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NCT ID NCT03911869
Title An Open-Label, Randomized, Multicenter Trial of Encorafenib + Binimetinib Evaluating a Standard-dose and a High-dose Regimen in Patients With BRAFV600-mutant Melanoma Brain Metastasis (POLARIS)
Recruitment Recruiting
Gender both
Phase Phase II
Variant Requirements Yes
Sponsors Array BioPharma
Indications

melanoma

Therapies

Binimetinib + Encorafenib

Age Groups: adult | senior
Covered Countries USA | CAN

Facility Status City State Zip Country Details
California Cancer Associates for Research and Excellence Not yet recruiting Encinitas California 92024 United States Details
The Angeles Clinic And Research Institute, A Cedars-Sinai Affiliate Recruiting Los Angeles California 90025 United States Details
UC Irvine Health Not yet recruiting Orange California 92868 United States Details
West Coast Retina Not yet recruiting San Francisco California 94109 United States Details
San Francisco Oncology Associates Not yet recruiting San Francisco California 94115 United States Details
UCSF Helen Diller Family Comprehensive Cancer Center Recruiting San Francisco California 94143 United States Details
California Cancer Associates for Research and Excellence Not yet recruiting San Marcos California 92069 United States Details
The Retina Partners Recruiting Santa Monica California 90404 United States Details
Rocky Mountain Lions Eye Institute (RMLEI) Recruiting Aurora Colorado 80045 United States Details
University of Colorado Denver CTO/CTRC - Outpatient. Recruiting Aurora Colorado 80045 United States Details
University of Colorado Hospital - Anschutz Cancer Pavilion (ACP) Recruiting Aurora Colorado 80045 United States Details
University of Colorado Hospital - Anschutz Outpatient Pavilion Recruiting Aurora Colorado 80045 United States Details
University of Colorado Hospital Recruiting Aurora Colorado 80045 United States Details
Massachusetts Eye and Ear Infirmary(MEEI) Not yet recruiting Boston Massachusetts 02114 United States Details
Ophthalmic Consultants of Boston Inc (OCB) Not yet recruiting Boston Massachusetts 02114 United States Details
Massachusetts General Hospital Not yet recruiting Boston Massachusetts 22114 United States Details
Kellogg Eye Center - Ann Arbor Not yet recruiting Ann Arbor Michigan 48105 United States Details
University of Michigan Not yet recruiting Ann Arbor Michigan 48109 United States Details
Siteman Cancer Center - West County Not yet recruiting Creve Coeur Missouri 63141 United States Details
St. Luke's Hospital Not yet recruiting Kansas City Missouri 64111 United States Details
Washington University School of Medicine Not yet recruiting Saint Louis Missouri 63110-1032 United States Details
Barnes-Jewish Hospital Not yet recruiting Saint Louis Missouri 63110 United States Details
Washington University Infusion Center Pharmacy Not yet recruiting Saint Louis Missouri 63110 United States Details
Siteman Cancer Center - South County Not yet recruiting Saint Louis Missouri 63129 United States Details
Bio-Reference Laboratories Inc Recruiting Elmwood Park New Jersey 07407-3118 United States Details
Hackensack University Medical Center Not yet recruiting Hackensack New Jersey 07601 United States Details
Atlantic Health System, Morristown Medical Center Not yet recruiting Morristown New Jersey 07962 United States Details
Metro Eye Care Not yet recruiting Paramus New Jersey 07417 United States Details
