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| NCT ID | NCT05254743 |
| Title | A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL) (BRUIN-CLL-314) |
| Recruitment | Recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Loxo Oncology, Inc. |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | ITA | FRA | ESP | DEU | CAN | BEL | AUT |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Genesis Cancer Center | Recruiting | Hot Springs | Arkansas | 71913 | United States | Details |
| Pacific Cancer Medical Center, Inc | Recruiting | Anaheim | California | 92801 | United States | Details |
| Alta Bates Comprehensive Cancer Center | Not yet recruiting | Berkeley | California | 94704 | United States | Details |
| Eisenhower Army Medical Center | Recruiting | Rancho Mirage | California | 92270 | United States | Details |
| California Cancer Associates for Research and Excellence | Recruiting | San Marcos | California | 92069 | United States | Details |
| Innovative Clinical Research Institute | Recruiting | Whittier | California | 90603 | United States | Details |
| Eastern Ct Hematology and Oncology Associates | Recruiting | Norwich | Connecticut | 06360 | United States | Details |
| Asclepes Research Centers Florida | Recruiting | Brooksville | Florida | 34613 | United States | Details |
| Florida Cancer Specialists | Recruiting | Fort Myers | Florida | 33901 | United States | Details |
| Cancer Specialists of North Florida -St Augustine | Recruiting | Jacksonville | Florida | 32256 | United States | Details |
| Hollis Cancer Center | Recruiting | Lakeland | Florida | 33805 | United States | Details |
| Florida Cancer Specialists | Recruiting | Saint Petersburg | Florida | 33705 | United States | Details |
| Florida Cancer Specialists East | Recruiting | West Palm Beach | Florida | 33401 | United States | Details |
| Northwest Georgia Oncology Centers | Not yet recruiting | Marietta | Georgia | 30060 | United States | Details |
| St Josephs-Candler Health System Inc | Not yet recruiting | Savannah | Georgia | 31405 | United States | Details |
| Baptist Healthcare System, Inc. | Not yet recruiting | Louisville | Kentucky | 40207 | United States | Details |
| Hematology Oncology Clinic | Recruiting | Baton Rouge | Louisiana | 70809 | United States | Details |
| Tulane Cancer Center Office of Clinical Research | Recruiting | New Orleans | Louisiana | 70112 | United States | Details |
| American Oncology Partners of Maryland, PA | Recruiting | Bethesda | Maryland | 20817 | United States | Details |
| TidalHealth Richard A. Henson Cancer Institute | Recruiting | Ocean Pines | Maryland | 21811 | United States | Details |
| TidalHealth Peninsula Regional, Inc. | Recruiting | Salisbury | Maryland | 21801 | United States | Details |
| Karmanos Cancer Institute | Recruiting | Detroit | Michigan | 48201 | United States | Details |
| St. Vincent Frontier Cancer Center | Recruiting | Billings | Montana | 59102 | United States | Details |
| New York Medical College | Not yet recruiting | New York | New York | 10532 | United States | Details |
| Novant Cancer Institute Charlotte | Recruiting | Charlotte | North Carolina | 28204 | United States | Details |
| Novant Health, Oncology Research Institute | Recruiting | Winston-Salem | North Carolina | 27103 | United States | Details |
