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| NCT ID | NCT04546399 |
| Title | A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL) |
| Recruitment | Recruiting |
| Gender | both |
| Phase | Phase II |
| Variant Requirements | No |
| Sponsors | National Cancer Institute (NCI) |
| Indications | |
| Therapies |
Blinatumomab + Methotrexate + Nivolumab Dexamethasone + Pegaspargase + Vincristine Sulfate Blinatumomab + Dexamethasone + Methotrexate Blinatumomab + Cytarabine + Dexamethasone + Hydrocortisone Sodium Succinate + Methotrexate Blinatumomab + Dexamethasone + Methotrexate + Nivolumab Dexamethasone + Mercaptopurine + Methotrexate + Vincristine Sulfate |
| Age Groups: | adult | child |
| Covered Countries | USA | CAN |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Children's Hospital of Alabama | Recruiting | Birmingham | Alabama | 35233 | United States | Details |
| USA Health Strada Patient Care Center | Recruiting | Mobile | Alabama | 36604 | United States | Details |
| Providence Alaska Medical Center | Recruiting | Anchorage | Alaska | 99508 | United States | Details |
| Kingman Regional Medical Center | Suspended | Kingman | Arizona | 86401 | United States | Details |
| Banner Children's at Desert | Recruiting | Mesa | Arizona | 85202 | United States | Details |
| Banner University Medical Center - Tucson | Recruiting | Tucson | Arizona | 85719 | United States | Details |
| Arkansas Children's Hospital | Recruiting | Little Rock | Arkansas | 72202-3591 | United States | Details |
| Kaiser Permanente-Anaheim | Suspended | Anaheim | California | 92806 | United States | Details |
| PCR Oncology | Suspended | Arroyo Grande | California | 93420 | United States | Details |
| Kaiser Permanente-Bellflower | Suspended | Bellflower | California | 90706 | United States | Details |
| Kaiser Permanente Downey Medical Center | Recruiting | Downey | California | 90242 | United States | Details |
| City of Hope Comprehensive Cancer Center | Recruiting | Duarte | California | 91010 | United States | Details |
| Kaiser Permanente-Fontana | Suspended | Fontana | California | 92335 | United States | Details |
| Loma Linda University Medical Center | Recruiting | Loma Linda | California | 92354 | United States | Details |
| Children's Hospital Los Angeles | Recruiting | Los Angeles | California | 90027 | United States | Details |
| Kaiser Permanente Los Angeles Medical Center | Suspended | Los Angeles | California | 90027 | United States | Details |
| Cedars Sinai Medical Center | Suspended | Los Angeles | California | 90048 | United States | Details |
| Mattel Children's Hospital UCLA | Recruiting | Los Angeles | California | 90095 | United States | Details |
| Valley Children's Hospital | Recruiting | Madera | California | 93636 | United States | Details |
| Kaiser Permanente-Oakland | Recruiting | Oakland | California | 94611 | United States | Details |
| Children's Hospital of Orange County | Recruiting | Orange | California | 92868 | United States | Details |
| Lucile Packard Children's Hospital Stanford University | Recruiting | Palo Alto | California | 94304 | United States | Details |
| Sutter Medical Center Sacramento | Recruiting | Sacramento | California | 95816 | United States | Details |
| University of California Davis Comprehensive Cancer Center | Recruiting | Sacramento | California | 95817 | United States | Details |
| Kaiser Permanente-San Diego Zion | Suspended | San Diego | California | 92120 | United States | Details |
| Rady Children's Hospital - San Diego | Recruiting | San Diego | California | 92123 | United States | Details |
| UCSF Medical Center-Mission Bay | Recruiting | San Francisco | California | 94158 | United States | Details |
| Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center | Recruiting | Torrance | California | 90502 | United States | Details |
| Children's Hospital Colorado | Recruiting | Aurora | Colorado | 80045 | United States | Details |
| Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center | Recruiting | Denver | Colorado | 80218 | United States | Details |
| Connecticut Children's Medical Center | Recruiting | Hartford | Connecticut | 06106 | United States | Details |
| Alfred I duPont Hospital for Children | Recruiting | Wilmington | Delaware | 19803 | United States | Details |
| Children's National Medical Center | Recruiting | Washington | District of Columbia | 20010 | United States | Details |
| Golisano Children's Hospital of Southwest Florida | Recruiting | Fort Myers | Florida | 33908 | United States | Details |
