Disease Detail

ID DOID:3355
Name fibrosarcoma
Definition A connective tissue cancer that has_material_basis_in fibrous connective tissue and characterized by the presence of immature proliferating fibroblasts or undifferentiated anaplastic spindle cells in a storiform pattern.
Source DiseaseOntology.org
Alt Ids DOID:3509 DOID:156
Path disease disease of cellular proliferation cancer organ system cancer musculoskeletal system cancer connective tissue cancer fibrosarcoma

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
Unknown unknown ABT-348 fibrosarcoma not applicable detail...
Unknown unknown Anlotinib fibrosarcoma not applicable detail...
Unknown unknown 23814 fibrosarcoma not applicable detail...
Unknown unknown Tivozanib fibrosarcoma not applicable detail...
Unknown unknown 23814 + Tivozanib fibrosarcoma not applicable detail...
TP53 wild-type Pegylated liposomal-doxorubicin + RO6839921 fibrosarcoma sensitive detail...
IDH1 R132C AG-881 fibrosarcoma predicted - sensitive detail...
ETV6-NTRK3 Entrectinib fibrosarcoma predicted - sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status
NCT00356031 Phase II Bevacizumab Bevacizumab and Radiation Therapy for Sarcomas Completed
NCT01981551 Phase II PF-03084014 Phase II Trial of the Gamma-Secretase Inhibitor PF-03084014 in Adults With Desmoid Tumors/Aggressive Fibromatosis Active, not recruiting
NCT02584309 Phase II Dexrazoxane Doxorubicin + Olaratumab Doxorubicin With Upfront Dexrazoxane Plus Olaratumab for the Treatment of Advanced or Metastatic Soft Tissue Sarcoma Recruiting
NCT02923778 Phase II Talimogene laherparepvec Talimogene Laherparepvec and Radiation Therapy in Treating Patients With Newly Diagnosed Soft Tissue Sarcoma That Can Be Removed by Surgery Recruiting
NCT03009201 Phase I Doxorubicin + Ribociclib Ribociclib and Doxorubicin Hydrochloride in Treating Patients Metastatic or Advanced Soft Tissue Sarcomas That Cannot Be Removed by Surgery Recruiting
NCT03092323 Phase II Pembrolizumab A Randomized Trial of Pembrolizumab & Radiotherapy Versus Radiotherapy in High-Risk Soft Tissue Sarcoma of the Extremity (SU2C-SARC032) Recruiting