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| NCT ID | NCT05023980 |
| Title | A Study of Pirtobrutinib (LOXO-305) Versus Bendamustine Plus Rituximab (BR) in Untreated Patients With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL) (BRUIN CLL-313) |
| Acronym | BRUIN CLL-313 |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Loxo Oncology, Inc. |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | NZL | ITA | GBR | FRA | ESP | AUT | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| California Research Institute | Los Angeles | California | 90027 | United States | Details | |
| Innovative Clinical Research Institute | Whittier | California | 90603 | United States | Details | |
| Oncology-Hematology Associates of West Broward | Tamarac | Florida | 33321 | United States | Details | |
| Central Maine Medical Center | Lewiston | Maine | 04240 | United States | Details | |
| Ascension St. John Hospital | Grosse Pointe Woods | Michigan | 48236 | United States | Details | |
| New Jersey Center for Cancer Research | Brick | New Jersey | 08724 | United States | Details | |
| Clinical Research Alliance, Inc. | Westbury | New York | 11590 | United States | Details | |
| Liverpool Hospital | Liverpool | New South Wales | 2170 | Australia | Details | |
| Westmead Hospital | Wentworthville | New South Wales | 2145 | Australia | Details | |
| Peninsula Private Hospital | Frankston | Victoria | 3199 | Australia | Details | |
| Uniklinikum Salzburg | Salzburg | 5020 | Austria | Details | ||
| Klinik Ottakring | Vienna | 1160 | Austria | Details | ||
| Centro Integrado de Oncologia de Curitiba | Curitiba | Paraná | 80810050 | Brazil | Details | |
| Instituto do Câncer - Hospital São Vicente de Paulo | Passo Fundo | Rio Grande Do Sul | 99010090 | Brazil | Details | |
| Irmandade da Santa Casa de Misericórdia de Porto Alegre | Porto Alegre | Rio Grande Do Sul | 90050-170 | Brazil | Details | |
| Centro Gaucho Integrado - Mae de Deus Center | Porto Alegre | Rio Grande Do Sul | 90110270 | Brazil | Details | |
| Hemocentro Unicamp | Campinas | São Paulo | 13083-878 | Brazil | Details | |
| Fundação Doutor Amaral Carvalho | Jaú | São Paulo | 17210120 | Brazil | Details | |
| UMHAT "Sveti Georgi" EAD | Plovdiv | 4000 | Bulgaria | Details | ||
| UMHAT 'Sv. Ivan Rilski', EAD | Sofia | 1431 | Bulgaria | Details | ||
| "SHATHD" EAD, Sofia | Sofia | 1797 | Bulgaria | Details | ||
| UMHAT - Prof. Dr. Stoyan Kirkovich" AD | Stara Zagora | 6003 | Bulgaria | Details | ||
| Anhui Provincial Cancer Hospital | Hefei | Anhui | 233004 | China | Details | |
| Peking University First Hospital | Beijing | Beijing | 100034 | China | Details | |
| Peking University Third Hospital | Beijing | Beijing | 100191 | China | Details | |
| Cancer Center of Guangzhou Medical University | Guangzhou | Guangdong | 510000 | China | Details | |
| The First Affiliated Hospital of Guangzhou Medical University | Guangzhou | Guangdong | 510120 | China | Details | |
| Union Hospital Tongji Medical College Huazhong University of Science and Technology | Wuhan | Hubei | 430022 | China | Details | |
| Hunan Cancer Hospital | Changsha | Hunan | 410013 | China | Details | |
| The First Affiliated Hospital of Nanchang University | Nanchang | Jiangxi | 330006 | China | Details | |
| Shengjing Hospital of China Medical University | Shenyany | Liaoning | 110022 | China | Details | |
| Jiangsu Province Hospital | Nanjing | Nanjing | 210029 | China | Details | |