| University of Florida Health Science Center - Gainesville | Recruiting | Gainesville | Florida | 32610 | United States | Details |
| Memorial Regional Hospital/Joe DiMaggio Children's Hospital | Recruiting | Hollywood | Florida | 33021 | United States | Details |
| Nemours Children's Clinic-Jacksonville | Recruiting | Jacksonville | Florida | 32207 | United States | Details |
| AdventHealth Orlando | Recruiting | Orlando | Florida | 32803 | United States | Details |
| Arnold Palmer Hospital for Children | Recruiting | Orlando | Florida | 32806 | United States | Details |
| Nemours Children's Hospital | Recruiting | Orlando | Florida | 32827 | United States | Details |
| Sacred Heart Hospital | Recruiting | Pensacola | Florida | 32504 | United States | Details |
| Johns Hopkins All Children's Hospital | Suspended | Saint Petersburg | Florida | 33701 | United States | Details |
| Tampa General Hospital | Recruiting | Tampa | Florida | 33606 | United States | Details |
| Saint Joseph's Hospital/Children's Hospital-Tampa | Recruiting | Tampa | Florida | 33607 | United States | Details |
| Saint Mary's Hospital | Recruiting | West Palm Beach | Florida | 33407 | United States | Details |
| Children's Healthcare of Atlanta - Egleston | Recruiting | Atlanta | Georgia | 30322 | United States | Details |
| Memorial Health University Medical Center | Recruiting | Savannah | Georgia | 31404 | United States | Details |
| Kapiolani Medical Center for Women and Children | Recruiting | Honolulu | Hawaii | 96826 | United States | Details |
| Saint Luke's Cancer Institute - Boise | Recruiting | Boise | Idaho | 83712 | United States | Details |
| Lurie Children's Hospital-Chicago | Recruiting | Chicago | Illinois | 60611 | United States | Details |
| University of Illinois | Recruiting | Chicago | Illinois | 60612 | United States | Details |
| University of Chicago Comprehensive Cancer Center | Recruiting | Chicago | Illinois | 60637 | United States | Details |
| Loyola University Medical Center | Recruiting | Maywood | Illinois | 60153 | United States | Details |
| Saint Jude Midwest Affiliate | Recruiting | Peoria | Illinois | 61637 | United States | Details |
| Riley Hospital for Children | Recruiting | Indianapolis | Indiana | 46202 | United States | Details |
| Blank Children's Hospital | Recruiting | Des Moines | Iowa | 50309 | United States | Details |
| University of Iowa/Holden Comprehensive Cancer Center | Recruiting | Iowa City | Iowa | 52242 | United States | Details |
| University of Kentucky/Markey Cancer Center | Recruiting | Lexington | Kentucky | 40536 | United States | Details |
| Ochsner Medical Center Jefferson | Recruiting | New Orleans | Louisiana | 70121 | United States | Details |
| Maine Children's Cancer Program | Recruiting | Scarborough | Maine | 04074 | United States | Details |
| Sinai Hospital of Baltimore | Recruiting | Baltimore | Maryland | 21215 | United States | Details |
| Johns Hopkins University/Sidney Kimmel Cancer Center | Recruiting | Baltimore | Maryland | 21287 | United States | Details |
| Walter Reed National Military Medical Center | Active, not recruiting | Bethesda | Maryland | 20889-5600 | United States | Details |
| Tufts Children's Hospital | Active, not recruiting | Boston | Massachusetts | 02111 | United States | Details |
| C S Mott Children's Hospital | Recruiting | Ann Arbor | Michigan | 48109 | United States | Details |
| Bronson Battle Creek | Suspended | Battle Creek | Michigan | 49017 | United States | Details |
| Beaumont Hospital - Dearborn | Suspended | Dearborn | Michigan | 48124 | United States | Details |
| Michigan State University Clinical Center | Recruiting | East Lansing | Michigan | 48824-7016 | United States | Details |
| Helen DeVos Children's Hospital at Spectrum Health | Recruiting | Grand Rapids | Michigan | 49503 | United States | Details |
| Mercy Health Saint Mary's | Suspended | Grand Rapids | Michigan | 49503 | United States | Details |
| Spectrum Health at Butterworth Campus | Suspended | Grand Rapids | Michigan | 49503 | United States | Details |
| Bronson Methodist Hospital | Suspended | Kalamazoo | Michigan | 49007 | United States | Details |
| West Michigan Cancer Center | Suspended | Kalamazoo | Michigan | 49007 | United States | Details |
| Borgess Medical Center | Suspended | Kalamazoo | Michigan | 49048 | United States | Details |
| Mercy Health Mercy Campus | Suspended | Muskegon | Michigan | 49444 | United States | Details |
