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| NCT ID | NCT04603495 |
| Title | Study of CPI-0610 in Myelofibrosis (MF) (MANIFEST-2) |
| Acronym | MANIFEST-2 |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Constellation Pharmaceuticals |
| Indications | |
| Therapies | |
| Age Groups: | senior | adult |
| Covered Countries | USA | NLD | ITA | GBR | FRA | ESP | DEU | CAN | BEL | AUT | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294-3300 | United States | Details | |
| Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers | Chandler | Arizona | 85224 | United States | Details | |
| UC San Diego Moores Cancer Center | La Jolla | California | 92093 | United States | Details | |
| USC/Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | United States | Details | |
| UCLA Medical Center | Los Angeles | California | 90095 | United States | Details | |
| Yale University School of Medicine | New Haven | Connecticut | 06510 | United States | Details | |
| Georgetown University | Washington | District of Columbia | 20007 | United States | Details | |
| Mayo Clinic | Jacksonville | Florida | 32224 | United States | Details | |
| University of Miami Hospital | Miami | Florida | 33136 | United States | Details | |
| Moffitt Cancer Center | Tampa | Florida | 33612 | United States | Details | |
| Northwestern | Chicago | Illinois | 60611-5975 | United States | Details | |
| University of Chicago Medical Center | Chicago | Illinois | 60637 | United States | Details | |
| Decatur Memorial Hospital Cancer Care Center of Decatur/Cancer Care Specialists of IL | Decatur | Illinois | 62526 | United States | Details | |
| Loyola University - Cardinal Bernardin Cancer Center | Maywood | Illinois | 60153 | United States | Details | |
| Franciscan Health/Indiana blood and Marrow Transplantation | Indianapolis | Indiana | 46237 | United States | Details | |
| Norton Cancer Institute, St. Matthews Campus | Louisville | Kentucky | 40207 | United States | Details | |
| University of Michigan Medical Center | Ann Arbor | Michigan | 48109 | United States | Details | |
| Washington University | Saint Louis | Missouri | 63110 | United States | Details | |
| Cancer Care Specialists | Reno | Nevada | 89511 | United States | Details | |
| Summit Medical Group - Cancer Center | Florham Park | New Jersey | 07932 | United States | Details | |
| Icahn School of Medicine at Mount Sinai | New York | New York | 10029 | United States | Details | |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | United States | Details | |
| Weill Cornell Medical College- New York Presbyterian Hospital | New York | New York | 10065 | United States | Details | |
| Cleveland Clinic Taussig Cancer Center | Cleveland | Ohio | 44195 | United States | Details | |
| Oregon Health and Science University | Portland | Oregon | 97239 | United States | Details | |
| MD Anderson Cancer Center | Houston | Texas | 77030 | United States | Details | |
| Mays Cancer Center at UT Health San Antonio MD Anderson | San Antonio | Texas | 78229 | United States | Details | |
| Center for Blood Disorders and Cellular Therapy, Swedish Cancer Institute | Seattle | Washington | 98104 | United States | Details | |
| Sydney Adventist Hospital | Wahroonga | New South Wales | 2076 | Australia | Details | |
| Icon Cancer Centre | Brisbane | Queensland | 4101 | Australia | Details | |
| Royal Adelaide Hospital | Adelaide | South Australia | 5000 | Australia | Details | |
| Monash Health | Clayton | Victoria | 3168 | Australia | Details | |
| Peninsula Private Hospital Clinical Trials Unit | Frankston | Victoria | 3199 | Australia | Details | |
| USC Clinical Trials Centre Sunshine Coast Haematology and Oncology Clinic | Buderim | QLD 4556 | Australia | Details | ||
| One Clinical Research PTY LTD | Nedlands | 6009 | Australia | Details | ||
| Calvary North Adelaide Hospital | North Adelaide | Australia | Details | |||
| LKH - Universitätsklinikum Graz; Abteilung für Hämatologie | Graz | A-8036 | Austria | Details | ||
| Krankenhaus der Elisabethinen Linz | Linz | 4020 | Austria | Details | ||