| Shanghai Tongren Hospital | Changning District | Shanghai | 200050 | China | Details | |
| West China Hospital of Sichuan University | Chengdu | Sichuan | 610041 | China | Details | |
| Institute of hematology&blood disease hospital | Tianjin | Tianjin | 300020 | China | Details | |
| Tianjin Medical University Cancer Institute and Hospital | Tianjin | Tianjin | 300060 | China | Details | |
| The First People's Hospital of Hangzhou Linping District | Hangzhou | Zhejiang | 311100 | China | Details | |
| Beijing Hospital | Beijing | 100730 | China | Details | ||
| Chongqing Cancer Hospital | Chongqing | 400030 | China | Details | ||
| Hainan General Hospital | Haikou | 570311 | China | Details | ||
| Henan Cancer Hospital | Zhengzhou | 450008 | China | Details | ||
| Fakultni nemocnice Brno | Brno | 62500 | Czechia | Details | ||
| Fakultni nemocnice Hradec Kralove | Hradec Kralove | 500 05 | Czechia | Details | ||
| Fakultni nemocnice Kralovske Vinohrady | Praha 10 | 100 34 | Czechia | Details | ||
| Vseobecna fakultni nemocnice v Praze | Praha 2 | 12808 | Czechia | Details | ||
| CHRU De Tours | Tours | Tours Cedex 9 | 37044 | France | Details | |
| CHD Vendee | La Roche-sur-Yon | Vendee | 85000 | France | Details | |
| Hospitalier Le Mans | Le Mans | 72000 | France | Details | ||
| Chu Nimes/Institut De Cancerologie Du Gard | Nimes | 30900 | France | Details | ||
| Semmelweis Egyetem | Budapest | 1088 | Hungary | Details | ||
| Del-pesti Centrumkorhaz - Orszagos Hematologiai es Infektologiai Intezet | Budapest | 1097 | Hungary | Details | ||
| National Institute of Oncology | Budapest | 1122 | Hungary | Details | ||
| Debreceni Egyetem Orvos-es Egészsegtudomanyi Centrum | Debrecen | 4032 | Hungary | Details | ||
| SzSzB Megyei Korhazak es Egyetemi Oktatokorhaz | Nyíregyháza | 4400 | Hungary | Details | ||
| Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz | Székesfehérvár | 8000 | Hungary | Details | ||
| Mater Misericordiae Hospital | Dublin 7 | Ireland | Details | |||
| IRCCS - AOU di Bologna | Bologna | BO | 40138 | Italy | Details | |
| Azienda Ospedaliero Universitaria Pisana | Pisa | PI | 56126 | Italy | Details | |
| Irccs Crob | Rionero In Vulture | Potenza | 85028 | Italy | Details | |
| Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII | Bergamo | 24127 | Italy | Details | ||
| Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia | Brescia | 25123 | Italy | Details | ||
| Azienda Ospedaliera Universitaria Careggi | Firenze | 50134 | Italy | Details | ||
| Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori | Meldola | 47014 | Italy | Details | ||
| Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico | Milano | 20122 | Italy | Details | ||
| ASST Grande Ospedale Metropolitano Niguarda Comitato Etico Milano Area C | Milano | 20162 | Italy | Details | ||
| Azienda Socio Sanitaria Territoriale di Monza (Presidio San Gerardo) | Monza | 20900 | Italy | Details | ||
| Azienda Ospedale Maggiore Della Carita | Novara | 28100 | Italy | Details | ||
| Azienda Ospedaliera Vincenzo Cervello | Palermo | 90146 | Italy | Details | ||
| Istituto di Ematologia-C.R.E.O. (Centro di Ricerche Emato-Oncologich) | Perugia | 06132 | Italy | Details | ||
| Ospedale Santa Maria delle Croci | Ravenna | 48020 | Italy | Details | ||
| Fondazione Policlinico Universitario Agostino Gemelli | Roma | 00168 | Italy | Details | ||
