Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name THOR-707
Trade Name
Synonyms THOR707|THOR 707|SAR444245|SAR-444245|SAR 444245
Drug Descriptions

THOR-707 is a pegylated recombinant version of IL-2 that binds IL2beta, but does not bind to IL-2 alpha, potentially resulting in activation and tumor infiltration of CD8-positive T cells without proliferation of CD4-positive immune cells (Annals of Oncology (2019) 30 (suppl_5): v475-v532).

CAS Registry Number NA
NCIT ID C162645


  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")


  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Carboplatin + Pembrolizumab + Pemetrexed Disodium + THOR-707 Carboplatin Pembrolizumab Pemetrexed Disodium THOR-707 0 1
Cemiplimab + THOR-707 Cemiplimab THOR-707 0 2
Cetuximab + Pembrolizumab + THOR-707 Cetuximab Pembrolizumab THOR-707 0 1
Cetuximab + THOR-707 Cetuximab THOR-707 0 2
Cisplatin + Pembrolizumab + Pemetrexed Disodium + THOR-707 Cisplatin Pembrolizumab Pemetrexed Disodium THOR-707 0 1
Nab-paclitaxel + Pembrolizumab + THOR-707 Nab-paclitaxel Pembrolizumab THOR-707 0 1
Pembrolizumab + THOR-707 Pembrolizumab THOR-707 0 4
THOR-707 THOR-707 0 2
THOR-707 + unspecified CTLA4 antibody THOR-707 unspecified CTLA4 antibody 0 1
THOR-707 + unspecified PD-1 antibody THOR-707 unspecified PD-1 antibody 0 1
THOR-707 + unspecified PD-L1 antibody THOR-707 unspecified PD-L1 antibody 0 1

Additional content available in CKB BOOST