Disease Detail


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ID DOID:3371
Name chondrosarcoma
Definition A bone sarcoma that has_material_basis_in cells derived from transformed cells that produce cartilage.
Source DiseaseOntology.org
Alt Ids DOID:3370
Path disease disease of cellular proliferation cancer organ system cancer musculoskeletal system cancer connective tissue cancer bone cancer bone sarcoma chondrosarcoma


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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
IDH1 mutant Dasatinib chondrosarcoma resistant detail...
IDH1 R132C Ivosidenib chondrosarcoma predicted - sensitive detail...
IDH1 R132G Ivosidenib chondrosarcoma predicted - sensitive detail...
IDH1 R132L Ivosidenib chondrosarcoma predicted - sensitive detail...
IDH1 R132S Ivosidenib chondrosarcoma predicted - sensitive detail...
IDH1 act mut Ivosidenib chondrosarcoma sensitive detail...
MLH1 negative Pembrolizumab chondrosarcoma sensitive detail...
MSH6 negative Pembrolizumab chondrosarcoma sensitive detail...
IDH1 R132S Olaparib chondrosarcoma predicted - sensitive detail...
IDH1 R132C Olaparib chondrosarcoma predicted - sensitive detail...
IDH2 R172S Ceralasertib + Olaparib chondrosarcoma sensitive detail...
IDH1 act mut Olutasidenib chondrosarcoma predicted - sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT01446809 Phase I Doxorubicin + Ifosfamide Doxorubicin + Ifosfamide + Pazopanib Pazopanib Hydrochloride Followed By Chemotherapy and Surgery in Treating Patients With Soft Tissue Sarcoma Completed USA 0
NCT02389244 Phase II Regorafenib A Phase II Study Evaluating Efficacy and Safety of Regorafenib in Patients With Metastatic Bone Sarcomas (REGOBONE) Recruiting FRA 0
NCT03190174 Phase Ib/II Nab-rapamycin + Nivolumab Nivolumab (Opdivo) Plus ABI-009 (Nab-rapamycin) for Advanced Sarcoma Completed USA 0
NCT03277924 Phase Ib/II Nivolumab + Sunitinib Trial of Sunitinib Plus Nivolumab After Standard Treatment in Advanced Soft Tissue and Bone Sarcomas (ImmunoSarc) Recruiting ITA | GBR | ESP 0
NCT03282344 Phase II Nivolumab + NKTR-214 A Study of NKTR-214 in Combination With Nivolumab in Patients With Metastatic and/or Locally Advanced Sarcoma Active, not recruiting USA 0
NCT03684811 Phase Ib/II Cisplatin + Gemcitabine + Olutasidenib Azacitidine + Olutasidenib Olutasidenib Nivolumab + Olutasidenib A Study of FT-2102 in Patients With Advanced Solid Tumors and Gliomas With an IDH1 Mutation Completed USA | GBR | FRA | ESP | AUS 1
NCT04040205 Phase II Abemaciclib Abemaciclib for Bone and Soft Tissue Sarcoma With Cyclin-Dependent Kinase (CDK) Pathway Alteration Recruiting USA 0
NCT04205227 Phase Ib/II ENB003 + Pembrolizumab ENB003 Plus Pembrolizumab Phase 1b/2a in Solid Tumors Active, not recruiting USA | AUS 0
NCT04278781 Phase II Ivosidenib AG-120 in People With IDH1 Mutant Chondrosarcoma Recruiting USA 0
NCT04340843 Phase II Belinostat + Guadecitabine Testing the Combination of Belinostat and SGI-110 (Guadecitabine) for the Treatment of Unresectable and Metastatic Conventional Chondrosarcoma Suspended USA 0
NCT04458922 Phase II Atezolizumab Testing Atezolizumab in People With Clear Cell Sarcoma or Advanced Chondrosarcoma Active, not recruiting USA | CAN 0
NCT04521686 Phase I LY3410738 Study of LY3410738 Administered to Patients With Advanced Solid Tumors With IDH1 or IDH2 Mutations Active, not recruiting USA | FRA | ESP | AUS 5
NCT04784247 Phase II Lenvatinib + Pembrolizumab Lenvatinib and Pembrolizumab in People With Advanced Soft Tissue Sarcoma Recruiting USA 0
NCT04950075 Phase II INBRX-109 Study of INBRX-109 in Conventional Chondrosarcoma Recruiting USA | ITA | GBR | FRA | ESP | DEU | AUS 4
NCT05039801 Phase I Bevacizumab + IACS-6274 + Paclitaxel IACS-6274 IACS-6274 With or Without Bevacizumab and Paclitaxel for the Treatment of Advanced Solid Tumors Recruiting USA 0
NCT05131386 Phase II Dexamethasone + Trabectedin Multicohort Trial of Trabectedin and Low-dose Radiation Therapy in Advanced/Metastatic Sarcomas (SYNERGIAS) Recruiting ESP 0
NCT05389462 Phase I ADCT-601 + Gemcitabine ADCT-601 A Study of Mipasetamab Uzoptirine (ADCT-601) in Participants With Solid Tumors Recruiting USA | FRA | ESP 0