| Lakeland Hospital Niles | Suspended | Niles | Michigan | 49120 | United States | Details |
| Cancer and Hematology Centers of Western Michigan - Norton Shores | Suspended | Norton Shores | Michigan | 49444 | United States | Details |
| Spectrum Health Reed City Hospital | Suspended | Reed City | Michigan | 49677 | United States | Details |
| Beaumont Children's Hospital-Royal Oak | Recruiting | Royal Oak | Michigan | 48073 | United States | Details |
| William Beaumont Hospital-Royal Oak | Suspended | Royal Oak | Michigan | 48073 | United States | Details |
| Lakeland Medical Center Saint Joseph | Suspended | Saint Joseph | Michigan | 49085 | United States | Details |
| Marie Yeager Cancer Center | Suspended | Saint Joseph | Michigan | 49085 | United States | Details |
| Munson Medical Center | Suspended | Traverse City | Michigan | 49684 | United States | Details |
| William Beaumont Hospital - Troy | Suspended | Troy | Michigan | 48085 | United States | Details |
| Metro Health Hospital | Suspended | Wyoming | Michigan | 49519 | United States | Details |
| Children's Hospitals and Clinics of Minnesota - Minneapolis | Recruiting | Minneapolis | Minnesota | 55404 | United States | Details |
| University of Minnesota/Masonic Cancer Center | Recruiting | Minneapolis | Minnesota | 55455 | United States | Details |
| University of Mississippi Medical Center | Recruiting | Jackson | Mississippi | 39216 | United States | Details |
| Children's Mercy Hospitals and Clinics | Recruiting | Kansas City | Missouri | 64108 | United States | Details |
| Cardinal Glennon Children's Medical Center | Recruiting | Saint Louis | Missouri | 63104 | United States | Details |
| Washington University School of Medicine | Recruiting | Saint Louis | Missouri | 63110 | United States | Details |
| Mercy Hospital Saint Louis | Recruiting | Saint Louis | Missouri | 63141 | United States | Details |
| Children's Hospital and Medical Center of Omaha | Recruiting | Omaha | Nebraska | 68114 | United States | Details |
| University of Nebraska Medical Center | Recruiting | Omaha | Nebraska | 68198 | United States | Details |
| Carson Tahoe Regional Medical Center | Suspended | Carson City | Nevada | 89703 | United States | Details |
| Comprehensive Cancer Centers of Nevada - Henderson | Suspended | Henderson | Nevada | 89052 | United States | Details |
| Comprehensive Cancer Centers of Nevada-Horizon Ridge | Suspended | Henderson | Nevada | 89052 | United States | Details |
| Las Vegas Cancer Center-Henderson | Suspended | Henderson | Nevada | 89052 | United States | Details |
| OptumCare Cancer Care at Seven Hills | Suspended | Henderson | Nevada | 89052 | United States | Details |
| Comprehensive Cancer Centers of Nevada-Southeast Henderson | Suspended | Henderson | Nevada | 89074 | United States | Details |
| OptumCare Cancer Care at Charleston | Suspended | Las Vegas | Nevada | 89102 | United States | Details |
| Hope Cancer Care of Nevada | Suspended | Las Vegas | Nevada | 89103 | United States | Details |
| Sunrise Hospital and Medical Center | Suspended | Las Vegas | Nevada | 89109 | United States | Details |
| Ann M Wierman MD LTD | Suspended | Las Vegas | Nevada | 89128 | United States | Details |
| Comprehensive Cancer Centers of Nevada - Northwest | Suspended | Las Vegas | Nevada | 89128 | United States | Details |
| OptumCare Cancer Care at MountainView | Suspended | Las Vegas | Nevada | 89128 | United States | Details |
| Alliance for Childhood Diseases/Cure 4 the Kids Foundation | Recruiting | Las Vegas | Nevada | 89135 | United States | Details |
| Comprehensive Cancer Centers of Nevada - Town Center | Suspended | Las Vegas | Nevada | 89144 | United States | Details |
| Comprehensive Cancer Centers of Nevada-Summerlin | Suspended | Las Vegas | Nevada | 89144 | United States | Details |
| Summerlin Hospital Medical Center | Recruiting | Las Vegas | Nevada | 89144 | United States | Details |
| Las Vegas Cancer Center-Medical Center | Suspended | Las Vegas | Nevada | 89148-2405 | United States | Details |
| Comprehensive Cancer Centers of Nevada | Suspended | Las Vegas | Nevada | 89148 | United States | Details |
| OptumCare Cancer Care at Fort Apache | Suspended | Las Vegas | Nevada | 89148 | United States | Details |
| Comprehensive Cancer Centers of Nevada - Central Valley | Suspended | Las Vegas | Nevada | 89169 | United States | Details |
| Hope Cancer Care of Nevada-Pahrump | Suspended | Pahrump | Nevada | 89048 | United States | Details |
