Drug Detail


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Drug Name THOR-707
Trade Name
Synonyms THOR707|THOR 707|SAR444245|SAR-444245|SAR 444245
Drug Descriptions

THOR-707 is a pegylated recombinant version of IL-2 that binds IL2beta, but does not bind to IL-2 alpha, potentially resulting in activation and tumor infiltration of CD8-positive T cells without proliferation of CD4-positive immune cells (Annals of Oncology (2019) 30 (suppl_5): v475-v532).

CAS Registry Number NA
NCIT ID C162645


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Carboplatin + Pembrolizumab + Pemetrexed Disodium + THOR-707 Carboplatin Pembrolizumab Pemetrexed Disodium THOR-707 0 1
Cemiplimab + THOR-707 Cemiplimab THOR-707 0 1
Cetuximab + Pembrolizumab + THOR-707 Cetuximab Pembrolizumab THOR-707 0 1
Cetuximab + THOR-707 Cetuximab THOR-707 0 2
Cisplatin + Pembrolizumab + Pemetrexed Disodium + THOR-707 Cisplatin Pembrolizumab Pemetrexed Disodium THOR-707 0 1
Nab-paclitaxel + Pembrolizumab + THOR-707 Nab-paclitaxel Pembrolizumab THOR-707 0 1
Pembrolizumab + THOR-707 Pembrolizumab THOR-707 0 4
THOR-707 THOR-707 0 2
THOR-707 + unspecified CTLA4 antibody THOR-707 unspecified CTLA4 antibody 0 1
THOR-707 + unspecified PD-1 antibody THOR-707 unspecified PD-1 antibody 0 1
THOR-707 + unspecified PD-L1 antibody THOR-707 unspecified PD-L1 antibody 0 1

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