Disease Detail


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ID DOID:50921
Name pharynx squamous cell carcinoma
Definition A pharynx cancer that has_material_basis_in squamous cells.
Source DiseaseOntology.org
Alt Ids
Path disease disease of cellular proliferation cancer organ system cancer gastrointestinal system cancer pharynx cancer pharynx squamous cell carcinoma


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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
TP53 mutant Ceralasertib + Radiotherapy pharynx squamous cell carcinoma sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT01540682 Phase I Alisertib + Cetuximab MLN8237 in Head and Neck Cancer Completed USA 0
NCT03247309 Phase I Aldesleukin + IMA201 Cyclophosphamide + Fludarabine TCR-engineered T Cells in Solid Tumors With Emphasis on NSCLC and HNSCC (ACTengine) (ACTengine) Completed USA | DEU 0
NCT03258008 Phase II ISA101b + Utomilumab Utomilumab and ISA101b Vaccination in Patients With HPV-16-Positive Incurable Oropharyngeal Cancer Terminated USA 0
NCT03383094 Phase II Pembrolizumab Cisplatin + Radiotherapy Chemoradiation vs Immunotherapy and Radiation for Head and Neck Cancer Recruiting USA 0
NCT03539198 Phase 0 Nivolumab Study of Proton SBRT and Immunotherapy for Recurrent/Progressive Locoregional or Metastatic Head and Neck Cancer Terminated USA 0
NCT03601507 Phase II Alpelisib Alpelisib in Treating Participants With Transorally Resectable HPV-Associated Stage I-IVA Oropharyngeal Cancer Terminated USA 0
NCT03618134 Phase Ib/II Durvalumab Durvalumab + Tremelimumab Stereotactic Body Radiation Therapy and Durvalumab With or Without Tremelimumab Before Surgery in Treating Participants With Human Papillomavirus Positive Oropharyngeal Squamous Cell Caner Terminated USA 0
NCT03719690 Phase II Tipifarnib Safety and Efficacy of Tipifarnib in Head and Neck Cancer With HRAS Mutations and Impact of HRAS on Response to Therapy (AIM-HN/SEQ-HN) Completed USA | NLD | ITA | GBR | ESP | DEU | BEL | AUT | AUS 7
NCT03906526 Phase I Motolimod Motolimod + Nivolumab Nivolumab A Study to Evaluate Immune Biomarker Modulation in Response to VTX-2337 in Combination With an Anti- PD-1 Inhibitor in Head and Neck Cancer Terminated USA 0
NCT03944915 Phase II Carboplatin + Nivolumab + Paclitaxel Cisplatin + Filgrastim + Fluorouracil + Hydroxyurea + Paclitaxel De-Escalation Therapy for Human Papillomavirus Negative Disease (DEPEND) Recruiting USA 0
NCT04106362 Phase II Cisplatin Cetuximab + Cisplatin Radiation Therapy and Cisplatin With or Without Cetuximab in Treating Patients With HPV Positive, KRAS-Variant Stage III-IV Oropharyngeal Squamous Cell Carcinoma Terminated USA 0
NCT04754321 Phase I Pembrolizumab Pembrolizumab and Radiation Therapy Before and During Surgery for the Treatment of Persistent or Recurrent Head and Neck Cancer Recruiting USA 0
NCT04892875 Phase I Cisplatin + Zimberelimab Cisplatin Cisplatin + Etrumadenant + Zimberelimab A Study of Concurrent Chemoradiation in Combination With or Without PD1 Inhibitor AB122 Adenosine 2a Receptor / Adenosine 2b Receptor Inhibitor AB928 Therapies in Locally Advanced Head and Neck Cancers (PANTHEoN) Withdrawn 0
NCT05608369 Phase II Cisplatin Cisplatin + Vorinostat Vorinostat in Combination With Chemoradiation in Locally Advanced HPV Negative HNSCC (HPV) Not yet recruiting USA 0
NCT05743270 Phase II Cisplatin Nivolumab Cisplatin + RP3 Carboplatin + Paclitaxel + RP3 Study of RP3 in Combination With Nivolumab and Other Therapy in Patients With Locoregionally Advanced or Recurrent SCCHN Withdrawn USA | GBR | FRA | ESP | DEU 3
NCT05814666 Phase II Pembrolizumab Danvatirsen + Pembrolizumab Activity and Safety of Danvatirsen and Pembrolizumab in HNSCC (PEMDA-HN) Recruiting USA 1
NCT05879484 Phase Ib/II DS-3201b + Pembrolizumab Study of Front Line Pembrolizumab and Valemetostat in PD-L1 Positive, HPV-Negative Recurrent/Metastatic Squamous Cell Carcinoma (SCC) of the Head and Neck: The PANTHERAS Not yet recruiting USA 0
NCT05909904 Phase II LBL-007 + Tislelizumab Tislelizumab BGB-A425 + Tislelizumab BGB-A425 + LBL-007 + Tislelizumab Tislelizumab in Combination With Investigational Agents in Participants With Head and Neck Squamous Cell Carcinoma Recruiting USA | ITA | GBR | FRA | ESP | CAN | AUS 7
NCT05980000 Phase II Pembrolizumab + Ramucirumab Pembrolizumab Ramucirumab and Pembrolizumab vs Pembrolizumab Monotherapy in PD-L1 Positive Head and Neck Squamous-Cell Carcinoma (Rambro2) Recruiting USA 0
NCT06332092 Phase II Cetuximab + FID-007 FID-007 and Cetuximab in Treating Patients With Advanced Head and Neck Squamous Cell Carcinoma (HNSCC) Recruiting USA 0