St Lukes Warren Physician Group Pc Not yet recruiting Phillipsburg New Jersey 08865 United States Details
St. Luke's Hospital- Warren Campus Not yet recruiting Phillipsburg New Jersey 08865 United States Details
Dr. John M. Boozan, MD Not yet recruiting Summit New Jersey 07901 United States Details
Karen Connolly, MD Not yet recruiting West Orange New Jersey 07052 United States Details
NYU Investigational Pharmacy Not yet recruiting New York New York 10016 United States Details
NYU Langone Faculty Group Practice Not yet recruiting New York New York 10016 United States Details
NYU Langone Health Not yet recruiting New York New York 10016 United States Details
Ohio State University Comprehensive Cancer Center Not yet recruiting Columbus Ohio 43202 United States Details
Ohio State University James Cancer Hospital and Solove Research Institute Not yet recruiting Columbus Ohio 43210 United States Details
Ohio State University Wexner Medical Center Not yet recruiting Columbus Ohio 43210 United States Details
Ohio State Eye and Ear Institute Not yet recruiting Columbus Ohio 43212 United States Details
Ohio State University James Cancer Hospital Martha Morehouse Medical Center Not yet recruiting Columbus Ohio 43221 United States Details
Knight Cancer Institute Hematology Oncology Recruiting Beaverton Oregon 97006 United States Details
Knight Cancer Institute Hematology Oncology - Gresham Clinic Recruiting Gresham Oregon 97030 United States Details
Knight Cancer Institute Hematology Oncology - Northwest Clinic Recruiting Portland Oregon 97210 United States Details
Kniht acer Intitute Hematology Oncology - East Portland Clinic Recruiting Portland Oregon 97216 United States Details
Oregon Health & Science University Center for Health & Healing 2 Recruiting Portland Oregon 97239-3011 United States Details
OHSU Center for Health and Healing Recruiting Portland Oregon 97239 United States Details
OHSU Laboratory Services Recruiting Portland Oregon 97239 United States Details
Knight Cancer Institute Hematology Oncology - Tualatin Clinic Recruiting Tualatin Oregon 97062 United States Details
St. Luke's Hospital - Allentown Campus Not yet recruiting Allentown Pennsylvania 18104 United States Details
St. Luke's Hematology Oncology Specialists Not yet recruiting Bethlehem Pennsylvania 18015 United States Details
St. Luke's Hospital-Bethlehem Campus Not yet recruiting Bethlehem Pennsylvania 18015 United States Details
Bethlehem Eye Associates Not yet recruiting Bethlehem Pennsylvania 18018 United States Details
St. Luke's Hospital- Miners Campus Not yet recruiting Coaldale Pennsylvania 18218 United States Details
St. Luke's Hematology Oncology Specialists Not yet recruiting Easton Pennsylvania 18045 United States Details
St. Luke's Hospital- Anderson Campus Not yet recruiting Easton Pennsylvania 18045 United States Details
UPMC Eye and Ear Institute Not yet recruiting Pittsburgh Pennsylvania 15213 United States Details
UPMC Hillman Cancer Center Not yet recruiting Pittsburgh Pennsylvania 15232 United States Details
UPMC Shadyside Hospital Not yet recruiting Pittsburgh Pennsylvania 15232 United States Details
St. Luke's Hospital- Quakertown Campus Not yet recruiting Quakertown Pennsylvania 18951 United States Details
St. Luke's Hospital- Monroe Campus Not yet recruiting Stroudsburg Pennsylvania 18360 United States Details
Henry-Joyce Cancer Clinic Not yet recruiting Nashville Tennessee 37232 United States Details
MD Anderson Cancer Center Recruiting Houston Texas 77030 United States Details
