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| NCT ID | NCT05023980 |
| Title | A Study of Pirtobrutinib (LOXO-305) Versus Bendamustine Plus Rituximab (BR) in Untreated Patients With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL) (BRUIN CLL-313) |
| Recruitment | Recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Loxo Oncology, Inc. |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | ITA | FRA | ESP | AUT |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| California Research Institute | Recruiting | Los Angeles | California | 90027 | United States | Details |
| Innovative Clinical Research Institute | Recruiting | Whittier | California | 90603 | United States | Details |
| Oncology-Hematology Associates of West Broward | Recruiting | Tamarac | Florida | 33321 | United States | Details |
| Central Maine Medical Center | Recruiting | Lewiston | Maine | 04240 | United States | Details |
| Ascension St. John Hospital | Recruiting | Grosse Pointe Woods | Michigan | 48236 | United States | Details |
| New Jersey Center for Cancer Research | Recruiting | Brick | New Jersey | 08724 | United States | Details |
| Clinical Research Alliance, Inc. | Recruiting | Westbury | New York | 11590 | United States | Details |
| Liverpool Hospital | Recruiting | Liverpool | New South Wales | 2170 | Australia | Details |
| Westmead Hospital | Recruiting | Wentworthville | New South Wales | 2145 | Australia | Details |
| Peninsula Private Hospital | Recruiting | Frankston | Victoria | 3199 | Australia | Details |
| Uniklinikum Salzburg | Recruiting | Salzburg | 5020 | Austria | Details | |
| Klinik Ottakring | Recruiting | Vienna | 1160 | Austria | Details | |
| Centro Integrado de Oncologia de Curitiba | Recruiting | Curitiba | Paraná | 80810050 | Brazil | Details |
| Instituto do Câncer - Hospital São Vicente de Paulo | Recruiting | Passo Fundo | Rio Grande Do Sul | 99010090 | Brazil | Details |
| Irmandade da Santa Casa de Misericórdia de Porto Alegre | Recruiting | Porto Alegre | Rio Grande Do Sul | 90050-170 | Brazil | Details |
| Centro Gaucho Integrado - Mae de Deus Center | Recruiting | Porto Alegre | Rio Grande Do Sul | 90110270 | Brazil | Details |
| Hemocentro Unicamp | Recruiting | Campinas | São Paulo | 13083-878 | Brazil | Details |
| Fundação Doutor Amaral Carvalho | Recruiting | Jaú | São Paulo | 17210120 | Brazil | Details |
| UMHAT "Sveti Georgi" EAD | Recruiting | Plovdiv | 4000 | Bulgaria | Details | |
| UMHAT 'Sv. Ivan Rilski', EAD | Recruiting | Sofia | 1431 | Bulgaria | Details | |
| "SHATHD" EAD, Sofia | Recruiting | Sofia | 1797 | Bulgaria | Details | |
| UMHAT - Prof. Dr. Stoyan Kirkovich" AD | Recruiting | Stara Zagora | 6003 | Bulgaria | Details | |
| Anhui Provincial Cancer Hospital | Recruiting | Hefei | Anhui | 233004 | China | Details |
| Peking University First Hospital | Recruiting | Beijing | Beijing | 100034 | China | Details |
| Peking University Third Hospital | Recruiting | Beijing | Beijing | 100191 | China | Details |
| Cancer Center of Guangzhou Medical University | Recruiting | Guangzhou | Guangdong | 510000 | China | Details |
| The First Affiliated Hospital of Guangzhou Medical University | Recruiting | Guangzhou | Guangdong | 510120 | China | Details |
| Union Hospital Tongji Medical College Huazhong University of Science and Technology | Recruiting | Wuhan | Hubei | 430022 | China | Details |
| Hunan Cancer Hospital | Recruiting | Changsha | Hunan | 410013 | China | Details |
| The First Affiliated Hospital of Nanchang University | Recruiting | Nanchang | Jiangxi | 330006 | China | Details |
| Shengjing Hospital of China Medical University | Recruiting | Shenyany | Liaoning | 110022 | China | Details |
| Jiangsu Province Hospital | Recruiting | Nanjing | Nanjing | 210029 | China | Details |
| Shanghai Tongren Hospital | Recruiting | Changning District | Shanghai | 200050 | China | Details |
