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NCT ID NCT03797326
Title Efficacy and Safety of Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) in Previously Treated Participants With Select Solid Tumors (MK-7902-005/E7080-G000-224/LEAP-005)
Recruitment Active, not recruiting
Gender both
Phase Phase II
Variant Requirements No
Sponsors Merck Sharp & Dohme Corp.
Indications

ovarian cancer

colorectal cancer

stomach cancer

cholangiocarcinoma

gallbladder cancer

triple-receptor negative breast cancer

glioblastoma

Advanced Solid Tumor

Therapies

Lenvatinib + Pembrolizumab

Age Groups: adult | senior
Covered Countries USA | ITA | FRA | ESP | DEU | CAN

Facility Status City State Zip Country Details
City of Hope ( Site 0002) Duarte California 91010 United States Details
Cedars Sinai Medical Center ( Site 0003) Los Angeles California 90048 United States Details
University of California Davis Comprehensive Cancer Center ( Site 0005) Sacramento California 95817 United States Details
University of Colorado, Anschutz Cancer Pavilion ( Site 0007) Aurora Colorado 80045 United States Details
University of Florida-Health Cancer Center-Orlando ( Site 0015) Orlando Florida 32806 United States Details
Rutgers Cancer Institute of New Jersey ( Site 0009) New Brunswick New Jersey 08901 United States Details
Laura and Isaac Perlmutter Cancer Center at NYU Langone Health ( Site 0023) New York New York 10016 United States Details
Sanford Fargo Medical Center ( Site 0059) Fargo North Dakota 58102 United States Details
Lehigh Valley Hospital- Cedar Crest ( Site 0047) Allentown Pennsylvania 18103 United States Details
Sanford Cancer Center ( Site 0058) Sioux Falls South Dakota 57104 United States Details
West Cancer Center - East Campus ( Site 0018) Germantown Tennessee 38138 United States Details
Mary Crowley Cancer Research Centers - Medical City Hospital ( Site 0049) Dallas Texas 75230 United States Details
Swedish Medical Center ( Site 0021) Seattle Washington 98104 United States Details
University of Wisconsin Carbone Cancer Center ( Site 0017) Madison Wisconsin 53792-0001 United States Details
Fundacion Favaloro para la Docencia e Investigacion Medica ( Site 2106) Ciudad Autonoma de Buenos Aires Buenos Aires C1078AAI Argentina Details
Hospital Aleman ( Site 2100) Buenos Aires Caba 1118 Argentina Details
Hospital Britanico de Buenos Aires ( Site 2109) Ciudad de Buenos Aires Caba C1280AEB Argentina Details
Instituto de Oncologia de Rosario ( Site 2105) Rosario Santa Fe S2000KZE Argentina Details
CEMIC ( Site 2104) Buenos Aires C1431FWO Argentina Details
IDIM Instituto de Diagnostico e Investigaciones Metabolicas ( Site 2101) Caba C1012AAR Argentina Details
Royal Brisbane and Women s Hospital ( Site 0901) Herston Queensland 4029 Australia Details
Alfred Health ( Site 0902) Melbourne Victoria 3004 Australia Details
Sir Charles Gairdner Hospital ( Site 0903) Nedlands Western Australia 6009 Australia Details
BC Cancer - Abbotsford ( Site 0200) Abbotsford British Columbia V2S 0C2 Canada Details
CancerCare Manitoba ( Site 0201) Winnipeg Manitoba R3E 0V9 Canada Details
Hamilton Health Sciences-Juravinski Cancer Centre ( Site 0208) Hamilton Ontario L8V 4X2 Canada Details
Sunnybrook Research Institute ( Site 0207) Toronto Ontario M4N 3M5 Canada Details
Princess Margaret Cancer Centre ( Site 0202) Toronto Ontario M5G 2M9 Canada Details
Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0210) Montreal Quebec H2X 3E4 Canada Details
CHU de Quebec Universite de Laval ( Site 0206) Quebec G1R 2J6 Canada Details
Centro Investigación del Cáncer James Lind ( Site 1203) Temuco Araucania 4780000 Chile Details
Fundacion Arturo Lopez Perez ( Site 1201) Santiago Region M. De Santiago 7500921 Chile Details
Pontificia Universidad Catolica de Chile ( Site 1202) Santiago Region M. De Santiago 8330024 Chile Details
Hospital Clinico Universidad de Chile ( Site 1200) Santiago Region M. De Santiago 8380456 Chile Details
Fundacion Colombiana de Cancerologia Clinica Vida ( Site 1105) Medellin Antioquia 050030 Colombia Details
Instituto Nacional de Cancerologia E.S.E ( Site 1102) Bogota Distrito Capital De Bogota 110321 Colombia Details
Oncologos del Occidente S.A. ( Site 1106) Pereira Risaralda 660001 Colombia Details
Fundacion Valle del Lili ( Site 1101) Cali Valle Del Cauca 760032 Colombia Details
Centre Antoine Lacassagne ( Site 0404) Nice Alpes-Maritimes 06189 France Details