| Asante Rogue Regional Medical Center | Recruiting | Medford | Oregon | 97504 | United States | Details |
| Cancer Care Associates of York | Recruiting | York | Pennsylvania | 17403 | United States | Details |
| Prisma Health Cancer Institute | Recruiting | Greenville | South Carolina | 29615 | United States | Details |
| Sarah Cannon Research Institute SCRI | Recruiting | Chattanooga | Tennessee | 37404 | United States | Details |
| UTHSC Clinical Trails Unit | Not yet recruiting | Memphis | Tennessee | 38104 | United States | Details |
| Brooke Army Medical Center | Recruiting | Fort Sam Houston | Texas | 78234 | United States | Details |
| Kelsey Research Foundation | Recruiting | Houston | Texas | 77025 | United States | Details |
| Houston Methodist Cancer Center | Recruiting | Houston | Texas | 77030 | United States | Details |
| Lumi Research | Recruiting | Kingwood | Texas | 77339 | United States | Details |
| Baylor Scott and White Medical Center Round Rock | Recruiting | Round Rock | Texas | 78665 | United States | Details |
| Virginia Cancer Institute | Recruiting | Richmond | Virginia | 23228 | United States | Details |
| MultiCare Health System Institute for Research and Innovation | Not yet recruiting | Spokane | Washington | 99218 | United States | Details |
| Fundaleu | Recruiting | Autonoma De Buenos Aires | Buenos Aires | 1114 | Argentina | Details |
| Instituto Alexander Fleming | Recruiting | Ciudad Autónoma de Buenos Aire | Buenos Aires | C1426ANZ | Argentina | Details |
| Hospital Privado De Comunidad | Recruiting | Mar Del Plata | Buenos Aires | 7600 | Argentina | Details |
| Hospital Italiano de Buenos Aires | Recruiting | ABB | Ciudad Autónoma De Buenos Aire | 1199 | Argentina | Details |
| Sanatorio Allende-Cordoba | Not yet recruiting | Cordoba | X5000GXA | Argentina | Details | |
| Hospital Privado Centro Medico de Cordoba SA | Not yet recruiting | Cordoba | X5016KEH | Argentina | Details | |
| Clínica de Nefrología, Urología y Enfermedades Cardiovasculares | Recruiting | Santa Fe | 3000 | Argentina | Details | |
| One Clinical Research | Recruiting | Nedlands | Western Australia | 6009 | Australia | Details |
| The Perth Blood Institute | Recruiting | West Perth | 6005 | Australia | Details | |
| Ordensklinikum Linz | Not yet recruiting | Linz | Oberösterreich | 4020 | Austria | Details |
| Ordensklinikum Linz GmbH Elisabethinen | Not yet recruiting | Linz | 4020 | Austria | Details | |
| VITAZ | Recruiting | Sint-Niklaas | Oost-Vlaanderen | 9100 | Belgium | Details |
| AZ Delta | Recruiting | Roeselare | West Flanders | 8800 | Belgium | Details |
| Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg | Recruiting | Leuven | 3000 | Belgium | Details | |
| Centro de Pesquisas Clínicas do Hospital das Clínicas da UFMG - Ebserh | Not yet recruiting | Belo Horizonte | Minas Gera | 30130-100 | Brazil | Details |
| Centro Integrado de Oncologia de Curitiba | Not yet recruiting | Curitiba | Paraná | 80810-050 | Brazil | Details |
| Hospital Erasto Gaertner - Liga Paranaense de Combate ao Câncer | Not yet recruiting | Curitiba | Paraná | 81520060 | Brazil | Details |
| Instituto do Câncer - Hospital São Vicente de Paulo | Recruiting | Passo Fundo | Rio Grande Do Sul | 99010090 | Brazil | Details |
| Centro Gaucho Integrado - Mae de Deus Center | Recruiting | Porto Alegre | Rio Grande Do Sul | 90110270 | Brazil | Details |
