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NCT ID NCT03734029
Title Trastuzumab Deruxtecan (DS-8201a) Versus Investigator's Choice for HER2-low Breast Cancer That Has Spread or Cannot be Surgically Removed [DESTINY-Breast04]
Recruitment Active, not recruiting
Gender both
Phase Phase III
Variant Requirements No
Sponsors Daiichi Sankyo, Inc.
Indications

breast cancer

Therapies

Trastuzumab deruxtecan

Nab-paclitaxel

Capecitabine

Paclitaxel

Gemcitabine

Eribulin

Age Groups: senior | adult
Covered Countries USA | ITA | FRA | ESP | DEU | CAN | BEL | AUT

Facility Status City State Zip Country Details
Ironwood Cancer & Research Centers - Chandler II Chandler Arizona 85224 United States Details
Banner MD Anderson Cancer Center Gilbert Arizona 85234-2165 United States Details
Cancer Treatment Centers of America at Western Regional Medical Center Goodyear Arizona 85338 United States Details
UCLA School of Medicine Los Angeles California 90095-1690 United States Details
Stanford Cancer Institute Palo Alto California 94305 United States Details
Cancer Care Associates Medical Group, Inc. TORI Redondo Beach California 90277 United States Details
University of California at San Francisco (PARENT) San Francisco California 94158 United States Details
Eastern Connecticut Hematology/Oncology Assoc. Norwich Connecticut 06360 United States Details
Christiana Care Health Services, Inc. Newark Delaware 19713 United States Details
Sylvester Comprehensive Cancer Center - Deerfield Beach Boca Raton Florida 33426 United States Details
Florida Cancer Specialists (South Region) Fort Myers Florida 33916 United States Details
Memorial Healthcare System MRH Cancer Center Hollywood Florida 33021 United States Details
Orlando Health, Inc. Orlando Florida 32806 United States Details
Moffitt Cancer Center -Tampa Tampa Florida 33139 United States Details
Cancer Treatment Centers of America-Georgia Newnan Georgia 30263 United States Details
University of Chicago Medical Center Chicago Illinois 60637 United States Details
Cancer Treatment Centers of America Zion Illinois 60099 United States Details
Cancer Center of Kansas Wichita Kansas 67214 United States Details
Touro Infirmary New Orleans Louisiana 70115 United States Details
Dana-Farber Cancer Institute Boston Massachusetts 02215 United States Details
Henry Ford Hospital Detroit Michigan 48202 United States Details
Saint Luke's Hospital of Kansas City Kansas City Missouri 64111 United States Details
Saint Barnabas Medical Center Livingston New Jersey 07039 United States Details
New York University Medical Center New York New York 10016 United States Details
Memorial Sloan Kettering Hospital New York New York 10065-6007 United States Details
Weill Cornell Medicine Breast Center New York New York 10065 United States Details
The Cleveland Clinic Foundation Cleveland Ohio 44195 United States Details
Oregon Health & Science University Portland Oregon 97239 United States Details
Allegheny General Hospital Pittsburgh Pennsylvania 15212 United States Details
University of Pittsburgh Medical Center Health System Pittsburgh Pennsylvania 15219 United States Details
St Francis Hospital Greenville South Carolina 29601 United States Details
Brig Center for Cancer Care and Survivorship Knoxville Tennessee 37909 United States Details
Baptist Cancer Center Memphis Tennessee 38120 United States Details
Tennessee Oncology - Skyline Satellite Nashville Tennessee 37201 United States Details
BloomTrials Clinical Research, LLC Dallas Texas 75234 United States Details
The Methodist Hospital Research Institute Houston Texas 77030 United States Details
University of Texas M. D. Anderson Cancer Center - Investigational Cancer Therapeutics Houston Texas 77030 United States Details
Virginia Cancer Specialists Fairfax Virginia 22031 United States Details
Medizinische Universität Innsbruck Innsbruck 6020 Austria Details
Kepler Universitätsklinikum Linz 4020 Austria Details
LKH - Universitätsklinikum der PMU Salzburg Salzburg 5020 Austria Details
AKH - Medizinische Universität Wien (4305) Vienna 1090 Austria Details
Klinikum Wels-Grieskirchen GmbH Wels 4600 Austria Details