Centre Leon Berard ( Site 0405) Lyon Auvergne 69373 France Details
Institut Claudius Regaud IUCT Oncopole ( Site 0403) Toulouse Haute-Garonne 31059 France Details
Centre Oscar Lambret ( Site 0401) Lille Nord 59000 France Details
Institut de Cancerologie de l Ouest Centre Rene Gauducheau ( Site 0402) Saint-Herblain Val-de-Marne 44805 France Details
Institut Gustave Roussy ( Site 0400) Villejuif Val-de-Marne 94800 France Details
Robert Bosch GmbH ( Site 0307) Stuttgart Baden-Wurttemberg 70376 Germany Details
Universitaetsklinikum Regensburg ( Site 0304) Regensburg Bayern 93053 Germany Details
Universitaetsklinikum Frankfurt ( Site 0306) Frankfurt am Main Hessen 60528 Germany Details
HELIOS Dr. Horst Schmidt Kliniken Wiesbaden ( Site 0301) Wiesbaden Hessen 65199 Germany Details
SRH Wald-Klinikum Gera GmbH ( Site 0309) Gera Thuringen 07548 Germany Details
Universitaetsklinikum Jena ( Site 0302) Jena Thuringen 07740 Germany Details
Soroka Medical Center ( Site 0601) Beer Sheva 8457108 Israel Details
Rambam Medical Center ( Site 0602) Haifa 3109601 Israel Details
Hadassah Ein Kerem Medical Center ( Site 0604) Jerusalem 9112001 Israel Details
Chaim Sheba Medical Center ( Site 0600) Ramat Gan 5262000 Israel Details
Sourasky Medical Center ( Site 0603) Tel Aviv 6423906 Israel Details
Istituto Clinico Humanitas Research Hospital ( Site 1402) Rozzano Milano Italy Details
Policlinico Le Scotte - A.O. Senese ( Site 1401) Siena Toscana 53100 Italy Details
Istituto Nazionale Tumori Fondazione Pascale ( Site 1400) Napoli 80131 Italy Details
Fondazione Policlinico Universitario A. Gemelli ( Site 1403) Roma 00168 Italy Details
Asan Medical Center ( Site 1002) Songpagu Seoul 05505 Korea, Republic of Details
Seoul National University Hospital ( Site 1000) Seoul 03080 Korea, Republic of Details
Severance Hospital Yonsei University Health System ( Site 1001) Seoul 03722 Korea, Republic of Details
Arkhangelsk Clinical Oncological Dispensary ( Site 1600) Arkhangelsk Arkhangel Skaya Oblast 163045 Russian Federation Details
Russian Oncological Research Center n.a. N.N. Blokhin ( Site 1604) Moscow Moskva 115478 Russian Federation Details
Leningrad Regional Oncology Center ( Site 1609) Saint-Petersburg Sankt-Peterburg 188663 Russian Federation Details
Scientific Research Oncology Institute n.a. N.N.Petrov ( Site 1610) Saint-Petersburg Sankt-Peterburg 197758 Russian Federation Details
City Clinical Oncology Center ( Site 1608) Saint-Petersburg Sankt-Peterburg 198255 Russian Federation Details
Republican Clinical Oncology Dispensary of Tatarstan MoH ( Site 1603) Kazan Tatarstan, Respublika 420029 Russian Federation Details
Hospital Clinic i Provincial ( Site 0703) Barcelona 08036 Spain Details
Hospital Universitario Gregorio Maranon ( Site 0701) Madrid 28009 Spain Details
Clinica Universitaria de Navarra ( Site 0704) Madrid 28027 Spain Details
Hospital Ramon y Cajal ( Site 0702) Madrid 28034 Spain Details
Inselspital Universitaetsspital Bern ( Site 1705) Bern Berne 3010 Switzerland Details
Kantonsspital Graubuenden ( Site 1704) Chur Grisons 7000 Switzerland Details
Kantonsspital St. Gallen ( Site 1702) St. Gallen Sankt Gallen 9007 Switzerland Details
Ospedale Regionale di Bellinzona e Valli ( Site 1703) Bellinzona Ticino 6500 Switzerland Details
Hopitaux Universitaires de Geneve HUG ( Site 1701) Geneve 1211 Switzerland Details
Universitaetsspital Zurich ( Site 1700) Zurich 8091 Switzerland Details
National Cheng Kung University Hospital ( Site 3003) Tainan 704 Taiwan Details
National Taiwan University Hospital ( Site 3000) Taipei 10002 Taiwan Details
Chulalongkorn University ( Site 5001) Bangkok Krung Thep Maha Nakhon 10330 Thailand Details
Ramathibodi Hospital. ( Site 5002) Bangkok Krung Thep Maha Nakhon 10400 Thailand Details
Siriraj Hospital ( Site 5003) Bangkok Krung Thep Maha Nakhon 10700 Thailand Details
Cambridge University Hospitals NHS Trust ( Site 0803) Cambridge Cambridgeshire CB2 0QQ United Kingdom Details
Leicester Royal Infirmary. Univ. Hosp. of Leicester NHS Trust ( Site 0804) Leicester Leicestershire LE1 5WW United Kingdom Details
Guy's Hospital ( Site 0806) London London, City Of SE1 9RT United Kingdom Details
Royal Marsden Hospital (Sutton) ( Site 0800) London Surrey SM3 5PT United Kingdom Details
Christie NHS Foundation Trust ( Site 0805) Manchester M20 4BX United Kingdom Details
*Shaded cells indicate that there was no data available from clincialtrials.gov for the field