| Hospital Santa Marcelina | Recruiting | Sao Paulo | SP | 08270-120 | Brazil | Details |
| Fundação Pio XII - Hospital de Câncer de Barretos | Not yet recruiting | Barretos | São Paulo | 14784-400 | Brazil | Details |
| Upeclin - Unidade de Pesquisa Clínica da Faculdade de Medicina de Botucatu - UNESP | Recruiting | Botucatu | São Paulo | 18618-686 | Brazil | Details |
| Hemocentro Unicamp | Recruiting | Campinas | São Paulo | 13083-878 | Brazil | Details |
| Hospital de Clínicas de Ribeirão Preto | Recruiting | Ribeirão Preto | São Paulo | 14051-140 | Brazil | Details |
| CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia | Recruiting | Santo André | São Paulo | 09060-650 | Brazil | Details |
| BP - A Beneficencia Portuguesa de São Paulo | Recruiting | Sao Paulo | São Paulo | 01321-001 | Brazil | Details |
| Hospital Uopeccan - Centro de Pesquisa Clinica | Recruiting | Cascavel | 85806-300 | Brazil | Details | |
| Centro Integrado de Pesquisa Clinica | Not yet recruiting | São José do Rio Preto | 15090-000 | Brazil | Details | |
| Hospital da Clinicas da Faculdade de Medicina da USP | Recruiting | São Paulo | 05402-000 | Brazil | Details | |
| Royal Victoria Hospital-Montreal | Recruiting | Barrie | Ontario | L4M 6M2 | Canada | Details |
| Hopital de L'Enfant Jesus | Recruiting | Québec | G1J 1Z4 | Canada | Details | |
| Sociedad de Investigaciones Médicas Limitada | Recruiting | Temuco | IX Región | 4780000 | Chile | Details |
| CeCim Biocinetic | Recruiting | Santiago | Región Metropolitana | 8320000 | Chile | Details |
| Centro de Estudios Clinicos SAGA | Recruiting | Providencia | Santiago | 7500653 | Chile | Details |
| Centro de Investigaciones Clínicas Viña del Mar (CIC) | Recruiting | Viña del Mar | Valparaíso | 2520000 | Chile | Details |
| Anhui Provincial Hospital | Recruiting | Hefei | Anhui | 230000 | China | Details |
| The Second Hospital of Anhui Medical University | Recruiting | Hefei | Anhui | 231200 | China | Details |
| Southern Medical University Nanfang Hospital | Recruiting | Guangzhou | Guangdong | 510515 | China | Details |
| Guangxi Medical University Affiliated Tumor Hospital | Recruiting | Nanning | Guangxi | 530021 | China | Details |
| Wu Han Tongji Hospital | Recruiting | Wuhan City | Hubei | 430030 | China | Details |
| The Second Xiangya Hospital of Central South University | Recruiting | Changsha | Hunan | 410011 | China | Details |
| Hunan Cancer Hospital | Recruiting | Changsha | Hunan | 410013 | China | Details |
| The First Affiliated Hospital of Nanchang University | Recruiting | Nanchang | Jiangxi | 330006 | China | Details |
| Jiangxi Provincial Cancer Hospital | Recruiting | Nanchang | Jiangxi | 330029 | China | Details |
| Tumor Hospital of Sun Yat-Sen University, Medical Science | Not yet recruiting | Guang Zhou | P.R. China | 510060 | China | Details |
| Shanghai Jiaotong University School of Medicine Ruijin Hospital | Not yet recruiting | Shanghai | Shanghai | 200025 | China | Details |
| Fudan University Shanghai Cancer Center | Recruiting | Shanghai | Shanghai | 200032 | China | Details |
| Blood Institute of the Chinese Academy of Medical science | Recruiting | Tianjin | Tianjin | 300020 | China | Details |
| Tianjin Medical University General Hospital | Recruiting | Tianjin | Tianjin | 300052 | China | Details |
