Disease Detail

ID DOID:4465
Name papillary renal cell carcinoma
Definition A renal cell carcinoma that is characterized by the development of multiple, bilateral papillary renal tumors.
Source DiseaseOntology.org
Alt Ids DOID:8063
Path disease disease of cellular proliferation cancer organ system cancer urinary system cancer kidney cancer renal carcinoma renal cell carcinoma papillary renal cell carcinoma


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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
MET amp Savolitinib papillary renal cell carcinoma sensitive detail...
Unknown unknown Bevacizumab + Everolimus papillary renal cell carcinoma not applicable detail...
Unknown unknown Abexinostat + Pazopanib papillary renal cell carcinoma not applicable detail...
MET act mut Savolitinib papillary renal cell carcinoma predicted - sensitive detail...
MET M1149T Crizotinib papillary renal cell carcinoma predicted - sensitive detail...
MET F1200I Crizotinib papillary renal cell carcinoma predicted - sensitive detail...
MET D1228H Crizotinib papillary renal cell carcinoma predicted - sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status
NCT00831480 Phase II Everolimus Everolimus(RAD001) For Advanced Renal Cell Carcinoma(RCC)Before Kidney Removal Terminated
NCT01130519 Phase II Bevacizumab + Erlotinib A Phase II Study of Bevacizumab and Erlotinib in Subjects With Advanced Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) or Sporadic Papillary Renal Cell Cancer Recruiting
NCT02019693 Phase II Capmatinib A Phase 2 Study of the MET Kinase Inhibitor INC280 in Papillary Renal Cell Cancer Recruiting
NCT02127710 Phase II Savolitinib A Phase II Trial to Evaluate the Efficacy of AZD6094 (HMPL-504) in Patients With Papillary Renal Cell Carcinoma (PRCC) Active, not recruiting
NCT02761057 Phase II Savolitinib Cabozantinib Crizotinib Sunitinib Cabozantinib-S-Malate, Crizotinib, Volitinib, or Sunitinib Malate in Treating Patients With Locally Advanced or Metastatic Kidney Cancer Recruiting
NCT02837991 Phase Ib/II CDX-014 A Dose Escalation, Safety and Activity Study of CDX-014 in Patients With Advanced or Metastatic Renal Cell Carcinoma Terminated
NCT02915783 Phase II Everolimus + Lenvatinib A Phase 2 Trial to Evaluate Efficacy and Safety of Lenvatinib in Combination With Everolimus in Subjects With Unresectable Advanced or Metastatic Non Clear Cell Renal Cell Carcinoma (nccRCC) Who Have Not Received Any Chemotherapy for Advanced Disease Active, not recruiting
NCT03091192 Phase III Sunitinib Savolitinib Savolitinib vs. Sunitinib in MET-driven PRCC Active, not recruiting
NCT03319628 Phase I XMT-1536 First-in-Human Study of XMT-1536 in Cancers Likely to Express NaPi2b Recruiting
NCT03541902 Phase II Cabozantinib Sunitinib Cabozantinib Versus Sunitinib for Metastatic Variant Histology Renal Cell Carcinoma Recruiting
NCT03866382 Phase II Cabozantinib + Nivolumab Cabozantinib + Ipilimumab + Nivolumab Cabozantinib in Combination With Nivolumab and Ipilimumab in Rare Genitourinary Tumors Recruiting