| Azienda Ospedaliera Santa Maria Terni | Terni | 05100 | Italy | Details | ||
| A.O.U. Citta' della Salute e della Scienza di Torino | Torino | 10126 | Italy | Details | ||
| Azienda Ospedaliera Card. G. Panico | Tricase (Le) | 73039 | Italy | Details | ||
| Azienda sanitaria integrata università di Trieste | Trieste | 34125 | Italy | Details | ||
| Nagoya Medical Center | Nagoya | Aichi | 460-0001 | Japan | Details | |
| Nagoya City University Hospital | Nagoya | Aichi | 467-8602 | Japan | Details | |
| Chiba Cancer Center | Chiba-Shi | Chiba | 260-8717 | Japan | Details | |
| Fukui Medical University Hospital | Yoshida-Gun | Fukui | 910-1193 | Japan | Details | |
| Our Lady of the Snow St. Mary's Hospital | Kurume-shi | Fukuoka-Ken | 830 8543 | Japan | Details | |
| Hospital of University of Occupational and Environmental Health | Kitakyushu-shi | Fukuoka | 807 8556 | Japan | Details | |
| NHO Mito Medical Center | Ibaraki-machi | HigaShiibaraki-Gun | 311 3193 | Japan | Details | |
| Hokkaido University Hospital | Sapporo | Hokkaido | 060-8648 | Japan | Details | |
| Kanagawa cancer center | Yokohama | Kanagawa | 241-8515 | Japan | Details | |
| Kochi Medical School Hospital | Nankoku | Kochi | 783-8505 | Japan | Details | |
| Tohoku University Hospital | Sendai-shi | Miyagi | 980-8574 | Japan | Details | |
| Saitama Medical Center | Kawagoe | Saitama | 350-8550 | Japan | Details | |
| Dokkyo Medical University - Koshigaya Hospital | Koshigaya | Saitama | 343 8555 | Japan | Details | |
| University of Yamanashi Hospital | Chuo | Yamanshi | 409-3821 | Japan | Details | |
| JCHO Kyushu Hospital | Fukoka-ken | 806 8501 | Japan | Details | ||
| Kagoshima University Hospital | Kagoshima | 890-8520 | Japan | Details | ||
| Okayama University Hospital | Okayama | 700-8558 | Japan | Details | ||
| Gachon University Gil Medical Center | Namdong-gu | Incheon-gwangyeoksi [Incheon] | 21565 | Korea, Republic of | Details | |
| Seoul National University Hospital | Seoul | Seoul, Korea | 03080 | Korea, Republic of | Details | |
| Severance Hospital, Yonsei University Health System | Seoul | Seoul-teukbyeolsi [Seoul] | 03722 | Korea, Republic of | Details | |
| Samsung Medical Center | Seoul | Seoul-teukbyeolsi [Seoul] | 06351 | Korea, Republic of | Details | |
| The Catholic University of Korea-Seoul St. Mary's Hospital | Seocho-Gu | Seoul | 06591 | Korea, Republic of | Details | |
| Inje Univ Busan Paik Hospital | Busan | 47392 | Korea, Republic of | Details | ||
| North Shore Hospital, Haematology Research | Takapuna | Auckland | 0622 | New Zealand | Details | |
| Tauranga Hospital | Tauranga | Bay Of Plenty | 3112 | New Zealand | Details | |
| Christchurch Hospital | Christchurch | 8011 | New Zealand | Details | ||
| Middlemore Clinical Trials | Papatoetoe | 2025 | New Zealand | Details | ||
| Wojewodzki Szpital Specjalistyczny | Iwaszkiewicza 5 | Legnica | 59-220 | Poland | Details | |
| Klinika Hematoonkologii i Transplantacji Szpiku SPSK1 Lublin | Lublin | Lubelskie V | 20081 | Poland | Details | |
| Uniwersyteckie Centrum Kliniczne | Gdańsk | Pomorskie | 80214 | Poland | Details | |
| Centrum Medyczne Pratia Poznan | Skorzewo | Poznan | 60 185 | Poland | Details | |
| KO-MED Centra Kliniczne | Biała Podlaska | 21500 | Poland | Details | ||
| Szpital Uniwersytecki nr 2 im. dr Jana Biziela w BydgoszczyKlinika Hematologii | Bydgoszcz | 85-168 | Poland | Details | ||
| Pratia Onkologia Katowice | Katowice | 40519 | Poland | Details | ||
