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NCT ID NCT04246177
Title Safety and Efficacy of Lenvatinib (E7080/MK-7902) With Pembrolizumab (MK-3475) in Combination With Transarterial Chemoembolization (TACE) in Participants With Incurable/Non-metastatic Hepatocellular Carcinoma (MK-7902-012/E7080-G000-318/LEAP-012)
Recruitment Recruiting
Gender both
Phase Phase III
Variant Requirements No
Sponsors Merck Sharp & Dohme Corp.
Indications

hepatocellular carcinoma

Therapies

Lenvatinib + Pembrolizumab

Age Groups: adult | senior
Covered Countries USA | ITA | FRA | ESP | DEU

Facility Status City State Zip Country Details
Arizona Oncology Associates PC- HOPE ( Site 0770) Completed Tucson Arizona 85711 United States Details
Scripps Clinic Torrey Pines ( Site 0714) Completed La Jolla California 92037 United States Details
USC Norris Comprehensive Cancer Center ( Site 0717) Recruiting Los Angeles California 90033 United States Details
UCLA Hematology/Oncology - Santa Monica ( Site 0720) Recruiting Los Angeles California 90404 United States Details
UC Irvine Health ( Site 0718) Recruiting Orange California 92868 United States Details
Yale Cancer Center ( Site 0724) Recruiting New Haven Connecticut 06510 United States Details
Tampa General Hospital ( Site 0764) Recruiting Tampa Florida 33606 United States Details
Mountain States Tumor Institute ( Site 0773) Recruiting Boise Idaho 83712 United States Details
University of Iowa Hospital and Clinics ( Site 0729) Recruiting Iowa City Iowa 52242 United States Details
University of Kansas Cancer Center ( Site 0731) Recruiting Westwood Kansas 66205 United States Details
University of Louisville ( Site 0757) Recruiting Louisville Kentucky 40202 United States Details
Tulane Medical Center ( Site 0787) Recruiting New Orleans Louisiana 70112 United States Details
University Medical Center New Orleans ( Site 0733) Recruiting New Orleans Louisiana 70112 United States Details
Henry Ford Hospital-GI/Hepatology Research ( Site 0735) Recruiting Detroit Michigan 48202 United States Details
Saint Louis University ( Site 0769) Recruiting Saint Louis Missouri 63110 United States Details
University of New Mexico Comprehensive Cancer Center ( Site 0805) Recruiting Albuquerque New Mexico 87131 United States Details
Monter Cancer Center ( Site 0780) Recruiting Lake Success New York 11042 United States Details
Icahn School of Medicine at Mount Sinai ( Site 0744) Recruiting New York New York 10029 United States Details
Wake Forest Baptist Health ( Site 0741) Completed Winston-Salem North Carolina 27157 United States Details
University of Cincinnati Medical Center ( Site 0791) Recruiting Cincinnati Ohio 45219 United States Details
The Ohio State University Wexner Medical Center ( Site 0759) Recruiting Columbus Ohio 43210 United States Details
ProMedica Flower Hospital ( Site 0796) Recruiting Sylvania Ohio 43560 United States Details
Stephenson Cancer Center ( Site 0745) Completed Oklahoma City Oklahoma 73104 United States Details
OHSU Center for Health & Healing ( Site 0746) Recruiting Portland Oregon 97239 United States Details
Penn State Hershey Medical Center ( Site 0766) Recruiting Hershey Pennsylvania 17033-0850 United States Details
Houston Methodist Research Institute ( Site 0784) Recruiting Houston Texas 77030 United States Details
Edwards Comprehensive Cancer Center ( Site 0786) Recruiting Huntington West Virginia 25701 United States Details
St George Hospital ( Site 0005) Completed Kogarah New South Wales 2217 Australia Details