| Affiliated Cancer Hospital of Xinjiang Medical University | Not yet recruiting | Urumqi | Xinjiang | 830000 | China | Details |
| The Second Affiliated Hospital of Zhejiang University School of Medicine | Recruiting | Hangzhou | Zhejiang | 310009 | China | Details |
| The Fourth Affiliated Hospital Zhejiang University School of Medicine | Not yet recruiting | Yiwu | Zhejiang | 322000 | China | Details |
| Hainan General Hospital | Recruiting | Haikou | 570311 | China | Details | |
| First Affiliated Hosp of College of Med, Zhejiang University | Recruiting | Hangzhou | 310003 | China | Details | |
| Union Hospital Tongji Medical College Huazhong University of Science and Technology | Recruiting | Wuhan | 430022 | China | Details | |
| Fakultni nemocnice Hradec Kralove | Not yet recruiting | Hradec Kralove | Hradec Králové | 500 05 | Czechia | Details |
| Fakultni nemocnice Brno | Recruiting | Brno | 62500 | Czechia | Details | |
| Fakultni Nemocnice Ostrava | Recruiting | Ostrava-Poruba | 708 52 | Czechia | Details | |
| Fakultni Nemocnice Plzen | Recruiting | Plzen - Lochotin | 30460 | Czechia | Details | |
| Fakultni nemocnice Kralovske Vinohrady | Recruiting | Praha 10 | 100 34 | Czechia | Details | |
| Vseobecna fakultni nemocnice v Praze | Recruiting | Praha 2 | 12808 | Czechia | Details | |
| Hopital de la Pitie Salpetriere | Recruiting | Paris | Cedex 13 | 75651 | France | Details |
| CHU de Nantes - Hotel Dieu | Recruiting | Nantes | Cedex 1 | 44093 | France | Details |
| Hôpital de Pontchaillou | Recruiting | Rennes | Cedex 9 | 35033 | France | Details |
| Centre Hospitalier Lyon Sud | Recruiting | Pierre Benite | Cedex | 69495 | France | Details |
| Centre Antoine Lacassagne | Recruiting | Nice | Nice Cedex 2 | 06189 | France | Details |
| CHRU De Tours | Recruiting | Tours | Tours Cedex 9 | 37044 | France | Details |
| CHD Vendee | Recruiting | La Roche sur Yon | 85000 | France | Details | |
| Centre Hospitalier du Mans | Recruiting | Le Mans | 72000 | France | Details | |
| Hématologie Clinique et Thérapie Cellulaire | Recruiting | Limoges | 87042 | France | Details | |
| Centre de Lutte Contre le Cancer - Centre Henri Becquerel Normandie Rouen | Recruiting | Rouen Cedex | 76038 | France | Details | |
| Universitätsklinikum Ulm | Recruiting | Ulm | Baden-Württemberg | 89081 | Germany | Details |
| Uniklinik Köln | Recruiting | Kerpener | Köln | 50937 | Germany | Details |
| Gemeinschaftspraxis für Hämatologie and Onkologie | Not yet recruiting | Magdeburg | Sachsen-Anhalt | 39104 | Germany | Details |
| Onkologische Gemeinschaftspraxis / BAG | Recruiting | Dresden | Sachsen | 01307 | Germany | Details |
| Gemeinschaftspraxis für Hämatologie und Onkologie (Gefos) | Recruiting | Dortmund | 44309 | Germany | Details | |
| Universitaetsklinikum Carl Gustav Carus an der TU Dresden, Medizinische Klinik und Poliklinik 1 | Recruiting | Dresden | 01307 | Germany | Details | |
| Universitätsklinikum Tübingen Innere Medizin II | Recruiting | Tübingen | 72076 | Germany | Details | |
| Debreceni Egyetem Orvos-es Egészsegtudomanyi Centrum | Recruiting | Debrecen | 4032 | Hungary | Details | |
| SzSzB Megyei Korhazak es Egyetemi Oktatokorhaz | Recruiting | Nyiregyhaza | 4400 | Hungary | Details | |