| ZNA | Antwerpen | Belgium | Details | |||
| AZ Sint-Jan | Brugge | Belgium | Details | |||
| Cliniques universitaires Saint-Luc | Brussel | 1200 | Belgium | Details | ||
| UZ Brussel | Jette | 1090 | Belgium | Details | ||
| Hôpital de Jolimont | La Louvière | 7100 | Belgium | Details | ||
| UZ Leuven | Leuven | Belgium | Details | |||
| Domaine Universitaire du Sart Tilman | Liège | 4000 | Belgium | Details | ||
| Tom Baker Cancer Centre | Calgary | Alberta | T2N 4N2 | Canada | Details | |
| University of Alberta Hospital | Edmonton | Alberta | T6G 2B7 | Canada | Details | |
| London Health Sciences Center - Victoria Hospital | London | Ontario | N6A 5W9 | Canada | Details | |
| Princess Margaret Cancer Center | Toronto | Ontario | M5G 2M9 | Canada | Details | |
| Jewish General Hospital | Montréal | Quebec | H3T 1E2 | Canada | Details | |
| Hôpital Maisonneuve-Rosemont | Montréal | H1T 2M4 | Canada | Details | ||
| The Ottawa Hospital General Campus | Ottawa | K1H 8L6 | Canada | Details | ||
| Fakultni nemocnice Hradec Kralove | Hradec Kralove | 500 05 | Czechia | Details | ||
| University Hospital Olomouc | Olomouc | 779 00 | Czechia | Details | ||
| CHU Amiens Picardie | Amiens | 80054 | France | Details | ||
| CHU Henri-Mondor | Créteil | 94010 Cedex | France | Details | ||
| Centre Hospitalier | Le Mans | 72000 | France | Details | ||
| Hopital de la Conception | Marseille | 13385 | France | Details | ||
| Hôpital l'Archet 1 | Nice | 06202 | France | Details | ||
| CHU DE NIMES _Institut de Cancérologie du Gard | Nîmes | France | Details | |||
| Centre d'Investigations Cliniques | Paris | France | Details | |||
| Centre Hospitalier Lyon Sud Secteur 1G | Pierre-Bénite | 69310 | France | Details | ||
| Chu Pontchaillou - Service Hematologie | Rennes | 35033 | France | Details | ||
| Institut de Cancérologie Lucien Neuwirth | Saint-Priest-en-Jarez | 42271 | France | Details | ||
| Hôpital Bretonneau | Tours | 37044 | France | Details | ||
| Chru Brabois | Vandœuvre-lès-Nancy | 54500 | France | Details | ||
| Universitätsklinikum Ulm | Ulm | Baden-Württemberg | 89081 | Germany | Details | |
| Hämatologisch-Onkologische Praxis Augsburg | Augsburg | Bayern | 86151 | Germany | Details | |
| Johannes Wesling Klinikum Minden | Minden | Nordrhein-Westfalen | 32429 | Germany | Details | |
| Klinikum Chemnitz, Innere Medizin III | Chemnitz | Sachsen | 09116 | Germany | Details | |
| Universitätsklinikum Halle (Saale), Krukenberg-Krebszentrum Halle (KKH) | Halle | Sachsen | 06120 | Germany | Details | |
| Universitätsklinikum Jena, Klinik für Innere Medizin II | Jena | Thüringen | 07747 | Germany | Details | |
| Universitätsklinikum Hamburg-Eppendorf (UKE), II. Medizinische Klinik und Poliklinik | Hamburg | 20251 | Germany | Details | ||
| University Hospital of Alexandroupolis | Alexandroupolis | Greece | Details | |||
| General Hospital, School of Medicine National and Kapodistrian University of Athens | Athens | Greece | Details | |||
| Laiko General Hospital | Athens | Greece | Details | |||
| Ηippokration General Hospital | Athens | Greece | Details | |||
| Princess Margaret Hospital | Hong Kong | Kowloon | Hong Kong | Details | ||
| Prince of Wales Hospital | Hong Kong | New Territories | Hong Kong | Details | ||
| : Pecs University, 1st Department of Medicine | Pécs | Pecs | 7624 | Hungary | Details | |
| Semmelweis University - Internal Medicine and Oncology Clinic | Budapest | 1088 | Hungary | Details | ||
| Debreceni Egyetem Klinikai Kozpont, Belgyogyaszati Klinika, Hematologia | Debrecen | 4032 | Hungary | Details | ||
| Petz Aladar Egyetemi Oktato Korhaz | Gyor | 9024 | Hungary | Details | ||
| Szabolcs Szatmár Bereg Megyei Kórházak és Egyetemi Oktatókórház; Jósa András Oktatókórház, Hematológia | Nyíregyháza | Hungary | Details | |||
| Barzilai Medical Center | Ashkelon | 7830604 | Israel | Details | ||
| Soroka Medical Center | Be'er Sheva | 84101 | Israel | Details | ||
| Shamir Medical Center | Be'er Ya'aqov | 60930000 | Israel | Details | ||
