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NCT ID NCT04008030
Title A Study of Nivolumab, Nivolumab Plus Ipilimumab, or Investigator's Choice Chemotherapy for the Treatment of Patients With Deficient Mismatch Repair (dMMR)/Microsatellite Instability High (MSI-H) Metastatic Colorectal Cancer (mCRC) (CheckMate 8HW))
Recruitment Recruiting
Gender both
Phase Phase III
Variant Requirements No
Sponsors Bristol-Myers Squibb
Indications

colorectal cancer

Therapies

Nivolumab

Fluorouracil + Irinotecan + Leucovorin

Cetuximab

Fluorouracil + Leucovorin + Oxaliplatin

Bevacizumab

Ipilimumab + Nivolumab

Age Groups: senior | adult
Covered Countries USA | ITA | FRA | ESP | DEU | CAN | BEL | AUT

Facility Status City State Zip Country Details
Local Institution Withdrawn Gilbert Arizona 85234 United States Details
Usc/Norris Comprehensive Cancer Center Recruiting Los Angeles California 90033 United States Details
University of California Davis Health-University of California Davis Comprehensive Cancer Center Recruiting Sacramento California 95817 United States Details
Rocky Mountain Cancer Centers Recruiting Denver Colorado 80218 United States Details
Local Institution Withdrawn Miami Florida 33136 United States Details
Local Institution Withdrawn Marietta Georgia 30060 United States Details
Illinois Cancer Specialists Recruiting Arlington Heights Illinois 60005 United States Details
Memorial Sloan Kettering Nassau Recruiting New York New York 10065 United States Details
Northwest Cancer Specialists, P.C. Recruiting Portland Oregon 97227 United States Details
Local Institution Withdrawn Philadelphia Pennsylvania 19104 United States Details
UPMC Hillman Cancer Center Recruiting Pittsburgh Pennsylvania 15232 United States Details
Texas Oncology Sammons Cancer Center Recruiting Dallas Texas 75246 United States Details
Local Institution Withdrawn Fort Worth Texas 76104 United States Details
Oncology & Hematology Associates Of Southwest Virginia, Inc. Recruiting Roanoke Virginia 24014 United States Details
Local Institution - 0073 Recruiting Ciudad Autonoma Beunos Aires Buenos Aires 1431 Argentina Details
Local Institution - 0074 Recruiting Viedma RIO Negro 8500 Argentina Details
Local Institution Not yet recruiting San Miguel de Tucumán Tucuman T4000 Argentina Details
Local Institution - 0084 Recruiting Buenos Aires 1093 Argentina Details
Local Institution - 0100 Recruiting Caba 1199 Argentina Details
Local Institution - 0072 Recruiting Caba 1426 Argentina Details
Local Institution - 0019 Recruiting Westmead New South Wales 2145 Australia Details
Local Institution - 0053 Recruiting Woolloongabba Queensland 4102 Australia Details
Local Institution - 0018 Recruiting Elizabeth Vale South Australia 5112 Australia Details
Local Institution - 0041 Recruiting Clayton Victoria 3168 Australia Details
Local Institution - 0017 Recruiting Heidelberg Victoria 3084 Australia Details
Lkh-Univ.Klinikum Graz Recruiting Graz 8036 Austria Details
Local Institution - 0068 Recruiting Linz 4010 Austria Details
Local Institution - 0120 Recruiting Salzburg 5020 Austria Details
Local Institution - 0067 Recruiting Wiener Neustadt 2700 Austria Details
Local Institution - 0065 Recruiting Wien 1090 Austria Details
Local Institution - 0045 Recruiting Bonheiden 2820 Belgium Details
Local Institution Withdrawn Brussel 1090 Belgium Details
Local Institution - 0025 Recruiting Bruxelles 1000 Belgium Details
Local Institution - 0024 Recruiting Leuven 3000 Belgium Details
Local Institution - 0096 Recruiting Ipatinga Minas Gerais 35160-158 Brazil Details
Local Institution Not yet recruiting Natal RIO Grande DO Norte 59075-740 Brazil Details
Local Institution - 0192 Recruiting Porto Alegre RIO Grande DO SUL 91350-200 Brazil Details
Local Institution - 0102 Recruiting Barretos Sao Paulo 14780-070 Brazil Details
Local Institution - 0094 Recruiting São José do Rio Preto São Paulo 15090000 Brazil Details
Local Institution - 0199 Recruiting Rio de Janeiro 20231-050 Brazil Details
Local Institution - 0095 Recruiting Sao Paulo 01509-900 Brazil Details
Local Institution - 0193 Recruiting São Paulo 01246-000 Brazil Details
Local Institution - 0011 Recruiting Edmonton Alberta T6G 1Z2 Canada Details
Local Institution - 0039 Active, not recruiting Vancouver British Columbia V5Z 4E6 Canada Details
Local Institution Withdrawn Halifax Nova Scotia B3H 2Y9 Canada Details
Local Institution - 0013 Recruiting Toronto Ontario M5G 1X5 Canada Details