| Renown Regional Medical Center | Recruiting | Reno | Nevada | 89502 | United States | Details |
| Saint Mary's Regional Medical Center | Suspended | Reno | Nevada | 89503 | United States | Details |
| Cancer Care Specialists - Reno | Suspended | Reno | Nevada | 89511 | United States | Details |
| Dartmouth Hitchcock Medical Center | Recruiting | Lebanon | New Hampshire | 03756 | United States | Details |
| Hackensack University Medical Center | Recruiting | Hackensack | New Jersey | 07601 | United States | Details |
| Morristown Medical Center | Recruiting | Morristown | New Jersey | 07960 | United States | Details |
| Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital | Recruiting | New Brunswick | New Jersey | 08903 | United States | Details |
| Rutgers Cancer Institute of New Jersey | Recruiting | New Brunswick | New Jersey | 08903 | United States | Details |
| Newark Beth Israel Medical Center | Suspended | Newark | New Jersey | 07112 | United States | Details |
| Saint Joseph's Regional Medical Center | Recruiting | Paterson | New Jersey | 07503 | United States | Details |
| Albany Medical Center | Recruiting | Albany | New York | 12208 | United States | Details |
| Montefiore Medical Center - Moses Campus | Recruiting | Bronx | New York | 10467 | United States | Details |
| Maimonides Medical Center | Recruiting | Brooklyn | New York | 11219 | United States | Details |
| NYU Winthrop Hospital | Recruiting | Mineola | New York | 11501 | United States | Details |
| Laura and Isaac Perlmutter Cancer Center at NYU Langone | Recruiting | New York | New York | 10016 | United States | Details |
| NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center | Recruiting | New York | New York | 10032 | United States | Details |
| Memorial Sloan Kettering Cancer Center | Recruiting | New York | New York | 10065 | United States | Details |
| University of Rochester | Recruiting | Rochester | New York | 14642 | United States | Details |
| Stony Brook University Medical Center | Recruiting | Stony Brook | New York | 11794 | United States | Details |
| State University of New York Upstate Medical University | Recruiting | Syracuse | New York | 13210 | United States | Details |
| UNC Lineberger Comprehensive Cancer Center | Recruiting | Chapel Hill | North Carolina | 27599 | United States | Details |
| Carolinas Medical Center/Levine Cancer Institute | Recruiting | Charlotte | North Carolina | 28203 | United States | Details |
| Duke University Medical Center | Recruiting | Durham | North Carolina | 27710 | United States | Details |
| East Carolina University | Recruiting | Greenville | North Carolina | 27834 | United States | Details |
| Wake Forest University Health Sciences | Recruiting | Winston-Salem | North Carolina | 27157 | United States | Details |
| Sanford Broadway Medical Center | Suspended | Fargo | North Dakota | 58122 | United States | Details |
| Children's Hospital Medical Center of Akron | Recruiting | Akron | Ohio | 44308 | United States | Details |
| Cincinnati Children's Hospital Medical Center | Recruiting | Cincinnati | Ohio | 45229 | United States | Details |
| Rainbow Babies and Childrens Hospital | Recruiting | Cleveland | Ohio | 44106 | United States | Details |
| Cleveland Clinic Foundation | Suspended | Cleveland | Ohio | 44195 | United States | Details |
| Nationwide Children's Hospital | Recruiting | Columbus | Ohio | 43205 | United States | Details |
| Dayton Children's Hospital | Recruiting | Dayton | Ohio | 45404 | United States | Details |
| ProMedica Flower Hospital | Suspended | Sylvania | Ohio | 43560 | United States | Details |
| ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital | Recruiting | Toledo | Ohio | 43606 | United States | Details |
| University of Oklahoma Health Sciences Center | Recruiting | Oklahoma City | Oklahoma | 73104 | United States | Details |
| Legacy Emanuel Children's Hospital | Recruiting | Portland | Oregon | 97227 | United States | Details |
| Oregon Health and Science University | Recruiting | Portland | Oregon | 97239 | United States | Details |
| Children's Hospital of Philadelphia | Recruiting | Philadelphia | Pennsylvania | 19104 | United States | Details |
| Children's Hospital of Pittsburgh of UPMC | Recruiting | Pittsburgh | Pennsylvania | 15224 | United States | Details |
| Rhode Island Hospital | Recruiting | Providence | Rhode Island | 02903 | United States | Details |
| Prisma Health Richland Hospital | Recruiting | Columbia | South Carolina | 29203 | United States | Details |