| Rambam Health Corporation | Haifa | 3109601 | Israel | Details | ||
| Lady Davis Carmel Medical Center | Haifa | 3436212 | Israel | Details | ||
| Wolfson Medical Center | H̱olon | Itayz@wmc.gov.il | Israel | Details | ||
| Wolfson Medical Center | H̱olon | Israel | Details | |||
| Shaarei Zedek | Jerusalem | 9103102, | Israel | Details | ||
| Hadassah University Hospital-Ein Kerem | Jerusalem | 9590300 | Israel | Details | ||
| Shaarei Zedek | Nahariya | 2210001 | Israel | Details | ||
| Rabin Medical Center - Beilinson Campus, | Petah Tikva | 49100 | Israel | Details | ||
| Sheba Medical Center | Ramat Gan | 5265601 | Israel | Details | ||
| Kaplan Medical Center | Reẖovot | 76100 | Israel | Details | ||
| Tel Aviv Sourasky Medical Center | Tel Aviv | 6423906 | Israel | Details | ||
| Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII | Bergamo | 24127 | Italy | Details | ||
| A.O.U. Policlinico S. Orsola-Malpighi | Bologna | 40138 | Italy | Details | ||
| AOU Policlinico G. Rodolico - San Marco | Catania | Italy | Details | |||
| Azienda Ospedaliera Universitaria Arcispedale Sant'Anna | Ferrara | Italy | Details | |||
| Azienda Ospedaliera Universitaria Careggi | Florence | Italy | Details | |||
| Ospedale Policlinico San Martino IRCCS | Genova | Italy | Details | |||
| IRCCS Istituto Romagnolo per lo studio dei tumori "Dino Amadori" | Meldola | Italy | Details | |||
| Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico | Milano | Italy | Details | |||
| Azienda Ospedaliera San Gerardo di Monza | Monza | Italy | Details | |||
| AOU S.Luigi Gonzaga | Orbassano | Italy | Details | |||
| Ospedale Sant'Eugenio | Rome | Italy | Details | |||
| Ospedale di Circolo e Fondazione Macchi - ASST Sette Laghi | Varese | Italy | Details | |||
| National Cancer Center | Goyang-si | Gyeonggi-do | 10408 | Korea, Republic of | Details | |
| Gyeongsang National University Hospital | Jinju-si | Gyeongsangnam-do | Korea, Republic of | Details | ||
| Inje University Haeundae Paik Hospital | Busan | 48108 | Korea, Republic of | Details | ||
| Pusan National University Hospital | Busan | 49241 | Korea, Republic of | Details | ||
| Inje University Busan Paik Hospital | Busan | Korea, Republic of | Details | |||
| Kyungpook National University Hospital | Daegu | 41944 | Korea, Republic of | Details | ||
| Daegu Catholic University Medical Center | Daegu | Korea, Republic of | Details | |||
| Keimyung University Dongsan Hospital | Daegu | Korea, Republic of | Details | |||
| Cha Bundang Medical Center Cha University | Gyeonggi-do | Korea, Republic of | Details | |||
| The Catholic University Of Korea St. Vincent Hospital | Gyeonggi-do | Korea, Republic of | Details | |||
| Gachon University Gil Medical Center | Incheon | Korea, Republic of | Details | |||
| Jeonbuk National University Hospital | Jeonju | 54907 | Korea, Republic of | Details | ||
| Severance Hospital, Yonsei University Health System | Seoul | 03722 | Korea, Republic of | Details | ||
| Korea University Guro Hospital | Seoul | 08307 | Korea, Republic of | Details | ||
| Samsung Medical Center | Seoul | 135-710 | Korea, Republic of | Details | ||
| Hanyang University Medical Center | Seoul | Korea, Republic of | Details | |||
| Korea University Anam Hospital | Seoul | Korea, Republic of | Details | |||
| Seoul National University Hospital | Seoul | Korea, Republic of | Details | |||
| The Catholic University of Korea | Seoul | Korea, Republic of | Details | |||
| The Catholic University of South Korea Seoul St. Mary's Hospital | Seoul | Korea, Republic of | Details | |||
| Ulsan University Hospital | Ulsan | Korea, Republic of | Details | |||
| Hospital Sultanah Aminah | Johor Bahru | Johor | 80100 | Malaysia | Details | |
| Hospital Sultanah Bahiyah | Alor Setar | Kedah | 05460 | Malaysia | Details | |
| Hospital Pulau Pinang | George Town | Penang | 10450 | Malaysia | Details | |
| :Hospital Ampang | Ampang | Selangor | 68000 | Malaysia | Details | |
| Sunway Medical Centre | Petaling Jaya | Selangor | 47500 | Malaysia | Details | |
