hospital Universitario Virgen del Rocio | Sevilla | 41013 | Spain | Details | ||
| China Medical University Hospital | Taichung | 40447 | Taiwan | Details | ||
| National Cheng Kung University Hospital | Tainan | 704 | Taiwan | Details | ||
| National Taiwan University Hospital | Taipei | 100 | Taiwan | Details | ||
| Taipei Veterans General Hospital | Taipei | 11217 | Taiwan | Details | ||
| Koo Foundation, Sun Yat-Sen Cancer Center | Taipei | 112 | Taiwan | Details | ||
| Royal Devon and Exeter Hospital (Wonford) | Exeter | Devon | EX2 5DW | United Kingdom | Details | |
| Aberdeen Royal Infirmary | Aberdeen | Grampian Region | AB25 2ZB | United Kingdom | Details | |
| Queen Mary University of London | London | Greater London | EC1M 6BQ | United Kingdom | Details | |
| University College London Hospitals | London | Greater London | NW1 2PG | United Kingdom | Details | |
| Guy's Hospital | London | Greater London | SE1 9RY | United Kingdom | Details | |
| Sarah Cannon Research Institute UK | London | Greater London | W1G 6AD | United Kingdom | Details | |
| The Christie Hospital | Manchester | Greater Manchester | M20 4BX | United Kingdom | Details | |
| Western General Hospital | Edinburgh | Lothian Region | EH4 2XU | United Kingdom | Details | |
| Nottingham University Hospitals City Campus | Nottingham | Nottinghamshire | NG5 1PB | United Kingdom | Details | |
| Royal Surrey County Hospital | Guildford | Surrey | GU2 7XX | United Kingdom | Details |