Disease Detail

ID DOID:5015
Name fibrolamellar carcinoma
Definition A hepatocellular carcinoma characterized microscopically by laminated fibrous layers interspersed between the tumour cells. The polygonal, deeply eosinophilic tumor cells arise in non-cirrhotic livers.
Source DiseaseOntology.org
Alt Ids
Path disease disease of cellular proliferation cancer organ system cancer gastrointestinal system cancer liver cancer liver carcinoma hepatocellular carcinoma fibrolamellar carcinoma

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
FBXW7 inact mut Sirolimus fibrolamellar carcinoma sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status
NCT01396408 Phase II Temsirolimus Sunitinib A Phase II Study of Sunitinib or Temsirolimus in Patients With Advanced Rare Tumours Active, not recruiting
NCT02234986 Phase II ENMD-2076 A Multi-center, Open-label Study of Oral ENMD-2076 for the Treatment of Patients With Advanced Fibrolamellar Carcinoma Completed