| Markusovszky Egyetemi Oktatokorhaz | Recruiting | Szombathely | 9700 | Hungary | Details | |
| Rabin Medical Center | Not yet recruiting | Petah Tikva | HaMerkaz | 4941492 | Israel | Details |
| Hadassah Medical Center | Not yet recruiting | Jerusalem | 9112001 | Israel | Details | |
| Chaim Sheba Medical Center | Not yet recruiting | Ramat Gan | 5262100 | Israel | Details | |
| Azienda Unita Sanitaria Locale di Reggio Emilia | Recruiting | Reggio Emilia | Emilia-Romagna | 42122 | Italy | Details |
| Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori | Not yet recruiting | Meldola | Forlì-Cesena | 47014 | Italy | Details |
| Istituto di Candiolo IRCCS - Fondazione del Piemonte per l'Oncologia | Recruiting | Candiolo | Torino | 10060 | Italy | Details |
| Azienda Ospedaliera Nazionale Santi Antonio e Biagio e Cesare Arrigo | Recruiting | Alessandria | 15100 | Italy | Details | |
| Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico | Recruiting | Milano | 20122 | Italy | Details | |
| IRCCS Ospedale San Raffaele | Recruiting | Milano | 20132 | Italy | Details | |
| Istituto Europeo di Oncologia IRCCS | Not yet recruiting | Milano | 20141 | Italy | Details | |
| Azienda Ospedaliera Di Parma | Recruiting | Parma | 43126 | Italy | Details | |
| Ospedale Policlinico Giambattista Rossi, Borgo Roma | Not yet recruiting | Verona | 37134 | Italy | Details | |
| Tokai University Hospital- Isehara Campus | Recruiting | Isehara | Kanagawa | 259-1143 | Japan | Details |
| Kumamoto University Hospital | Recruiting | Kumamoto | 860-8556 | Japan | Details | |
| Yamagata University Hospital | Recruiting | Yamagata | 990-2331 | Japan | Details | |
| Seoul National University Hospital | Recruiting | Seoul | Seoul, Korea | 03080 | Korea, Republic of | Details |
| The Catholic University of Korea-Seoul St. Mary's Hospital | Recruiting | Seocho-Gu | Seoul | 06591 | Korea, Republic of | Details |
| Inje Univ Busan Paik Hospital | Recruiting | Busan | 47392 | Korea, Republic of | Details | |
| Samsung Medical Center | Recruiting | Seoul | 06351 | Korea, Republic of | Details | |
| Middlemore Clinical Trials | Recruiting | Papatoetoe | Auckland | 2025 | New Zealand | Details |
| P3 Research | Recruiting | Newtown | Wellington | 6021 | New Zealand | Details |
| Waikato Hospital | Not yet recruiting | Hamilton | 3204 | New Zealand | Details | |
| Wojewodzki Szpital Specjalistyczny | Recruiting | Iwaszkiewicza 5 | Legnica | 59-220 | Poland | Details |
| Uniwersyteckie Centrum Kliniczne | Recruiting | Gdansk | Pomorskie | 80214 | Poland | Details |
| Centrum Medyczne Pratia Poznan | Recruiting | Skorzewo | Poznan | 60 185 | Poland | Details |
| KO-MED Centra Kliniczne | Recruiting | Biała Podlaska | 21500 | Poland | Details | |
| Szpital Uniwersytecki nr 2 im. dr Jana Biziela w BydgoszczyKlinika Hematologii | Recruiting | Bydgoszcz | 85-168 | Poland | Details | |
| Pratia Onkologia Katowice | Recruiting | Katowice | 40-519 | Poland | Details | |
| PRATIA MCM Kraków | Recruiting | Kraków | 30-727 | Poland | Details | |
| Klinika Hematoonkologii i Transplantacji Szpiku,Samodzielny Publiczny Szpital Kliniczny Nr 1 | Recruiting | Lublin | 20-081 | Poland | Details | |
| Szpital Wojewodzki w Opolu | Recruiting | Opole | 45061 | Poland | Details | |
| Uniwersytecki Szpital Kliniczny Klinika | Recruiting | Wrocław | 50-367 | Poland | Details | |