| Pratia MCM Krakow | Kraków | 30-510 | Poland | Details | ||
| Centrum Onkologii Ziemi Lubelskiej | Lublin | 20-090 | Poland | Details | ||
| Szpital Wojewodzki w Opolu | Opole | 45061 | Poland | Details | ||
| Nasz Lekarz Osrodek Badan Klinicznych | Toruń | 87-100 | Poland | Details | ||
| Narodowy Instytut Onkologii im. Marii Skłodowskiej-Cuire - Państwowy Instytut Badawczy | Warsaw | 02781 | Poland | Details | ||
| Uniwersytecki Szpital Kliniczny Klinika | Wrocław | 50-367 | Poland | Details | ||
| Centro Clínico Académico - Braga (2CA-Braga) (Hospital de Braga) | Braga | 4710-243 | Portugal | Details | ||
| Centro Hospitalar de Lisboa Norte, E.P.E. - Hospital de Santa Maria | Lisboa | 1649035 | Portugal | Details | ||
| Instituto Português de Oncologia do Porto Francisco Gentil, EPE | Porto | 4200-072 | Portugal | Details | ||
| Hospital de Sao Joao E.P.E. | Porto | 4200-319 | Portugal | Details | ||
| Centro Hospitalar de Vila Nova de Gaia | Vila Nova De Gaia | 4434-536 | Portugal | Details | ||
| Spitalul Clinic Municipal Filantropia Craiova | Craiova | Dolj | 200143 | Romania | Details | |
| Spitalul Clinic Colentina | Bucuresti | 020125 | Romania | Details | ||
| Institutul Clinic Fundeni - Centrul de Hematologie si Transplant Medular | Bucuresti | 022328 | Romania | Details | ||
| Spitalul Clinic Coltea | Bucuresti | 030171 | Romania | Details | ||
| Institutul Oncologic "Prof. Dr. Ion Chiricuta" Cluj-Napoca | Cluj-Napoca | 400015 | Romania | Details | ||
| Institutului Regional de Oncologie IASI | Iasi | 700483 | Romania | Details | ||
| Spitalul Clinic Judetean De Urgenta Oradea | Oradea | 410469 | Romania | Details | ||
| Spitalul Clinic Judetean de Urgenta Targu Mures | Targu Mures | 540136 | Romania | Details | ||
| Budgetary Healthcare Institution of Omsk Region "Clinical Oncology Dispensary" | Omsk | Omskaya Oblast | 644013 | Russian Federation | Details | |
| Regional Oncology Dispensary | Penza | 440071 | Russian Federation | Details | ||
| Academician I.P. Pavlov First St-Petersburg State Medical University | St-Petersburg | 197022 | Russian Federation | Details | ||
| Hospital Universitario Central de Asturias | Oviedo | Asturias | 33011 | Spain | Details | |
| Hospital Universitario HM Sanchinarro | Madrid | Madrid, Comunidad De | 28050 | Spain | Details | |
| Hospital Universitario Puerta de Hierro Majadahonda | Majadahonda | Madrid | 28222 | Spain | Details | |
| Hospital de la Santa Creu i Sant Pau | Barcelona | 08041 | Spain | Details | ||
| Hospital Duran I Reynals | L'Hospitalet De Llobregat | 08908 | Spain | Details | ||
| Hospital Universitario Fundación Jiménez Díaz | Madrid | 28040 | Spain | Details | ||
| Hospital Universitario Virgen del Rocío | Sevilla | 41013 | Spain | Details | ||
| Hospital Universitario Virgen de Valme | Sevilla | 41014 | Spain | Details | ||
| Chang Bing Show Chwan Memorial Hospital | Changhua | 50544 | Taiwan | Details | ||
| Kaohsiung Medical University Chung-Ho Memorial Hospital | Kaohsiung | 807 | Taiwan | Details | ||
| China Medical University Hospital | Taichung | 40447 | Taiwan | Details | ||
| National Taiwan University Hospital | Taipei | 10002 | Taiwan | Details | ||
| Chang Gung Memorial Hospital - Linkou | Taoyuan City | 333 | Taiwan | Details | ||
| Birmingham Heartlands Hospital | Birmingham | England | B9 5SS | United Kingdom | Details | |
| New Cross Hospital | Wolverhampton | WV10 0QP | United Kingdom | Details |