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Drug Name | ADC ST8176AA1 |
Trade Name | |
Synonyms | Trastuzumab-HDACi ST8176AA1|ST8176AA1 ADC|ST8176AA1-ADC |
Drug Descriptions |
ADC ST8176AA1 is an antibody-drug conjugate (ADC) comprising Herceptin (trastuzumab), an ERBB2 (HER2) antibody, linked to ST7464AA1, which delivers the HDAC inhibitor to tumor cells expressing ERBB2 (HER2), potentially inhibiting Erbb2 signaling, and resulting in increased DNA damage and apoptosis, and reduced cell proliferation and tumor growth (PMID: 32039017). |
DrugClasses | HER2 (ERBB2) Antibody 72 HER2 (ERBB2) Antibody-Drug Conjugate 27 |
CAS Registry Number | NA |
NCIT ID | NA |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
ADC ST8176AA1 | ADC ST8176AA1 | 0 | 0 |