Local Institution - 0016 Recruiting Montreal Quebec H2X 3E4 Canada Details
Local Institution - 0015 Recruiting Sherbrooke Quebec J1H 5N4 Canada Details
Local Institution Withdrawn Quebec G1R 2J6 Canada Details
Local Institution - 0071 Recruiting Santiago Metropolitana 7500921 Chile Details
Local Institution - 0069 Recruiting Santiago Metropolitana 8320000 Chile Details
Local Institution - 0070 Recruiting Independencia Santiago Chile Details
Local Institution - 0146 Recruiting Hefei Anhui 230061 China Details
Local Institution Not yet recruiting Fuzhou Fujian 350001 China Details
Local Institution - 0163 Recruiting Xiamen Fujian 361003 China Details
Local Institution - 0207 Recruiting Zhangzhou Fujian 363000 China Details
Local Institution - 0211 Recruiting Lanzhou Gansu 730030 China Details
Local Institution - 0158 Recruiting Foshan Guangdong 528000 China Details
Local Institution Recruiting Guangzhou Guangdong 510080 China Details
Local Institution Recruiting Guangzhou Guangdong 510095 China Details
Local Institution - 0149 Recruiting Guangzhou Guangdong 510655 China Details
Local Institution Recruiting Nanning Guangxi 530000 China Details
Local Institution - 0196 Recruiting Nanning Guangxi 530021 China Details
Local Institution - 0180 Recruiting Harbin Heilongjiang 150040 China Details
Local Institution Recruiting Zhengzhou Henan 450052 China Details
Local Institution Not yet recruiting Changsha Hunan 410013 China Details
Local Institution - 0145 Recruiting Changzhou Jiangsu 213003 China Details
Local Institution - 0151 Recruiting Nanchang Jiangxi 330006 China Details
Local Institution - 0164 Recruiting Changchun Jilin 130021 China Details
Local Institution - 0162 Recruiting Shenyang Liaoning 110042 China Details
Local Institution - 0188 Recruiting Xi'an Shaanxi 710126 China Details
Local Institution - 0210 Recruiting Jinan Shandong 250117 China Details
Local Institution - 0212 Recruiting Linyi Shandong 276034 China Details
Local Institution Recruiting Qingdao Shandong 266061 China Details
Local Institution - 0165 Recruiting Yantai Shandong 264000 China Details
Local Institution - 0143 Recruiting Shanghai Shanghai 200080 China Details
Local Institution - 0131 Recruiting Shanghai Shanghai 200120 China Details
Local Institution Not yet recruiting Kunming Yunnan 650118 China Details
Local Institution - 0137 Recruiting Hangzhou Zhejiang 310009 China Details
Local Institution Not yet recruiting Ningbo Zhejiang 315041 China Details
Local Institution - 0087 Recruiting Brno 656 53 Czechia Details
Local Institution - 0085 Recruiting Hradec Kralove 500 05 Czechia Details
Local Institution - 0088 Recruiting Novy Jicin 741 01 Czechia Details
Local Institution - 0086 Recruiting Olomouc 779 00 Czechia Details
Local Institution - 0038 Recruiting Herlev 2730 Denmark Details
Local Institution Withdrawn Odense 5000 Denmark Details
Local Institution - 0036 Recruiting Vejle 7100 Denmark Details
Local Institution - 0176 Recruiting Limoges Haute-Vienne 87042 France Details
Centre Hospitalier de la Côte Basque-Hepato-Gastro-Enterology Recruiting Bayonne 64100 France Details
Local Institution - 0028 Recruiting Besancon Cedex 25030 France Details
Local Institution - 0138 Recruiting Lille 59000 France Details
Local Institution - 0029 Recruiting Lyon Cedex 08 69373 France Details
Hopital Prive Jean Mermoz Recruiting Lyon 69008 France Details
Local Institution - 0066 Recruiting Marseille 13005 France Details
Local Institution - 0030 Recruiting Montpellier 34298 France Details
Local Institution - 0032 Recruiting Nantes 44093 France Details
Local Institution - 0027 Recruiting Paris 75012 France Details
Local Institution - 0061 Recruiting Pessac Cedex 33604 France Details
Local Institution - 0031 Recruiting Poitiers 86000 France Details
Local Institution Withdrawn Rouen 76000 France Details
ICANS-Institut de cancerologie Strasbourg Europe Recruiting Strasbourg 67200 France Details
Local Institution - 0040 Recruiting Toulouse 31059 France Details
Local Institution - 0042 Recruiting Dresden 01307 Germany Details
Local Institution - 0007 Recruiting Essen 45122 Germany Details
Local Institution - 0043 Recruiting Hamburg 20249 Germany Details
Local Institution - 0117 Recruiting Hamburg 22763 Germany Details
Local Institution - 0008 Recruiting Hannover 30625 Germany Details
Local Institution - 0009 Recruiting Heidelberg 69120 Germany Details
Local Institution - 0044 Recruiting Marburg 35043 Germany Details