| West China Hospital of Sichuan University | Recruiting | Chengdu | Sichuan | 610041 | China | Details |
| Institute of hematology&blood disease hospital | Recruiting | Tianjin | Tianjin | 300020 | China | Details |
| Tianjin Medical University Cancer Institute and Hospital | Recruiting | Tianjin | Tianjin | 300060 | China | Details |
| The First People's Hospital of Hangzhou Linping District | Recruiting | Hangzhou | Zhejiang | 311100 | China | Details |
| Beijing Hospital | Recruiting | Beijing | 100730 | China | Details | |
| Chongqing Cancer Hospital | Recruiting | Chongqing | 400030 | China | Details | |
| Hainan General Hospital | Recruiting | Haikou | 570311 | China | Details | |
| Henan Cancer Hospital | Recruiting | Zhengzhou | 450008 | China | Details | |
| Fakultni nemocnice Brno | Recruiting | Brno | 62500 | Czechia | Details | |
| Fakultni nemocnice Hradec Kralove | Recruiting | Hradec Kralove | 500 05 | Czechia | Details | |
| Fakultni nemocnice Kralovske Vinohrady | Recruiting | Praha 10 | 100 34 | Czechia | Details | |
| Vseobecna fakultni nemocnice v Praze | Recruiting | Praha 2 | 12808 | Czechia | Details | |
| CHRU De Tours | Recruiting | Tours | Tours Cedex 9 | 37044 | France | Details |
| CHD Vendee | Recruiting | La Roche-sur-Yon | Vendee | 85000 | France | Details |
| Hospitalier Le Mans | Recruiting | Le Mans | 72000 | France | Details | |
| Chu Nimes/Institut De Cancerologie Du Gard | Recruiting | Nimes | 30900 | France | Details | |
| Semmelweis Egyetem | Recruiting | Budapest | 1088 | Hungary | Details | |
| Del-pesti Centrumkorhaz - Orszagos Hematologiai es Infektologiai Intezet | Recruiting | Budapest | 1097 | Hungary | Details | |
| National Institute of Oncology | Recruiting | Budapest | 1122 | Hungary | Details | |
| Debreceni Egyetem Orvos-es Egészsegtudomanyi Centrum | Recruiting | Debrecen | 4032 | Hungary | Details | |
| SzSzB Megyei Korhazak es Egyetemi Oktatokorhaz | Recruiting | Nyíregyháza | 4400 | Hungary | Details | |
| Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz | Recruiting | Székesfehérvár | 8000 | Hungary | Details | |
| Mater Misericordiae Hospital | Recruiting | Dublin 7 | Ireland | Details | ||
| IRCCS - AOU di Bologna | Recruiting | Bologna | BO | 40138 | Italy | Details |
| Azienda Ospedaliero Universitaria Pisana | Recruiting | Pisa | PI | 56126 | Italy | Details |
| Irccs Crob | Recruiting | Rionero In Vulture | Potenza | 85028 | Italy | Details |
| Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII | Recruiting | Bergamo | 24127 | Italy | Details | |
| Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia | Recruiting | Brescia | 25123 | Italy | Details | |
| Azienda Ospedaliera Universitaria Careggi | Recruiting | Firenze | 50134 | Italy | Details | |
| Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori | Recruiting | Meldola | 47014 | Italy | Details | |
| Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico | Recruiting | Milano | 20122 | Italy | Details | |
| ASST Grande Ospedale Metropolitano Niguarda Comitato Etico Milano Area C | Recruiting | Milano | 20162 | Italy | Details | |
| Azienda Socio Sanitaria Territoriale di Monza (Presidio San Gerardo) | Recruiting | Monza | 20900 | Italy | Details | |
| Azienda Ospedale Maggiore Della Carita | Recruiting | Novara | 28100 | Italy | Details | |
| Azienda Ospedaliera Vincenzo Cervello | Recruiting | Palermo | 90146 | Italy | Details | |
| Istituto di Ematologia-C.R.E.O. (Centro di Ricerche Emato-Oncologich) | Recruiting | Perugia | 06132 | Italy | Details | |
| Ospedale Santa Maria delle Croci | Recruiting | Ravenna | 48020 | Italy | Details | |
| Fondazione Policlinico Universitario Agostino Gemelli | Recruiting | Roma | 00168 | Italy | Details | |
| Azienda Ospedaliera Santa Maria Terni | Recruiting | Terni | 05100 | Italy | Details | |