University of Utah - Huntsman Cancer Institute - PPDS Not yet recruiting Salt Lake City Utah 84112-5550 United States Details
University of Utah, Huntsman Cancer Hospital Not yet recruiting Salt Lake City Utah 84112 United States Details
University of Utah, Moran Eye Center Not yet recruiting Salt Lake City Utah 84132 United States Details
University of Wisconsin Carbone Cancer Center Not yet recruiting Madison Wisconsin 53792-0001 United States Details
University of Wisconsin Carbone Cancer Center Not yet recruiting Madison Wisconsin 53792 United States Details
Instituto Médico Especializado Alexander Fleming Recruiting Buenos Aires Ciudad Autónoma DE Buenosaires CP1426ANZ Argentina Details
Iict Labs Sa Recruiting Rosario Santa FE 2000 Argentina Details
Centro de Imágenes Médicas - Clinica de Cámara Gamma Recruiting Rosario Santa FE S2000AMT Argentina Details
CICOR (rosario) Recruiting Rosario Santa FE S2000DSK Argentina Details
Instituto de Oncologia de Rosario Recruiting Rosario Santa FE S2000KZE Argentina Details
Fundacion CIDEA Not yet recruiting Caba C1121ABE Argentina Details
Micro Cirugia Ocular Rosario Recruiting Rosario Argentina Details
Coffs Harbour Health Campus Not yet recruiting Coffs Harbour New South Wales 2450 Australia Details
Crows Nest Eye Surgery Recruiting Crows Nest New South Wales 2065 Australia Details
Melanoma Institute Australia Recruiting North Sydney New South Wales 2060 Australia Details
Royal north shore center hospital dermatology clinics Recruiting st Leonards New South Wales 2065 Australia Details
Mater Imaging Recruiting Wollstonecraft New South Wales 2065 Australia Details
Royal Adelaide Hospital Not yet recruiting Adelaide South Australia 5000 Australia Details
Flinders Medical Centre Not yet recruiting Adelaide South Australia 5042 Australia Details
South Australian Medical Imaging Not yet recruiting Bedford park South Australia 5042 Australia Details
Radiology SA Not yet recruiting Seacombe Gardens South Australia 5047 Australia Details
Peter MacCallum Cancer Centre Not yet recruiting Melbourne Victoria 3000 Australia Details
Lions Eye Institute Not yet recruiting Nedlands Western Australia 6009 Australia Details
Affinity Clinical Research Not yet recruiting Nedlands 6009 Australia Details
Algemeen Ziekenhuis Klina Not yet recruiting Brasschaat Antwerpen 2930 Belgium Details
GasthuisZusters Antwerpen Not yet recruiting Wilrijk Antwerpen 2610 Belgium Details
UZ Antwerpen Pharmacy Recruiting Edegem 2650 Belgium Details
AZ Groeninge Not yet recruiting Kortrijk 8500 Belgium Details
Alberta Cancer Board Not yet recruiting Edmonton Alberta T5J3N4 Canada Details
Alberta Health Services - Cross Cancer Institute Not yet recruiting Edmonton Alberta T6G 1Z2 Canada Details
Health Sciences Centre Not yet recruiting Winnepeg Manitoba R3A 1R9 Canada Details
St. Boniface Hospital Inc. Not yet recruiting Winnepeg Manitoba R3E 0V9 Canada Details
Manitoba Clinic Not yet recruiting Winnipeg Manitoba R3A 1M3 Canada Details
CancerCare Manitoba Not yet recruiting Winnipeg Manitoba R3E 0V9 Canada Details
Dr. Everett Chalmers Regional Hospital Not yet recruiting Fredericton New Brunswick E3B 5N5 Canada Details
Dipartimento di Tecnologie Avanzate Diagnostico-Terapeutiche - responsible Dr. Angelo Vanzulli Not yet recruiting Milano Milan 20162 Italy Details
ASST Grande Ospedale Metropolitano Niguarda Not yet recruiting Milano MI 20162 Italy Details
Azienda Universitaria Policlinico Federico II Recruiting Napoli Naples 80131 Italy Details