Local Institution - 0010 Recruiting Munich 81377 Germany Details
Local Institution - 0123 Recruiting Athens 11528 Greece Details
Local Institution - 0125 Recruiting Heraklion 71110 Greece Details
Local Institution - 0124 Recruiting Holargos 15562 Greece Details
Local Institution - 0126 Recruiting Ioannina 45500 Greece Details
Local Institution - 0091 Recruiting Dublin 8 Dublin Ireland Details
Local Institution Recruiting Dublin Ireland Details
Local Institution Recruiting Limerick V94 F858 Ireland Details
PO Garibaldi Nesima AORN Garibaldi Recruiting Catania 95122 Italy Details
Local Institution Recruiting Genova 16132 Italy Details
ASST Grande Ospedale Niguarda Recruiting Milan 20162 Italy Details
AOU della Campania Luigi Vanvitelli Recruiting Napoli 80131 Italy Details
I.O.V. Istituto Oncologico Veneto Ircss Recruiting Padova 35128 Italy Details
Policlinico Gemelli Recruiting Roma 00168 Italy Details
Local Institution Recruiting Nagoya-shi Aichi 4648681 Japan Details
Local Institution - 0112 Recruiting Chiba-shi Chiba 260-8717 Japan Details
Local Institution - 0107 Recruiting Kashiwa-shi Chiba 2778577 Japan Details
Local Institution - 0132 Recruiting Matsuyama Ehime 791-0280 Japan Details
Local Institution - 0116 Recruiting Fukuoka-shi Fukuoka 8111395 Japan Details
Local Institution - 0174 Recruiting Sapporo-shi Hokkaido 0608648 Japan Details
Local Institution - 0128 Recruiting Kanazawa-city Ishikawa 9208641 Japan Details
Local Institution - 0111 Recruiting Kawasaki-shi Kanagawa 2168511 Japan Details
Local Institution Recruiting Yokohama Kanagawa 2418515 Japan Details
Local Institution - 0133 Recruiting Kumamoto-shi Kumamoto 8608556 Japan Details
Local Institution Recruiting Osaki Miyagi 9896183 Japan Details
Local Institution Recruiting Kurashiki Okayama 7108602 Japan Details
Local Institution - 0115 Recruiting Suita-shi Osaka 5650871 Japan Details
Local Institution Recruiting Hidaka Saitama 350-1298 Japan Details
Local Institution Recruiting Kitaadachigun Saitama 362-0806 Japan Details
Local Institution - 0108 Recruiting Sunto-gun Shizuoka 4118777 Japan Details
Local Institution - 0118 Recruiting Chuo-ku Tokyo 1040045 Japan Details
Local Institution - 0113 Recruiting Koto-ku Tokyo 135-8550 Japan Details
Local Institution - 0129 Recruiting Minato-ku Tokyo 1058470 Japan Details
Local Institution - 0114 Recruiting Osaka 540-0006 Japan Details
Local Institution - 0052 Recruiting Amsterdam 1066 CX Netherlands Details
Local Institution Recruiting Amsterdam 1105 AZ Netherlands Details
Local Institution - 0050 Recruiting Utrecht 3584 CX Netherlands Details
Local Institution - 0033 Recruiting Bergen 5021 Norway Details
Local Institution - 0034 Completed Lorenskog 1478 Norway Details
Local Institution - 0035 Recruiting Oslo 0450 Norway Details
Pan American Center for Oncology Trials, LLC Recruiting Rio Piedras 00935 Puerto Rico Details
Local Institution - 0076 Recruiting Cluj-Napoca Cluj 400015 Romania Details
Local Institution - 0168 Completed Brasov 002200 Romania Details
Institutul Clinic Fundeni Recruiting Bucharest 022328 Romania Details
Local Institution Withdrawn Constanta 900591 Romania Details
Local Institution - 0081 Recruiting Craiova 200347 Romania Details
Local Institution - 0205 Recruiting Iași 700483 Romania Details
County Emergency Hospital Suceava Recruiting Suceava 720237 Romania Details
Local Institution - 0173 Recruiting A Coruna 15006 Spain Details
Local Institution - 0056 Recruiting Badalona-barcelona 08916 Spain Details
Local Institution - 0006 Recruiting Barcelona 08035 Spain Details
Local Institution Withdrawn Madrid 28034 Spain Details
Local Institution - 0005 Recruiting Madrid 28041 Spain Details
Local Institution - 0172 Recruiting Malaga 29010 Spain Details
Local Institution - 0063 Recruiting Sevilla 41013 Spain Details
Local Institution - 0171 Recruiting Valencia 46014 Spain Details
Local Institution - 0092 Recruiting Adana 01060 Turkey Details
Local Institution - 0101 Recruiting Istanbul 34300 Turkey Details
Local Institution - 0127 Recruiting London Greater London EC1A 7BE United Kingdom Details
Local Institution Withdrawn London Greater London SE1 9RY United Kingdom Details
Local Institution Withdrawn Leeds Yorkshire LS9 7TF United Kingdom Details
Local Institution - 0049 Recruiting Oxford OX3 7LE United Kingdom Details
*Shaded cells indicate that there was no data available from clincialtrials.gov for the field