Disease Detail


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ID DOID:80525
Name differentiated thyroid gland carcinoma
Definition A thyroid gland adenocarcinoma characterized by extensive evidence of follicular cell differentiation.
Source DiseaseOntology.org
Alt Ids
Path disease disease of cellular proliferation cancer organ system cancer endocrine gland cancer thyroid cancer thyroid gland carcinoma thyroid gland adenocarcinoma differentiated thyroid gland carcinoma


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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
NRAS mutant Pazopanib + Trametinib differentiated thyroid gland carcinoma predicted - sensitive detail...
RET fusion Selpercatinib differentiated thyroid gland carcinoma sensitive detail...
RET fusion Pralsetinib differentiated thyroid gland carcinoma sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03475953 Phase Ib/II Avelumab + Regorafenib A Phase I/II Study of Regorafenib Plus Avelumab in Solid Tumors (REGOMUNE) Recruiting FRA 0
NCT03732495 Phase II Denosumab + Lenvatinib Study of the Efficacy of Lenvatinib Combined With Denosumab in the Treatment of Patients With Predominant Bone Metastatic Radioiodine Refractory Differentiated Thyroid Carcinomas (LENVOS) Unknown status FRA 0
NCT03753919 Phase II Durvalumab + Tremelimumab Durvalumab Plus Tremelimumab for the Treatment of Patients With Progressive, Refractory Advanced Thyroid Carcinoma -The DUTHY Trial (DUTHY) Active, not recruiting ESP 0
NCT04514484 Phase I Cabozantinib + Nivolumab Testing the Combination of the Anti-cancer Drugs XL184 (Cabozantinib) and Nivolumab in Patients With Advanced Cancer and HIV Active, not recruiting USA 0
NCT04544111 Phase II Dabrafenib + Spartalizumab Spartalizumab + Trametinib PDR001 Combination Therapy for Radioiodine-Refractory Thyroid Cancer Active, not recruiting USA 0
NCT05783323 Phase II Larotrectinib Larotrectinib to Enhance RAI Avidity in Differentiated Thyroid Cancer Recruiting USA 0
NCT06007924 Phase II Defactinib + RO5126766 A Study of Avutometinib and Defactinib in People With Thyroid Cancer Recruiting USA 0
NCT06235216 Phase II Sacituzumab govitecan-hziy Sacituzumab govitEcan in THYroid Cancers (SETHY) Not yet recruiting ESP 0