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|Drug Name||GLYCAR T cells|
|Synonyms||GPC3 CAR T cells|CAR-GPC3 T Cells|Glypican-3 CAR T Cells|
GLYCAR T cells consist of a preparation of autologous peripheral blood mononuclear cells engineered to express a chimeric antigen receptor (CAR) targeting GPC3 linked to CD8 alpha hinge domain, CD28 transmembrane domain, and CD3zeta signaling domain, which may lead to antitumor activity, including reduced tumor growth in GPC3-positive tumor cells (PMID: 32371538).
|CAS Registry Number||NA|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|GLYCAR T cells||GLYCAR T cells||0||1|
|GLYCAR T cells + Sorafenib||GLYCAR T cells Sorafenib||0||0|