Westmead Hospital-Gastroenterology & Hepatology ( Site 0009) Recruiting Westmead New South Wales 2145 Australia Details
Princess Alexandra Hospital ( Site 0006) Recruiting Brisbane Queensland 4102 Australia Details
Austin Health ( Site 0008) Recruiting Heidelberg Victoria 3084 Australia Details
Alfred Health ( Site 0004) Recruiting Melbourne Victoria 3004 Australia Details
Royal Perth Hospital ( Site 0002) Completed Perth Western Australia 6000 Australia Details
Liga Norte Riograndense Contra o Câncer-Centro de Pesquisa Clínica ( Site 0057) Recruiting Natal Rio Grande Do Norte 59075-740 Brazil Details
Hospital Nossa Senhora da Conceição-Centro Integrado de Pesquisa em Oncologia ( Site 0056) Recruiting Porto Alegre Rio Grande Do Sul 91350-200 Brazil Details
Clinica de Oncologia Reichow ( Site 0052) Recruiting Blumenau Santa Catarina 89010-340 Brazil Details
Fundacao Dr Amaral Carvalho ( Site 0050) Recruiting JAU Sao Paulo 17210-120 Brazil Details
Hospital de Base de Sao Jose de Rio Preto ( Site 0043) Recruiting Sao Jose do Rio Preto Sao Paulo 15090-000 Brazil Details
BP - A Beneficencia Portuguesa de São Paulo ( Site 0046) Recruiting São Paulo Sao Paulo 01323-001 Brazil Details
A.C. Camargo Cancer Center ( Site 0054) Recruiting Sao Paulo 01509-900 Brazil Details
Centro Investigación del Cáncer James Lind ( Site 0064) Recruiting Temuco Araucania 4800827 Chile Details
Centro de Cancer Nuestra Senora de la Esperanza ( Site 0065) Recruiting Santiago Region M. De Santiago 8330024 Chile Details
Bradfordhill ( Site 0066) Recruiting Santiago Region M. De Santiago 8420383 Chile Details
Anhui Provincial Hospital ( Site 0092) Recruiting Heifei Anhui 230001 China Details
Beijing Cancer Hospital ( Site 0099) Recruiting Beijing Beijing 100142 China Details
Beijing Cancer Hospital ( Site 0105) Recruiting Beijing Beijing 100142 China Details
Peking Union Medical College Hospital ( Site 0087) Recruiting Beijing Beijing 100730 China Details
Chinese People s Liberation Army Army Characteristic Medical Center ( Site 0117) Recruiting Chongqing Chongqing 400042 China Details
Chongqing Three Gorges Central Hospital ( Site 0859) Recruiting Wanzhou Chongqing 404199 China Details
Mengchao Hepatobiliary Hospital of Fujian Medical University ( Site 0121) Recruiting Fuzhou Fujian 350001 China Details
Fujian Provincial Cancer Hospital ( Site 0085) Recruiting Fuzhou Fujian 350014 China Details
The First Affiliated Hospital of Fujian Medical University ( Site 0089) Recruiting Fuzhou Fujian 350014 China Details
Zhongshan Hospital Fudan University (Xiamen Branch) ( Site 0133) Recruiting Xiamen Fujian 361015 China Details
Zhujiang Hospital of Southern Medical University ( Site 0115) Recruiting Guangzhou Guangdong 510000 China Details
Guangdong Provincial People s Hospital ( Site 0100) Completed Guangzhou Guangdong 510080 China Details
Nanfang Hospital of Southern Medical University ( Site 0088) Recruiting Guangzhou Guangdong 510515 China Details
SUN YAT-SEN UNIVERSITY CANCER CENTRE-Department of Medical Imaging and Interventional Radiology ( Si Recruiting Guangzhou Guangdong 510700 China Details
Guangxi Medical University Affiliated Tumor Hospital-Hepatological surgery ( Site 0862) Recruiting Nanning Guangxi 530021 China Details
Hainan General Hospital ( Site 0112) Recruiting Haikou Hainan 570311 China Details
Harbin Medical University Cancer Hospital ( Site 0090) Recruiting Harbin Heilongjiang 150081 China Details
Henan Cancer Hospital ( Site 0114) Recruiting Zhengzhou Henan 450008 China Details