Institut Jules Bordet Bruxelles 1000 Belgium Details
Universitair Ziekenhuis Brussel Bruxelles 1090 Belgium Details
Cliniques Universitaires Saint-Luc Bruxelles 1200 Belgium Details
UZ Leuven Leuven 3000 Belgium Details
Grand Hôpital de Charleroi Loverval 6280 Belgium Details
CHU UCL Namur Namur 5000 Belgium Details
Centre Hospitalier Wallonie picarde - Site IMC Tournai 7500 Belgium Details
Tom Baker Cancer Center Calgary Alberta T2N4N2 Canada Details
Toronto Sunnybrook Hospital Toronto Ontario M4N 3M5 Canada Details
McGill University - Dept. Oncology Clinical Research Program Montréal Quebec H2W 1S6 Canada Details
Anhui Provincial Hospital Hefei Anhui 230001 China Details
Cancer Hospital Chinese Academy of Medical Sciences Beijing Beijing 100021 China Details
Chinese PLA General Hospital Beijing Beijing 100853 China Details
Fuzhou General Hospital of Nanjing Military Area Command of Chinese PLA Fuzhou Fujian 350025 China Details
Sun Yat-sen Memorial hospital, Sun Yat-sen University Guangzhou Guangdong 510120 China Details
Harbin Medical University Cancer Hospital Harbin Heilongjiang 150081 China Details
Hubei Cancer Hospital Wuhan Hubei 430079 China Details
The Affiliated Drum Tower Hospital of Nanjing University Nanjing Jiangsu 210008 China Details
The First Hospital of Jilin University Chang chun Jilin 130000 China Details
Jilin Cancer Hospital Chang chun Jilin 130012 China Details
Liaoning Cancer Hospital & Institute Shenyang Liaoning 110042 China Details
General Hospital of Ningxia Medical University Yinchuan Ningxia 750004 China Details
Linyi Cancer Hospital Linyi Shandong 276001 China Details
Shanghai General Hospital Shanghai Shanghai 200080 China Details
Fudan University Shanghai Cancer Center Shanghai Shanghai 20032 China Details
West China Hospital, Sichuan University Chengdu Sichuan 610041 China Details
Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine Hangzhou Zhejiang 310016 China Details
Zhejiang Cancer Hospital Hangzhou Zhejiang 310022 China Details
Institut Paoli Calmettes Marseille cedex 9 Bouches-du-Rhône 13009 France Details
Centre François Baclesse Caen Calvados 14076 France Details
CARIO - Centre Armoricain de Radiothérapie, Imagerie médicale et Oncologie Plérin Cotes d'Armor 22190 France Details
CHU Brest - Hôpital Morvan Brest Cedex Finistere 29609 France Details
Institut Bergonié Bordeaux cedex Gironde 33076 France Details
Clinique Clementville Montpellier Herault 34070 France Details
Institut Régional du Cancer de Montpellier Montpellier Herault 34298 France Details
CRLCC Eugene Marquis Rennes-cedex Ille Et Vilaine 35042 France Details
ICO - Site René Gauducheau Saint-Herblain Loire Atlantique 44805 France Details
Centre Hospitalier Emile Roux Le Puy-en-Velay Loiret 43012 France Details
ICO - Site Paul Papin Angers Cedex 2 Maine Et Loire 49055 France Details
Centre Hospitalier Valenciennes Valenciennes Nord 59322 France Details
Hôpital Saint-Louis - Paris Paris Cedex 10 Paris 75475 France Details
Clinique Victor Hugo - Centre Jean Bernard Le Mans Cedex 02 Sarthe 72015 France Details
Institut Sainte Catherine Avignon Cedex 9 Vaculuse 84918 France Details
Hôpital d'Instruction des Armees Begin* Saint Mande Val De Marne 94160 France Details
Institut Gustave Roussy Villejuif cedex Val De Marne 94805 France Details
Institut Curie - site de Paris Paris 75005 France Details
Hopital Tenon Paris 75020 France Details
Universitaetsklinikum Heidelberg Heidelberg Baden Wuerttemberg 69120 Germany Details
Klinikum der Universitaet Muenchen - Campus Grosshardern Munich Bayern 81377 Germany Details
General Hospital of Athens "Alexandra" Athens 11528 Greece Details
General Oncology Hospital of Kifissia " Agioi Anargyroi" Athens 14564 Greece Details
Athens Medical Center Athens 15125 Greece Details
University General Hospital of Heraklion Heraklion 71110 Greece Details
University General Hospital of Larissa Larissa 41110 Greece Details
Bioclinic Thessaloniki Thessaloníki 54622 Greece Details
Euromedica General Clinic Thessaloniki Thessaloníki 54645 Greece Details
General Hospital Papageorgiou Thessaloníki 56429 Greece Details