| Institut Català d'Oncologia de Girona (ICO Girona) | Recruiting | Girona | Cataluna | 17007 | Spain | Details |
| Hospital Germans Trias i Pujol | Recruiting | Badalona | Catalunya [Cataluña] | 08916 | Spain | Details |
| Hospital Universitari Vall d'Hebron | Recruiting | Barcelona | Cataluña | 08035 | Spain | Details |
| Hospital Universitario Puerta de Hierro Majadahonda | Recruiting | Majadahonda | Madrid, Comunidad De | 28222 | Spain | Details |
| Hospital Costa Del Sol | Recruiting | Marbella | Malaga | 29603 | Spain | Details |
| Hospital De Navarra | Recruiting | Pamplona | Navarra | 31008 | Spain | Details |
| Hospital Clinic de Barcelona | Recruiting | Barcelona | 08036 | Spain | Details | |
| Hospital de la Santa Creu i Sant Pau | Recruiting | Barcelona | 08041 | Spain | Details | |
| Hospital Duran i Reynals | Recruiting | L'Hospitalet de Llobregat | 08908 | Spain | Details | |
| Hospital De Gran Canaria Dr. Negrin | Recruiting | Las Palmas de Gran Canaria | 35010 | Spain | Details | |
| Clinica Universitaria De Navarra | Recruiting | Madrid | 28027 | Spain | Details | |
| Hospital Universitario Infanta Leonor-INTERNAL MED | Recruiting | Madrid | 28031 | Spain | Details | |
| Hospital Universitario Ramón y Cajal | Recruiting | Madrid | Spain | Details | ||
| Hospital Universitario Marqués de Valdecilla | Recruiting | Santander | 39008 | Spain | Details | |
| Hospital Universitario Virgen Macarena | Recruiting | Sevilla | 41009 | Spain | Details | |
| Hospital Universitario Virgen Del Rocio | Recruiting | Sevilla | 41013 | Spain | Details | |
| Chang Gung Memorial Hospital - Chiayi | Recruiting | Putz | Chiayi Hsien | 61363 | Taiwan | Details |
| Chang Bing Show Chwan Memorial Hospital | Recruiting | Changhua | 50544 | Taiwan | Details | |
| National Cheng Kung University Hospital | Recruiting | Tainan | 704 | Taiwan | Details | |
| Koo Foundation Sun Yan-Sen Cancer Center | Recruiting | Taipei | 11259 | Taiwan | Details | |
| Ankara University Medicine Hospital | Recruiting | Mamak | Ankara | Turkey | Details | |
| Istanbul University Istanbul Medicine Faculty | Recruiting | Faith | Istanbul | Turkey | Details | |
| Acıbadem Maslak Hastanesi | Recruiting | Sarıyer | İstanbul | 34457 | Turkey | Details |
| 9 Eylul University Hospital | Recruiting | Balçova | İzmir | 35100 | Turkey | Details |
| Ege Üniversitesi | Recruiting | Bornova | Izmir | 35040 | Turkey | Details |
| Gazi University Faculty of Medicine | Recruiting | Ankara | Yenimahalle | 06560 | Turkey | Details |
| American Hospital | Recruiting | Istanbul | Turkey | Details | ||
| Bristol Haematology and Oncology Centre | Not yet recruiting | Bristol | Bristol, City Of | BS2 8ED | United Kingdom | Details |
| Castle Hill Hospital | Recruiting | Cottingham | East Yorkshire | HU16 5JQ | United Kingdom | Details |
| St Bartholomew's Hospital | Recruiting | London | London, City Of | EC1A 7BE | United Kingdom | Details |
| City Hospital, Nottingham University Hospitals | Recruiting | Nottingham | Nottinghamshire | NG5 1PB | United Kingdom | Details |
| Sunderland Royal Hospital | Recruiting | Sunderland | Tyne And Wear | SR4 7TP | United Kingdom | Details |
| HOPE Centre | Recruiting | Leicester | LE1 5WW | United Kingdom | Details | |
| Singleton Hospital | Recruiting | Swansea | SA2 8QA | United Kingdom | Details |