Tongji Hospital Tongji Medical,Science & Technology ( Site 0126) Recruiting Wuhan Hubei 430030 China Details
Hubei Cancer Hospital ( Site 0101) Recruiting Wuhan Hubei 430079 China Details
Hunan Provincial People's Hospital ( Site 0113) Recruiting Changsha Hunan 410005 China Details
Hunan Cancer Hospital ( Site 0096) Recruiting Changsha Hunan 410013 China Details
The First Affiliated Hospital of Soochow University ( Site 0120) Recruiting Suzhou Jiangsu 215006 China Details
Jiangxi Provincial Cancer Hospital-Cancer Hospital ( Site 0134) Recruiting Nanchang Jiangxi 330029 China Details
Xi'an International Medical Center Hospital ( Site 0860) Recruiting Xi'an Shaanxi 710126 China Details
The Third Affiliated Hospital of Naval Medical University ( Site 0123) Recruiting Shanghai Shanghai 200028 China Details
Fudan University Shanghai Cancer Center ( Site 0106) Recruiting Shanghai Shanghai 200032 China Details
Zhongshan Hospital Fudan University ( Site 0084) Recruiting Shanghai Shanghai 200032 China Details
The First Affiliated Hospital of Xi an Jiaotong University ( Site 0108) Recruiting XI An Shanxi 710048 China Details
West China Hospital of Sichuan University ( Site 0119) Recruiting Chengdu Sichuan 610041 China Details
Suining Central Hospital ( Site 0857) Recruiting Suining Sichuan 629000 China Details
Tianjin Medical University Cancer Institute & Hospital ( Site 0098) Recruiting Tianjin Tianjin 300060 China Details
The First Hospital of Kunming ( Site 0124) Recruiting Kunming Yunnan 650200 China Details
2nd Affil Hosp of Zhejiang University College of Medicine ( Site 0110) Recruiting Hangzhou Zhejiang 310009 China Details
Sir Run Run Shaw Hospital ( Site 0094) Recruiting Hangzhou Zhejiang 310018 China Details
Zhejiang Cancer Hospital ( Site 0103) Recruiting Hangzhou Zhejiang 310022 China Details
Ningbo Medical Center ( Site 0132) Recruiting Ningbo Zhejiang 315041 China Details
Hospital Pablo Tobon Uribe ( Site 0145) Recruiting Medellin Antioquia 050034 Colombia Details
Administradora Country S.A. ( Site 0137) Recruiting Bogota Distrito Capital De Bogota 110221 Colombia Details
Fundacion Cardiovascular de Colombia ( Site 0136) Recruiting Piedecuesta Santander 681017 Colombia Details
Fundacion Valle del Lili ( Site 0140) Recruiting Cali Valle Del Cauca 760032 Colombia Details
Herlev Hospital ( Site 0170) Recruiting Herlev Hovedstaden 2730 Denmark Details
Aarhus Universitets hospital ( Site 0175) Recruiting Aarhus N Midtjylland 8200 Denmark Details
Odense Universitetshospital ( Site 0160) Recruiting Odense Syddanmark 5000 Denmark Details
Hopital de la Croix-Rousse ( Site 0193) Recruiting Lyon Auvergne 69004 France Details
Hopital de la Timone ( Site 0188) Recruiting Marseille Bouches-du-Rhone 13005 France Details
CHU Bordeaux Haut-Leveque ( Site 0185) Recruiting Pessac Cedex Gironde 33604 France Details
C.H.U. de Nancy. Hopital de Brabois Adultes ( Site 0180) Recruiting Vandoeuvre les Nancy Meurthe-et-Moselle 54500 France Details
A.P.H. Paris, Hopital Henri Mondor ( Site 0179) Recruiting Creteil Val-de-Marne 94000 France Details
Hopital Paul Brousse ( Site 0182) Recruiting Villejuif Val-de-Marne 94800 France Details
Universitaetsklinikum Freiburg ( Site 0199) Completed Freiburg Baden-Wurttemberg 79106 Germany Details
Krankenhaus Nord-West GmbH ( Site 0208) Recruiting Frankfurt am Main Hessen 60488 Germany Details
Medizinische Hochschule Hannover ( Site 0200) Recruiting Hannover Niedersachsen 30625 Germany Details
Universitaetsklinikum Bonn ( Site 0203) Recruiting Bonn Nordrhein-Westfalen 53127 Germany Details