| BI-LO Charities Children's Cancer Center | Recruiting | Greenville | South Carolina | 29605 | United States | Details |
| Prisma Health Cancer Institute - Eastside | Recruiting | Greenville | South Carolina | 29615 | United States | Details |
| Sanford USD Medical Center - Sioux Falls | Recruiting | Sioux Falls | South Dakota | 57117-5134 | United States | Details |
| East Tennessee Childrens Hospital | Recruiting | Knoxville | Tennessee | 37916 | United States | Details |
| The Children's Hospital at TriStar Centennial | Recruiting | Nashville | Tennessee | 37203 | United States | Details |
| Vanderbilt University/Ingram Cancer Center | Recruiting | Nashville | Tennessee | 37232 | United States | Details |
| Dell Children's Medical Center of Central Texas | Recruiting | Austin | Texas | 78723 | United States | Details |
| Driscoll Children's Hospital | Recruiting | Corpus Christi | Texas | 78411 | United States | Details |
| Medical City Dallas Hospital | Recruiting | Dallas | Texas | 75230 | United States | Details |
| UT Southwestern/Simmons Cancer Center-Dallas | Recruiting | Dallas | Texas | 75390 | United States | Details |
| El Paso Children's Hospital | Recruiting | El Paso | Texas | 79905 | United States | Details |
| Cook Children's Medical Center | Recruiting | Fort Worth | Texas | 76104 | United States | Details |
| Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center | Recruiting | Houston | Texas | 77030 | United States | Details |
| Children's Hospital of San Antonio | Recruiting | San Antonio | Texas | 78207 | United States | Details |
| Methodist Children's Hospital of South Texas | Recruiting | San Antonio | Texas | 78229 | United States | Details |
| University of Texas Health Science Center at San Antonio | Recruiting | San Antonio | Texas | 78229 | United States | Details |
| Primary Children's Hospital | Recruiting | Salt Lake City | Utah | 84113 | United States | Details |
| University of Vermont and State Agricultural College | Recruiting | Burlington | Vermont | 05405 | United States | Details |
| Inova Fairfax Hospital | Recruiting | Falls Church | Virginia | 22042 | United States | Details |
| Children's Hospital of The King's Daughters | Recruiting | Norfolk | Virginia | 23507 | United States | Details |
| Overlake Medical Center | Suspended | Bellevue | Washington | 98004 | United States | Details |
| Valley Medical Center | Suspended | Renton | Washington | 98055 | United States | Details |
| Providence Sacred Heart Medical Center and Children's Hospital | Recruiting | Spokane | Washington | 99204 | United States | Details |
| Mary Bridge Children's Hospital and Health Center | Recruiting | Tacoma | Washington | 98405 | United States | Details |
| Madigan Army Medical Center | Recruiting | Tacoma | Washington | 98431 | United States | Details |
| North Star Lodge Cancer Center at Yakima Valley Memorial Hospital | Suspended | Yakima | Washington | 98902 | United States | Details |
| United Hospital Center | Suspended | Bridgeport | West Virginia | 26330 | United States | Details |
| WVUH-Berkely Medical Center | Suspended | Martinsburg | West Virginia | 25401 | United States | Details |
| West Virginia University Healthcare | Suspended | Morgantown | West Virginia | 26506 | United States | Details |
| Camden Clark Medical Center | Suspended | Parkersburg | West Virginia | 26101 | United States | Details |
| University of Wisconsin Carbone Cancer Center | Not yet recruiting | Madison | Wisconsin | 53792 | United States | Details |
| Children's Hospital of Wisconsin | Recruiting | Milwaukee | Wisconsin | 53226 | United States | Details |
| John Hunter Children's Hospital | Recruiting | Hunter Regional Mail Centre | New South Wales | 2310 | Australia | Details |
| Sydney Children's Hospital | Suspended | Randwick | New South Wales | 2031 | Australia | Details |
| The Children's Hospital at Westmead | Recruiting | Westmead | New South Wales | 2145 | Australia | Details |
| Perth Children's Hospital | Recruiting | Perth | Western Australia | 6009 | Australia | Details |
| CancerCare Manitoba | Recruiting | Winnipeg | Manitoba | R3E 0V9 | Canada | Details |
| IWK Health Centre | Recruiting | Halifax | Nova Scotia | B3K 6R8 | Canada | Details |
| Centre Hospitalier Universitaire Sainte-Justine | Recruiting | Montreal | Quebec | H3T 1C5 | Canada | Details |
| Centre Hospitalier Universitaire de Quebec | Recruiting | Quebec | G1V 4G2 | Canada | Details | |
| University Pediatric Hospital | Recruiting | San Juan | 00926 | Puerto Rico | Details |