Disease Detail

ID DOID:3284
Name thymic carcinoma
Definition A thymus cancer that derives_from epithelial cells. The tumor cells in a thymic carcinoma look very different from the normal cells of the thymus, grow more quickly, and have usually spread to other parts of the body when the cancer is found.
Source DiseaseOntology.org
Alt Ids
Path disease disease of cellular proliferation cancer organ system cancer immune system cancer thymus cancer thymic carcinoma

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
KIT D579del Imatinib thymic carcinoma sensitive detail...
KIT Y553N Imatinib thymic carcinoma sensitive detail...
KIT V560del KIT over exp Imatinib thymic carcinoma predicted - sensitive detail...
KIT P577_D579del Sorafenib thymic carcinoma predicted - sensitive detail...
KIT D820E Sorafenib thymic carcinoma predicted - sensitive detail...
Unknown unknown Selinexor thymic carcinoma not applicable detail...
Unknown unknown Bevacizumab + MINT1526A thymic carcinoma not applicable detail...
Clinical Trial Phase Therapies Title Recruitment Status
NCT01011439 Phase II Milciclib Phase II Study Of Oral PHA-848125AC In Patients With Thymic Carcinoma Terminated
NCT01025089 Phase II Cetuximab Cisplatin + Cyclophosphamide + Doxorubicin Chemotherapy Plus Cetuximab Followed by Surgical Resection in Patients With Locally Advanced or Recurrent Thymoma or Thymic Carcinoma Active, not recruiting
NCT01301391 Phase II Milciclib Study Of Oral PHA-848125AC In Patients With Malignant Thymoma Previously Treated With Multiple Lines Of Chemotherapy Terminated
NCT01396408 Phase II Temsirolimus Sunitinib A Phase II Study of Sunitinib or Temsirolimus in Patients With Advanced Rare Tumours Active, not recruiting
NCT01621568 Phase II Sunitinib Sunitinib for Advanced Thymus Cancer Following Earlier Treatment Active, not recruiting
NCT02364076 Phase II Pembrolizumab MK-3475 in Patients With Thymic Carcinoma Active, not recruiting
NCT02824042 Phase I Anetumab ravtansine + Itraconazole Anetumab ravtansine Thorough ECG (Electrocardiogram) and Drug Interaction Study With Anetumab Ravtansine and Itraconazole Active, not recruiting
NCT03076554 Phase II Avelumab A Pilot Study to Investigate the Safety and Clinical Activity of Avelumab (MSB0010718C) in Thymoma and Thymic Carcinoma After Progression on Platinum-Based Chemotherapy Recruiting
NCT03193437 Phase II Selinexor Selinexor in Patients With Advanced Thymic Epithelial Tumor Progressing After Primary Chemotherapy Recruiting
NCT03295227 Phase I Pembrolizumab Feasibility Trial of Pembrolizumab in Unresectable Thymoma and Thymic Carcinoma Recruiting
NCT03463460 Phase II Pembrolizumab + Sunitinib Pembrolizumab and Sunitinib Malate in Treating Participants With Refractory Metastatic or Unresectable Thymic Cancer Recruiting
NCT03583086 Phase Ib/II Nivolumab + Vorolanib H I/II Eval Safety & Prelim Activity Nivolumab Comb W/Vorolanib Pts W/Refractory Thoracic Tumors Recruiting
NCT03694002 Phase II Carboplatin + Paclitaxel Carboplatin + Paclitaxel + Ramucirumab Carboplatin and Paclitaxel With or Without Ramucirumab in Treating Patients With Locally Advanced, Recurrent, or Metastatic Thymic Cancer That Cannot Be Removed by Surgery Recruiting