Universitaetsklinikum Halle ( Site 0213) Recruiting Halle (Saale) Sachsen-Anhalt 06120 Germany Details
Universitaetsklinikum Leipzig ( Site 0202) Recruiting Leipzig Sachsen 04103 Germany Details
Universitaetsklinikum Schleswig-Holstein-Campus Lubeck ( Site 0215) Recruiting Luebeck Schleswig-Holstein 23538 Germany Details
Charite - Universitaetsmedizin ( Site 0204) Recruiting Berlin 13353 Germany Details
Universitaetsklinikum Hamburg-Eppendorf ( Site 0207) Recruiting Hamburg 20246 Germany Details
Prince of Wales Hospital ( Site 0242) Recruiting Shatin 000 Hong Kong Details
Somogy Megyei Kaposi Mór Oktató Kórház-Oncology center ( Site 0267) Recruiting Kaposvár Somogy 7400 Hungary Details
Zala Megyei Szent Rafael Korhaz ( Site 0265) Recruiting Zalaegerszeg Zala 8900 Hungary Details
Semmelweis University ( Site 0264) Recruiting Budapest 1085 Hungary Details
St Vincents University Hospital ( Site 0690) Recruiting Dublin D04 YN63 Ireland Details
Emek Medical Center ( Site 0307) Recruiting Afula 18341 Israel Details
Rambam Health Care Campus-Oncology Division ( Site 0305) Recruiting Haifa 3109601 Israel Details
Hadassah Ein Karem Jerusalem ( Site 0303) Recruiting Jerusaelm 9112001 Israel Details
Rabin Medical Center ( Site 0304) Completed Petah Tikva 4941492 Israel Details
Sourasky Medical Center ( Site 0306) Recruiting Tel Aviv 6423906 Israel Details
Ospedale del Mare ( Site 0327) Recruiting Napoli Campania 80147 Italy Details
ASST Grande Ospedale Metropolitano Niguarda-Oncologia Falck ( Site 0331) Recruiting Milan Milano 20162 Italy Details
Ospedale Mauriziano-SCDU ONCOLOGIA MEDICA ( Site 0333) Recruiting Torino Piemonte 10128 Italy Details
AOU Policlinico G. Martino ( Site 0324) Recruiting Messina Sicilia 98124 Italy Details
Azienda Ospedaliera Spedali Civili di Brescia-Oncology ( Site 0334) Recruiting Brescia 25123 Italy Details
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico ( Site 0325) Recruiting Milano 20122 Italy Details
Az Osp di Rilievo Nazionale A. Cardarelli ( Site 0329) Recruiting Napoli 80131 Italy Details
Azienda USL della Romagna-Dipartimento di Oncologia ed Ematologia ( Site 0332) Recruiting Ravenna 48121 Italy Details
Policlinico Universitario -Agostino Gemelli ( Site 0328) Recruiting Roma 00168 Italy Details
National Cancer Center Hospital East ( Site 0347) Recruiting Kashiwa Chiba 2778577 Japan Details
Ehime University Hospital ( Site 0368) Recruiting Toon Ehime 7910295 Japan Details
Kurume University Hospital ( Site 0362) Recruiting Kurume Fukuoka 830-0011 Japan Details
Hokkaido P.W.F.A.C Sapporo-Kosei General Hospital ( Site 0345) Recruiting Sapporo Hokkaido 060-0033 Japan Details
Kanazawa University Hospital ( Site 0354) Recruiting Kanazawa Ishikawa 920-8641 Japan Details
Kagawa Prefectural Central Hospital ( Site 0364) Recruiting Takamatsu Kagawa 760-8557 Japan Details
Toranomon Hospital Kajigaya ( Site 0369) Recruiting Kawasaki Kanagawa 213-8587 Japan Details
Yokohama City University Medical Center ( Site 0351) Recruiting Yokohama Kanagawa 232-0024 Japan Details
Kanagawa Cancer Center ( Site 0352) Recruiting Yokohama Kanagawa 241-8515 Japan Details
Nara Medical University Hospital ( Site 0359) Recruiting Kashihara Nara 634-8522 Japan Details
Kindai University Hospital ( Site 0358) Recruiting Osakasayama Osaka 5898511 Japan Details
Saitama Medical University Hospital ( Site 0370) Recruiting Iruma-gun Saitama 350-0495 Japan Details
Shizuoka Cancer Center Hospital and Research Institute ( Site 0365) Recruiting Sunto-gun Shizuoka 411-8777 Japan Details