| A.O.U. Citta' della Salute e della Scienza di Torino | Recruiting | Torino | 10126 | Italy | Details | |
| Azienda Ospedaliera Card. G. Panico | Recruiting | Tricase (Le) | 73039 | Italy | Details | |
| Azienda sanitaria integrata università di Trieste | Recruiting | Trieste | 34125 | Italy | Details | |
| Nagoya Medical Center | Recruiting | Nagoya | Aichi | 460-0001 | Japan | Details |
| Nagoya City University Hospital | Recruiting | Nagoya | Aichi | 467-8602 | Japan | Details |
| Chiba Cancer Center | Recruiting | Chiba-Shi | Chiba | 260-8717 | Japan | Details |
| Fukui Medical University Hospital | Recruiting | Yoshida-Gun | Fukui | 910-1193 | Japan | Details |
| Our Lady of the Snow St. Mary's Hospital | Recruiting | Kurume-shi | Fukuoka-Ken | 830 8543 | Japan | Details |
| Hospital of University of Occupational and Environmental Health | Recruiting | Kitakyushu-shi | Fukuoka | 807 8556 | Japan | Details |
| NHO Mito Medical Center | Recruiting | Ibaraki-machi | HigaShiibaraki-Gun | 311 3193 | Japan | Details |
| Hokkaido University Hospital | Recruiting | Sapporo | Hokkaido | 060-8648 | Japan | Details |
| Kanagawa cancer center | Recruiting | Yokohama | Kanagawa | 241-8515 | Japan | Details |
| Kochi Medical School Hospital | Recruiting | Nankoku | Kochi | 783-8505 | Japan | Details |
| Tohoku University Hospital | Recruiting | Sendai-shi | Miyagi | 980-8574 | Japan | Details |
| Saitama Medical Center | Recruiting | Kawagoe | Saitama | 350-8550 | Japan | Details |
| Dokkyo Medical University - Koshigaya Hospital | Recruiting | Koshigaya | Saitama | 343 8555 | Japan | Details |
| University of Yamanashi Hospital | Recruiting | Chuo | Yamanshi | 409-3821 | Japan | Details |
| JCHO Kyushu Hospital | Recruiting | Fukoka-ken | 806 8501 | Japan | Details | |
| Kagoshima University Hospital | Recruiting | Kagoshima | 890-8520 | Japan | Details | |
| Okayama University Hospital | Recruiting | Okayama | 700-8558 | Japan | Details | |
| Gachon University Gil Medical Center | Recruiting | Namdong-gu | Incheon-gwangyeoksi [Incheon] | 21565 | Korea, Republic of | Details |
| Seoul National University Hospital | Recruiting | Seoul | Seoul, Korea | 03080 | Korea, Republic of | Details |
| Severance Hospital, Yonsei University Health System | Recruiting | Seoul | Seoul-teukbyeolsi [Seoul] | 03722 | Korea, Republic of | Details |
| Samsung Medical Center | Recruiting | Seoul | Seoul-teukbyeolsi [Seoul] | 06351 | Korea, Republic of | Details |
| The Catholic University of Korea-Seoul St. Mary's Hospital | Recruiting | Seocho-Gu | Seoul | 06591 | Korea, Republic of | Details |
| Inje Univ Busan Paik Hospital | Recruiting | Busan | 47392 | Korea, Republic of | Details | |
| North Shore Hospital, Haematology Research | Recruiting | Takapuna | Auckland | 0622 | New Zealand | Details |
| Tauranga Hospital | Recruiting | Tauranga | Bay Of Plenty | 3112 | New Zealand | Details |
| Christchurch Hospital | Recruiting | Christchurch | 8011 | New Zealand | Details | |
| Middlemore Clinical Trials | Recruiting | Papatoetoe | 2025 | New Zealand | Details | |
| Wojewodzki Szpital Specjalistyczny | Recruiting | Iwaszkiewicza 5 | Legnica | 59-220 | Poland | Details |
| Klinika Hematoonkologii i Transplantacji Szpiku SPSK1 Lublin | Recruiting | Lublin | Lubelskie V | 20081 | Poland | Details |
| Uniwersyteckie Centrum Kliniczne | Recruiting | Gdańsk | Pomorskie | 80214 | Poland | Details |
| Centrum Medyczne Pratia Poznan | Recruiting | Skorzewo | Poznan | 60 185 | Poland | Details |
| KO-MED Centra Kliniczne | Recruiting | Biała Podlaska | 21500 | Poland | Details | |
| Szpital Uniwersytecki nr 2 im. dr Jana Biziela w BydgoszczyKlinika Hematologii | Recruiting | Bydgoszcz | 85-168 | Poland | Details | |
| Pratia Onkologia Katowice | Recruiting | Katowice | 40519 | Poland | Details | |