| University Malaya Medical Centre | Kuala Lumpur | 59100 | Malaysia | Details | ||
| Amsterdam UMC | Amsterdam | 1081 | Netherlands | Details | ||
| Maastricht University Medical Center | Maastricht | 6229 HX | Netherlands | Details | ||
| Wojewódzki Szpital Specjalistyczny w Bialej Podlaskiej | Biała Podlaska | 21-50 | Poland | Details | ||
| Uniwersyteckie Centrum Kliniczne | Gdańsk | 80-293 | Poland | Details | ||
| Pratia Onkologia Katowice | Katowice | Poland | Details | |||
| Centrum Medyczne Pratia | Skorzewo | 60-185 | Poland | Details | ||
| Nasz Lekarz Przychodnie Medyczne | Toruń | 87-100 | Poland | Details | ||
| Hospital Universitario Central de Asturias | Oviedo | Asturias | 33011 | Spain | Details | |
| ICO Badalona - Hospital Universitari Germans Trias i Pujol | Badalona | 8916 | Spain | Details | ||
| Hospital Clinic de Barcelona | Barcelona | Spain | Details | |||
| Vall d'Hebron Institute of Oncology | Barcelona | Spain | Details | |||
| Hospital Universitario De Burgos | Burgos | 09006 | Spain | Details | ||
| Hospital San Pedro de Alcantara | Caceres | 10003 | Spain | Details | ||
| ICO Girona - Hospital Universitari de Girona | Girona | Spain | Details | |||
| Hospital Universitario de Gran Canaria Dr. Negrin | Las Palmas de Gran Canaria | 35010 | Spain | Details | ||
| Hospital Universitario Fundación Jiménez Díaz | Madrid | 28040 | Spain | Details | ||
| Complejo Hospitalario de Navarra | Pamplona | 31008 | Spain | Details | ||
| Hospital Universitario de Salamanc | Salamanca | 37007 | Spain | Details | ||
| Hospital Virgen Macarena | Sevilla | Spain | Details | |||
| Hospital Clínico Universitario de Valencia | Valencia | 46010 | Spain | Details | ||
| Chang Gung Memorial Hospital Chiayi | Chiayi City | Taiwan | Details | |||
| China Medical University Hospital | Chiayi City | Taiwan | Details | |||
| Kaohsiung Medical University Chung-Ho Memorial Hospital | Kaohsiung | Taiwan | Details | |||
| Taichung Veterans General Hospital | Taichung | Taiwan | Details | |||
| National Taiwan University Hospital | Taipei | Taiwan | Details | |||
| Songklanagarind Hospital | Songkla | Hat Yai District | 90110 | Thailand | Details | |
| Chulabhorn Hospital | Bangkok | Lak Si | 10210 | Thailand | Details | |
| Srinagarind hospital,Khon Kaen University | Khon Kaen | Mueang Khon Kaen District | 40002 | Thailand | Details | |
| King Chulalongkorn Memorial Hospital | Bangkok | Pathumwan | 10330 | Thailand | Details | |
| Rajavithi Hospital | Bangkok | Ratchathewi District | 10400 | Thailand | Details | |
| Ankara University Faculty of Medicine Cebeci Research and Application Hospital | Ankara | Turkey | Details | |||
| Dr. Abdurrahman Yurtaslan Oncology Health Application and Research Center | Ankara | Turkey | Details | |||
| Antalya Medstar Hospital | Antalya | Turkey | Details | |||
| Edirne Trakya University Faculty of Medicine Hospital | Edirne | Turkey | Details | |||
| Gaziantep University Sahinbey Research and Application Center Hospital | Gaziantep | Turkey | Details | |||
| Izmir Ege University Faculty of Medicine Hospital | İzmir | Turkey | Details | |||
| Kocaeli University Application | Kocaeli | Turkey | Details | |||
| Mersin University | Mersin | Turkey | Details | |||
| Samsun 19 Mayıs University Health Application Research Hospital | Samsun | Turkey | Details | |||
| Western General Hospital | Edinburgh | Scotland | EH4 2XU | United Kingdom | Details | |
| University Hospital of Wales | Cardiff | Wales | CF14 4XW | United Kingdom | Details | |
| Pilgrim Hospital | Boston | PE21 9QS | United Kingdom | Details | ||
| Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust | Cambridge | CB2 0QQ | United Kingdom | Details | ||
| Imperial College Healthcare NHS Trust, Hammersmith Hospital | London | W12 0HS | United Kingdom | Details | ||
| University College London Hospitals | London | United Kingdom | Details | |||
| Oxford University Hospitals NHS Foundation Trust, Department of Haematology, Cancer and Haematology Centre, Churchill Hospital | Oxford | United Kingdom | Details |