Jichi Medical University Hospital ( Site 0353) Recruiting Shimotsuke Tochigi 329-0498 Japan Details
Chiba University Hospital ( Site 0346) Recruiting Chiba 260-8677 Japan Details
National Hospital Organization Kyushu Medical Center ( Site 0361) Recruiting Fukuoka 810-8563 Japan Details
Hiroshima University Hospital ( Site 0360) Recruiting Hiroshima 7348551 Japan Details
Kumamoto University ( Site 0372) Recruiting Kumamoto 860-8556 Japan Details
University Hospital, Kyoto Prefectural University of Medicine ( Site 0367) Recruiting Kyoto 602-8566 Japan Details
Osaka International Cancer Institute ( Site 0357) Recruiting Osaka 541-8567 Japan Details
Japanese Red Cross Osaka Hospital ( Site 0356) Recruiting Osaka 543-8555 Japan Details
Saga-Ken Medical Centre Koseikan ( Site 0363) Recruiting Saga 840-8571 Japan Details
Toranomon Hospital ( Site 0349) Recruiting Tokyo 105-8470 Japan Details
Juntendo University Hospital ( Site 0371) Recruiting Tokyo 113-0033 Japan Details
The University of Tokyo Hospital ( Site 0348) Recruiting Tokyo 113-8655 Japan Details
Chonnam National University Hwasun Hospital ( Site 0572) Recruiting Hwasun Jeonranamdo 58128 Korea, Republic of Details
Seoul National University Bundang Hospital ( Site 0570) Completed Seongnam-si Kyonggi-do 13620 Korea, Republic of Details
Pusan National University Hospital ( Site 0568) Recruiting Busan Pusan-Kwangyokshi 49241 Korea, Republic of Details
Kyungpook National University Hospital ( Site 0569) Recruiting Daegu Taegu-Kwangyokshi 41944 Korea, Republic of Details
Seoul National University Hospital ( Site 0567) Recruiting Seoul 03080 Korea, Republic of Details
Severance Hospital Yonsei University Health System ( Site 0564) Recruiting Seoul 03722 Korea, Republic of Details
Asan Medical Center ( Site 0565) Recruiting Seoul 05505 Korea, Republic of Details
Samsung Medical Center ( Site 0566) Recruiting Seoul 06351 Korea, Republic of Details
The Catholic University of Korea St. Mary s Hospital ( Site 0571) Recruiting Seoul 06591 Korea, Republic of Details
Korea University Guro Hospital ( Site 0573) Recruiting Seoul 08308 Korea, Republic of Details
Maastricht University Medical Centre ( Site 0440) Recruiting Maastricht Limburg 6229 HX Netherlands Details
AMC ( Site 0438) Recruiting Amsterdam Noord-Holland 1105 AZ Netherlands Details
Leids Universitair Medisch Centrum-Medical Oncology ( Site 0442) Recruiting Leiden Zuid-Holland 2333 ZA Netherlands Details
Erasmus University Medical Center ( Site 0439) Recruiting Rotterdam Zuid-Holland 3015GD Netherlands Details
Universitair Medisch Centrum Utrecht-Medical Oncology ( Site 0441) Recruiting Utrecht 3584 CX Netherlands Details
Auckland City Hospital ( Site 0459) Recruiting Auckland 1023 New Zealand Details
Oslo Universitetssykehus Ullevål ( Site 0500) Recruiting Oslo 0450 Norway Details
Centro Hospitalar e Universitario de Coimbra ( Site 0502) Recruiting Coimbra 3000-075 Portugal Details
Centro Hospitalar de Lisboa Central, EPE - Hosp St. Ant dos Capuchos ( Site 0505) Recruiting Lisboa 1169-050 Portugal Details
Centro Hospitalar do Porto, E.P.E. - Hospital Geral de Sto. Antonio ( Site 0504) Recruiting Porto 4099-001 Portugal Details
Inst. Portugues de Oncologia de Porto Francisco Gentil EPE ( Site 0503) Recruiting Porto 4200-072 Portugal Details
Centro Hospitalar de Sao Joao. EPE - Hospital de Sao Joao ( Site 0501) Recruiting Porto 4200-319 Portugal Details
Ad-Vance Medical Research LLC ( Site 0527) Recruiting Ponce 00717 Puerto Rico Details