Interbalkan Hospital of Thessaloniki Thessaloníki 57001 Greece Details
Del-pesti Centrumkorhaz - Orszagos Hematologiai es Infektologiai Intezet Budapest 1097 Hungary Details
Orszagos Onkologiai Intezet Budapest 1122 Hungary Details
Debreceni Egyetem Debrecen 4032 Hungary Details
Bekes Megyei Kozponti Korhaz Pandy Kalman Tagkorhaza Gyula 5700 Hungary Details
SzSzB Megyei Korhazak es Egyetemi Oktatokorhaz Nyiregyhaza 4400 Hungary Details
Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz-Rendelointezet Szolnok 5004 Hungary Details
Rambam Health Care Center Haifa 3109601 Israel Details
Shaare Zedek Medical Center Jerusalem 9103102 Israel Details
Hadassah University Hospital - Ein Kerem Jerusalem 9112001 Israel Details
Rabin Medical Center-Beilinson Campus Petah tikva 49100 Israel Details
Chaim Sheba Medical Center Ramat Gan 52363 Israel Details
Kaplan Medical Center Rechovot 7610001 Israel Details
Ziv Medical Center Safed 13100 Israel Details
Tel Aviv Sourasky Medical Center Tel Aviv 6423906 Israel Details
Azienda Ospedaliera Card. G. Panico Tricase Lecce 73039 Italy Details
Azienda Socio Sanitaria Territoriale di Monza (Presidio San Gerardo) Monza Milano 20900 Italy Details
Istituto Clinico Humanitas Rozzano Milano 20089 Italy Details
Ospedale Sacro Cuore Don Calabria Negrar Verona 37024 Italy Details
Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi Bologna 40138 Italy Details
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili) Brescia 25100 Italy Details
Azienda Ospedaliera Univ. Policlinico Gaspare Rodolico Catania 95125 Italy Details
Azienda Ospedaliero Universitaria Mater Domini-Campus Universitario Catanzaro 88100 Italy Details
IEO Istituto Europeo di Oncologia Milano 20141 Italy Details
Istituto Nazionale Tumori Fondazione G. Pascale Napoli 80131 Italy Details
Ospedale degli Infermi Rimini 47923 Italy Details
Azienda Ospedaliera Universitaria Policlinico Tor Vergata Roma 00133 Italy Details
Fondazione Policlinico Universitario Agostino Gemelli IRCCS Roma 00168 Italy Details
Aichi Cancer Center Hospital Nagoya Aichi-Ken 464-8681 Japan Details
National Cancer Center Hospital East Kashiwa-shi Chiba-Ken 277-8577 Japan Details
NHO Shikoku Cancer Center Matsuyama-shi Ehime-Ken 791-0280 Japan Details
NHO Kyushu Cancer Center Fukuoka-shi Fukuoka-Ken 811-1395 Japan Details
Fukushima Medical University Hospital Fukushima Fukushima-Ken 960-1295 Japan Details
Hiroshima City Hiroshima Citizens Hospital Hiroshima-shi Hiroshima-Ken 730-8518 Japan Details
NHO Hokkaido Cancer Center Sapporo-shi Hokkaido 003-0804 Japan Details
Hyogo College of Medicine Hospital Nishinomiya-shi Hyogo-Ken 663-8501 Japan Details
Hakuaikai Sagara Hospital Kagoshima Kagoshima-Ken 892-0833 Japan Details
Tokai University Hospital Isehara Kanagawa-Ken 259-1193 Japan Details
Kanagawa Cancer Center Yokohama Kanagawa 241-8515 Japan Details
NHO Osaka National Hospital Osaka-shi Osaka-Fu 540-0006 Japan Details
Kindai University Hospital Onohigashi Osakasayama-shi 589-8511 Japan Details
Saitama Cancer Center Kitaadachi-gun Saitama-Ken 362-0806 Japan Details
Shizuoka Cancer Center Sunto-gun Shizuoka-Ken 411-8777 Japan Details
Cancer Institute Hospital of JFCR Koto-Ku Tokyo-To 135-8550 Japan Details
Toranomon Hospital Minato-Ku Tokyo-To 105-8470 Japan Details
Showa University Hospital Shinagawa-Ku Tokyo-To 142-8666 Japan Details
Chungbuk National University Hospital Cheongju-si Chungcheongbuk-do 361-711 Korea, Republic of Details
National Cancer Center Goyang-si Gyeonggi-do 10408 Korea, Republic of Details
Inha University Hospital Incheon Gyeonggi-do 22332 Korea, Republic of Details
Seoul National University Bundang Hospital Seongnam-si Gyeonggi-do 13620 Korea, Republic of Details
Ajou University Hospital Suwon Gyeonggi-do 16499 Korea, Republic of Details
Kyungpook National University Chilgok Hospital Daegu 41404 Korea, Republic of Details
Seoul National University Hospital Seoul 03080 Korea, Republic of Details
Asan Medical Center Seoul 05505 Korea, Republic of Details
Samsung Medical Center Seoul 06351 Korea, Republic of Details