Istituto Scientifico Romagnolo Per Lo Studio E La Cura Dei Tumori IRST - PPDS Not yet recruiting Meldola (FC) Reggio Emilia 47014 Italy Details
Azienda Ospedale Università Padova - Dipartimento Salute della Donna e del Bambino Not yet recruiting Padova Veneto 35128 Italy Details
Istituto Oncologico Veneto - I.R.C.C.S. Not yet recruiting Padova Veneto 35128 Italy Details
Oncologia Medica - IRCCS Ospedale San Raffaele S.r.l. Not yet recruiting Milano 20132 Italy Details
Servizio di Farmacia - IRCCS Ospedale San Raffaele S.r.l. Not yet recruiting Milano 20132 Italy Details
Unita Dermatologia e Cosmetologia - IRCCS Ospedale San Raffaele S.r.l. Not yet recruiting Milano 20132 Italy Details
UO Anatomia Patologica - IRCCS Ospedale San Raffaele S.r.l. Not yet recruiting Milano 20132 Italy Details
UO Cardiologia - IRCCS Ospedale San Raffaele S.r.l. Not yet recruiting Milano 20132 Italy Details
UO di Oculistica - IRCCS Ospedale San Raffaele S.r.l. Not yet recruiting Milano 20132 Italy Details
UO Medicina Nucleare - IRCCS Ospedale San Raffaele S.r.l. Not yet recruiting Milano 20132 Italy Details
UO Neuro Radiologia - IRCCS Ospedale San Raffaele S.r.l. Not yet recruiting Milano 20132 Italy Details
UO Radiologia - IRCCS Ospedale San Raffaele S.r.l. Not yet recruiting Milano 20132 Italy Details
Medicina Nucleare - Dipartimento Tecnologie Avanzate Diagnostico Terapeutiche Not yet recruiting Milano 20162 Italy Details
S.C Oculistica - Padiglione 3 e/o Blocco Sud, Responsible Dr. Marcelo Pisani Not yet recruiting Milano 20162 Italy Details
S.C. Cardiologia 4 - Diagnostica e Riabilitativa - Padiglione Blocco SUD responsible Prof. Cristina Not yet recruiting Milano 20162 Italy Details
SC Farmacia - Polo Logistico - responsible Dr. Massimo Medaglia Not yet recruiting Milano 20162 Italy Details
Istituto Europeo di Oncologia Not yet recruiting Milan 20141 Italy Details
S.C. Cardiologia Recruiting Napoli 80131 Italy Details
S.C. Farmacia Recruiting Napoli 80131 Italy Details
S.C. Medicina Nucleare e Terapia Metabolica Recruiting Napoli 80131 Italy Details
SC Melanoma, Immunoterapia Oncologica e Terapie Innovative Recruiting Napoli 80131 Italy Details
U.O. Radiodiagnostica 1 Recruiting Napoli 80131 Italy Details
Azienda Ospedaliera Città della Salute e della Scienza di Torino Not yet recruiting Torino 10126 Italy Details
Farmacia Ospedaliera Azienda Ospedaliera Universitaria - Città della Salute e della Scienza di Tori Not yet recruiting Torino 10126 Italy Details
Medicina Nucleare Azienda Ospedaliera Universitaria Not yet recruiting Torino 10126 Italy Details
Radiologia 2 Azienda Ospedaliera Universitaria - Città della Salute e della Scienza di Torino Not yet recruiting Torino 10126 Italy Details
S. C. Dermatologia U Azienda Ospedaliera Universitaria Not yet recruiting Torino 10126 Italy Details
Oculistica Universitaria Padiglione Dermatologico San Lazzaro Azienda Ospedaliera Universitaria Not yet recruiting Torino 20126 Italy Details
S.C. MEDICINA INTERNA 4 U Azienda Ospedaliera Universitaria Not yet recruiting Torino 20126 Italy Details
Medisch Spectrum Twente Not yet recruiting Enschede Overijssel 7512 KZ Netherlands Details
Leids Universitair Medisch Centrum Not yet recruiting Leiden 2333 ZA Netherlands Details
Wellington Hospital Not yet recruiting Wellington South Wellington 6021 New Zealand Details
Capital Eye Specialists Not yet recruiting Wellington 6011 New Zealand Details
*Shaded cells indicate that there was no data available from clincialtrials.gov for the field