Clinical Trial Detail


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NCT ID NCT04122625
Title Study to Assess Safety and Efficacy of the Second Mitochondrial-derived Activator of Caspases (SMAC) Mimetic Debio 1143 (SMARTPLUS-106)
Recruitment Completed
Gender both
Phase Phase Ib/II
Variant Requirements No
Sponsors Debiopharm International SA

endometrial cancer

lung small cell carcinoma

head and neck squamous cell carcinoma

peritoneum cancer

gastrointestinal system cancer

ovary epithelial cancer

Advanced Solid Tumor

cervical cancer


Nivolumab + Xevinapant

Age Groups: adult | senior
Covered Countries USA | FRA | ESP

Facility Status City State Zip Country Details
University of Florida Gainesville Florida 32611 United States Details
H. Lee Moffitt Cancer Center and Research Institute Tampa Florida 33612-9497 United States Details
Rush University Medical Center Chicago Illinois 60612 United States Details
Beth Israel Deaconess Medical Center Boston Massachusetts 02215 United States Details
Dana-Farber/Partners Cancer Care Boston Massachusetts 02215 United States Details
Washington University Saint Louis Missouri 63110 United States Details
Montefiore Medical Center PRIME Bronx New York 10461 United States Details
UC Health, LLC. Cincinnati Ohio 45229 United States Details
St. Luke's University Health Network Bethlehem Pennsylvania 18015 United States Details
Methodist Hospital, Houston Methodist Cancer Center Houston Texas 77030 United States Details
Georgetown University - Lombardi Comprehensive Cancer Center Northwest Washington 20007 United States Details
Centre Leon Berard Lyon 69008 France Details
Institut Universitaire du Cancer de Toulouse Oncopole Toulouse 31100 France Details
Institut Gustave Roussy Villejuif 94800 France Details
Hospital Vall d'Hebron Barcelona 08035 Spain Details
START Madrid, Fundacion Jimenez Diaz Madrid 28040 Spain Details
START Madrid, H.U. Sanchinarro Madrid 28050 Spain Details
*Shaded cells indicate that there was no data available from for the field