The Catholic University of Korea, Seoul St. Mary's Hospital Seoul 06591 Korea, Republic of Details
Severance Hospital, Yonsei University Health System Seoul 120-752 Korea, Republic of Details
Hospital de Braga Braga 4710-243 Portugal Details
Centro Hospitalar do Alto do Ave, EPE Guimarães 4835-044 Portugal Details
Fundação Champalimaud Lisboa 1400-038 Portugal Details
Centro Hospitalar de Lisboa Norte, E.P.E. - Hospital de Santa Maria Lisboa 1649-035 Portugal Details
Unidade Local de Saúde de Matosinhos, EPE (Hospital Pedro Hispano) Matosinhos 4464-509 Portugal Details
Centro Hospitalar do Porto, E.P.E. - Hospital de Santo António Porto 4099-001 Portugal Details
Instituto Português de Oncologia do Porto Francisco Gentil, EPE Porto 4200-072 Portugal Details
Centro Hospitalar de Entre o Douro e Vouga, E.P.E - Hospital de São Sebastião Santa Maria Da Feira 4520-211 Portugal Details
Centro Hospitalar Vila Nova de Gaia/Espinho, E.P.E Vila Nova De Gaia 4434-502 Portugal Details
Centro Hospitalar de Trás-os-Montes e Alto Douro, EPE Vila Real 5000-508 Portugal Details
FSBSI "Russian Oncological Scientific Center n.a. N.N. Blokhin" Moscow 115478 Russian Federation Details
SBIH of Moscow City "Moscow City Oncology Hospital №62" of Moscow Healthcare Departement Moscow 143423 Russian Federation Details
SBIH of Yaroslavl Region "Regional Clinical Oncological Hospital" Yaroslavl 150054 Russian Federation Details
ICO l'Hospitalet - Hospital Duran i Reynals L'Hospitalet De Llobregat Barcelona 08908 Spain Details
Hospital Universitario Donostia San Sebastián Guipuzcoa 20014 Spain Details
Complejo Hospitalario Universitario A Coruña A Coruña La Coruña 15006 Spain Details
Hospital Universitario de Canarias San Cristobal de la Laguna Tenerife 38320 Spain Details
Hospital de Basurto Bilbao Vizcaya 48013 Spain Details
Hospital del Mar Barcelona 08003 Spain Details
Hospital Quironsalud Barcelona Barcelona 08023 Spain Details
Hospital Universitari Vall d'Hebron Barcelona 08035 Spain Details
Hospital Clinic de Barcelona Barcelona 08036 Spain Details
MD Anderson Cancer Centre Madrid 28033 Spain Details
Hospital Ruber Internacional Madrid 28034 Spain Details
Hospital Universitario Ramon y Cajal Madrid 28034 Spain Details
Hospital Universitario Clinico San Carlos Madrid 28040 Spain Details
Hospital Clinico Universitario Virgen de la Victoria Málaga 29010 Spain Details
Hospital Universitario Virgen Macarena Sevilla 41009 Spain Details
Hospital Universitario Virgen del Rocio Sevilla 41013 Spain Details
Instituto Valenciano de Oncologia IVO Valencia 46009 Spain Details
Hospital General Universitario de Valencia Valencia 46014 Spain Details
Karolinska universitetssjukhuset - Solna Solna 17176 Sweden Details
Länssjukhuset Sundsvall-Härnösand Sundsvall 85186 Sweden Details
Akademiska Sjukhuset Uppsala 75185 Sweden Details
Hirslanden Medical Center Aarau 5000 Switzerland Details
Universitaetsspital Basel Basel 4031 Switzerland Details
Kantonsspital Graubuenden Chur 7000 Switzerland Details
Centre Hospitalier Universitaire Vaudois Lausanne 1011 Switzerland Details
Kantonsspital St. Gallen Saint Gallen 9007 Switzerland Details
Kantonsspital Winterthur Winterthur 8401 Switzerland Details
Universitaetsspital Zuerich Zürich 8091 Switzerland Details
Kaohsiung Medical University Chung-Ho Memorial Hospital Kaohsiung 807 Taiwan Details
National Cheng Kung University Hospital Tainan 704 Taiwan Details
National Taiwan University Hospital Taipei 100 Taiwan Details
Royal Cornwall Hospital Truro Cornwall TR1 3LJ United Kingdom Details
Queen Mary University of London London Greater London EC1M 6BQ United Kingdom Details
University College London Hospitals London Greater London NW1 2PG United Kingdom Details
Royal Free Hospital London Greater London NW3 2QG United Kingdom Details
Western General Hospital Edinburgh Lothian Region EH4 2XU United Kingdom Details
Nottingham University Hospitals City Campus Nottingham Nottinghamshire NG5 1PB United Kingdom Details
Royal Surrey County Hospital Guildford Surrey GU2 7XX United Kingdom Details
*Shaded cells indicate that there was no data available from clincialtrials.gov for the field