| Pratia MCM Krakow | Recruiting | Kraków | 30-510 | Poland | Details | |
| Centrum Onkologii Ziemi Lubelskiej | Recruiting | Lublin | 20-090 | Poland | Details | |
| Szpital Wojewodzki w Opolu | Recruiting | Opole | 45061 | Poland | Details | |
| Nasz Lekarz Osrodek Badan Klinicznych | Recruiting | Toruń | 87-100 | Poland | Details | |
| Narodowy Instytut Onkologii im. Marii Skłodowskiej-Cuire - Państwowy Instytut Badawczy | Recruiting | Warsaw | 02781 | Poland | Details | |
| Uniwersytecki Szpital Kliniczny Klinika | Recruiting | Wrocław | 50-367 | Poland | Details | |
| Centro Clínico Académico - Braga (2CA-Braga) (Hospital de Braga) | Recruiting | Braga | 4710-243 | Portugal | Details | |
| Centro Hospitalar de Lisboa Norte, E.P.E. - Hospital de Santa Maria | Recruiting | Lisboa | 1649035 | Portugal | Details | |
| Instituto Português de Oncologia do Porto Francisco Gentil, EPE | Recruiting | Porto | 4200-072 | Portugal | Details | |
| Hospital de Sao Joao E.P.E. | Recruiting | Porto | 4200-319 | Portugal | Details | |
| Centro Hospitalar de Vila Nova de Gaia | Recruiting | Vila Nova De Gaia | 4434-536 | Portugal | Details | |
| Spitalul Clinic Municipal Filantropia Craiova | Recruiting | Craiova | Dolj | 200143 | Romania | Details |
| Spitalul Clinic Colentina | Recruiting | Bucuresti | 020125 | Romania | Details | |
| Institutul Clinic Fundeni - Centrul de Hematologie si Transplant Medular | Recruiting | Bucuresti | 022328 | Romania | Details | |
| Spitalul Clinic Coltea | Recruiting | Bucuresti | 030171 | Romania | Details | |
| Institutul Oncologic "Prof. Dr. Ion Chiricuta" Cluj-Napoca | Recruiting | Cluj-Napoca | 400015 | Romania | Details | |
| Institutului Regional de Oncologie IASI | Recruiting | Iasi | 700483 | Romania | Details | |
| Spitalul Clinic Judetean De Urgenta Oradea | Recruiting | Oradea | 410469 | Romania | Details | |
| Spitalul Clinic Judetean de Urgenta Targu Mures | Recruiting | Targu Mures | 540136 | Romania | Details | |
| Budgetary Healthcare Institution of Omsk Region "Clinical Oncology Dispensary" | Recruiting | Omsk | Omskaya Oblast | 644013 | Russian Federation | Details |
| Regional Oncology Dispensary | Recruiting | Penza | 440071 | Russian Federation | Details | |
| Academician I.P. Pavlov First St-Petersburg State Medical University | Recruiting | St-Petersburg | 197022 | Russian Federation | Details | |
| Hospital Universitario Central de Asturias | Recruiting | Oviedo | Asturias | 33011 | Spain | Details |
| Hospital Universitario HM Sanchinarro | Recruiting | Madrid | Madrid, Comunidad De | 28050 | Spain | Details |
| Hospital Universitario Puerta de Hierro Majadahonda | Recruiting | Majadahonda | Madrid | 28222 | Spain | Details |
| Hospital de la Santa Creu i Sant Pau | Recruiting | Barcelona | 08041 | Spain | Details | |
| Hospital Duran I Reynals | Recruiting | L'Hospitalet De Llobregat | 08908 | Spain | Details | |
| Hospital Universitario Fundación Jiménez Díaz | Recruiting | Madrid | 28040 | Spain | Details | |
| Hospital Universitario Virgen del Rocío | Recruiting | Sevilla | 41013 | Spain | Details | |
| Hospital Universitario Virgen de Valme | Recruiting | Sevilla | 41014 | Spain | Details | |
| Chang Bing Show Chwan Memorial Hospital | Recruiting | Changhua | 50544 | Taiwan | Details | |
| Kaohsiung Medical University Chung-Ho Memorial Hospital | Recruiting | Kaohsiung | 807 | Taiwan | Details | |
| China Medical University Hospital | Recruiting | Taichung | 40447 | Taiwan | Details | |
| National Taiwan University Hospital | Recruiting | Taipei | 10002 | Taiwan | Details | |
| Chang Gung Memorial Hospital - Linkou | Recruiting | Taoyuan City | 333 | Taiwan | Details | |
| Birmingham Heartlands Hospital | Recruiting | Birmingham | England | B9 5SS | United Kingdom | Details |
| New Cross Hospital | Recruiting | Wolverhampton | WV10 0QP | United Kingdom | Details |