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| NCT ID | NCT03731260 |
| Title | (PIONEER) Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, Versus Placebo in Patients With Indolent and Smoldering Systemic Mastocytosis |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase II |
| Variant Requirements | No |
| Sponsors | Blueprint Medicines Corporation |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | NLD | ITA | GBR | FRA | ESP | DEU | CAN | BEL |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | United States | Details | |
| Mayo Clinic Hospital | Phoenix | Arizona | 85054 | United States | Details | |
| Stanford Cancer Institute | Stanford | California | 94305 | United States | Details | |
| Mayo Clinic Florida | Jacksonville | Florida | 32224 | United States | Details | |
| H. Lee Moffitt Cancer Center | Tampa | Florida | 33612 | United States | Details | |
| Winship Cancer Institute, Emory University | Atlanta | Georgia | 30322 | United States | Details | |
| Rush University Medical Center | Chicago | Illinois | 60612 | United States | Details | |
| University of Kansas Hospital | Kansas City | Kansas | 66160 | United States | Details | |
| Brigham & Women's Hospital | Boston | Massachusetts | 02115 | United States | Details | |
| Dana Farber Cancer Institute | Boston | Massachusetts | 02215 | United States | Details | |
| Michigan Medicine, University of Michigan | Ann Arbor | Michigan | 48106 | United States | Details | |
| Mayo Clinic | Rochester | Minnesota | 55905 | United States | Details | |
| Washington University School of Medicine | Saint Louis | Missouri | 63110 | United States | Details | |
| Herbert Irving Comprehensive Cancer Center | New York | New York | 10032 | United States | Details | |
| Duke University Health System (DUHS) | Durham | North Carolina | 27710 | United States | Details | |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106 | United States | Details | |
| University of Texas, MD Anderson Cancer Center | Houston | Texas | 77030 | United States | Details | |
| Huntsman Cancer Institute | Salt Lake City | Utah | 84112 | United States | Details | |
| Virginia Commonwealth University Medical Center | Richmond | Virginia | 23298 | United States | Details | |
| University Hospital Antwerp | Edegem | 2650 | Belgium | Details | ||
| Tom Baker Cancer Centre | Calgary | Alberta | T2N 4N2 | Canada | Details | |
| University of Alberta Hospital | Edmonton | Alberta | T6G 2B7 | Canada | Details | |
| St. Michael's Hospital | Toronto | Ontario | M5B 1W8 | Canada | Details | |
| Odense Universitetshospital, ORCA/Allergicentret, Hudafdeling I og Allergicenter | Odense | DK-5000 | Denmark | Details | ||
| Hôpital de la Timone, Service de dermatologie | Marseille | 13385 | France | Details | ||
| Hôpital Pitié-Salpêtrière, Service de Dermatologie | Paris | 75013 | France | Details | ||
| CHU Toulouse Larrey, CEREMAST, Service de Dermatologie et Allergologie cutanée | Toulouse | 31059 | France | Details | ||
| Uniklinik RWTH Aachen | Aachen | 52074 | Germany | Details | ||
| Charité Universitätsmedizin Berlin | Berlin | 10117 | Germany | Details | ||
| University Clinic Hamburg Eppendorf, University Cancer Center Hamburg (UCCH) | Hamburg | 20246 | Germany | Details | ||
| Universitätsklinikum Schleswig-Holstein, Hämatologie/Onkologie | Lübeck | 23538 | Germany | Details | ||
| Universitätsklinik Mainz, Universitäts-Hautklinik, Clinical Research Center | Mainz | 55131 | Germany | Details | ||
| Universitätsmedizin Mannheim, III. Medizinische Klinik | Mannheim | 68167 | Germany | Details | ||
| Klinikum rechts der Isar, Technische Universität München | Munich | 80802 | Germany | Details | ||
| A.O.U di Bologna - IRCCS, Istituto di Ematologia Lorenzo e Ariosto Seragnoli, Ematologia | Bologna | 40138 | Italy | Details | ||
| Fondazione IRCCS Ca' Granda Ospedale Maggiore Poloclinico, UOC Ematologia | Milan | 20122 | Italy | Details | ||
| A.O. OO.RR. S.Giovanni di Dio e Ruggi d'Aragona, University of Salerno | Salerno | 84131 | Italy | Details | ||
| Azienda Ospedaliera Universitaria Integrata di Verona | Verona | 37126 | Italy | Details | ||
| University Medical Center Groningen (UMCG) | Groningen | 9713 GZ | Netherlands | Details | ||
| Erasmus Medical Center | Rotterdam | 3015 GD | Netherlands | Details | ||
| Oslo Universitetssykehus, Rikshospitalet, Department of Hematology | Oslo | 0372 | Norway | Details | ||
| Hospital Universitari Vall d'Hebron | Barcelona | 08035 | Spain | Details | ||
| lnstituto de Estudios de Mastocitosis de Castilla la Mancha, Hospital Virgen del Valle - Complejo Hospitalario de Toledo | Toledo | 45071 | Spain | Details | ||
| Karolinska University Hospital, Hematologimottagningen R51 | Stockholm | 141 86 | Sweden | Details | ||
| Akademiska sjukhuset, Hematologmottagningen/101A | Uppsala | 751 85 | Sweden | Details | ||
| University Hospital Basel | Basel | 4031 | Switzerland | Details | ||
| NHS Greater Glasgow and Clyde, Beatson West of Scotland Cancer Centre | Glasgow | G12 OXL | United Kingdom | Details | ||
| Guy's and St Thomas' NHS Foundation Trust - Guy's Hospital | London | SE1 9RT | United Kingdom | Details | ||
| Clatterbridge Cancer Centre NHS Foundation Trust | Wirral | CH63 4JY | United Kingdom | Details |