Puerto Rico Medical Research Center LLC ( Site 0523) Recruiting San Juan 00918 Puerto Rico Details
VA Caribbean Healthcare System ( Site 0524) Recruiting San Juan 00921-3201 Puerto Rico Details
FDI Clinical Research ( Site 0522) Recruiting San Juan 00927 Puerto Rico Details
Hospital Universitario Puerta de Hierro ( Site 0596) Recruiting Majadahonda Madrid 28222 Spain Details
Hospital General Universitario de Valencia ( Site 0595) Recruiting Valencia Valenciana, Comunitat 46014 Spain Details
Hospital General Universitario Gregorio Maranon ( Site 0598) Recruiting Madrid 28007 Spain Details
Hospital Ramon y Cajal ( Site 0593) Recruiting Madrid 28034 Spain Details
Hospital Clinico San Carlos ( Site 0597) Recruiting Madrid 28040 Spain Details
Hospital Virgen del Rocio ( Site 0591) Recruiting Sevilla 41013 Spain Details
Chang Gung Medical Foundation. Kaohsiung Branch ( Site 0609) Recruiting Kaohsiung City Kaohsiung 833 Taiwan Details
Kaohsiung Medical University Hospital ( Site 0611) Recruiting Kaohsiung 807 Taiwan Details
China Medical University Hospital-Surgical Department ( Site 0610) Recruiting Taichung 40447 Taiwan Details
Taichung Veterans General Hospital ( Site 0613) Recruiting Taichung 407 Taiwan Details
National Cheng Kung University Hospital ( Site 0608) Recruiting Tainan 70457 Taiwan Details
National Taiwan University Hospital ( Site 0606) Recruiting Taipei 10002 Taiwan Details
Taipei Veterans General Hospital-Division of Gastroenterology & Hepatology, Department of Medicine ( Recruiting Taipei 112201 Taiwan Details
Chang Gung Medical Foundation. Linkou ( Site 0607) Recruiting Taoyuan 333 Taiwan Details
Chulalongkorn University ( Site 0627) Recruiting Bangkok Krung Thep Maha Nakhon 10330 Thailand Details
Ramathibodi Hospital, Mahidol University ( Site 0628) Recruiting Bangkok Krung Thep Maha Nakhon 10400 Thailand Details
Faculty of Medicine Siriraj Hospital ( Site 0629) Recruiting Bangkok Krung Thep Maha Nakhon 10700 Thailand Details
Hacettepe University Medical Faculty ( Site 0653) Recruiting Ankara 06230 Turkey Details
Ankara City Hospital-Medical Oncology ( Site 0661) Recruiting Ankara 06800 Turkey Details
Trakya University Medical Faculty Balkan Oncology Hospital ( Site 0648) Recruiting Edirne 22030 Turkey Details
Bezmialem Vakf Üniversitesi-Oncology ( Site 0660) Recruiting Istanbul 34093 Turkey Details
Ege University Medical Faculty Tulay Aktas Oncology Hospital ( Site 0654) Recruiting Izmir 35100 Turkey Details
I.E.U. Medical Point Hastanesi ( Site 0649) Recruiting Izmir 35575 Turkey Details
Konya Necmettin Erbakan University Medical Faculty ( Site 0652) Recruiting Konya 42080 Turkey Details
Inonu Universitesi Medical Fakultesi ( Site 0650) Completed Malatya 44280 Turkey Details
Grigoriev Institute for medical Radiology NAMS of Ukraine ( Site 0673) Suspended Kharkiv Kharkivska Oblast 61024 Ukraine Details
Communal non profit enterprise Regional Clinical Oncology Center ( Site 0669) Suspended Kharkiv Kharkivska Oblast 61070 Ukraine Details
Shalimov s NI of Surgery and Transplantation ( Site 0671) Suspended Kyiv Kyivska Oblast 03126 Ukraine Details
Barts Health NHS Trust ( Site 0692) Recruiting London London, City Of EC1A 7BE United Kingdom Details
Royal Marsden NHS Foundation Trust ( Site 0694) Recruiting London London, City Of SW3 6JJ United Kingdom Details
Royal Marsden NHS Trust ( Site 0693) Recruiting Sutton London, City Of SM25PT United Kingdom Details
*Shaded cells indicate that there was no data available from clincialtrials.gov for the field