Drug Detail


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Drug Name M6223
Trade Name
Synonyms M-6223|M 6223
Drug Descriptions

M6223 targets and binds to TIGIT on immune cells, including tumor-infiltrating lymphocytes, and prevents its interaction with CD112 and CD155, thereby leading to enhanced interaction of CD112 and CD155 with CD226 expressed on natural killer and CD8 T+ cells, which may lead to the activation of anti-tumor immune responses (NCI Drug Dictionary).

CAS Registry Number NA
NCIT ID C173891


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Avelumab + M6223 Avelumab M6223 0 1
Bintrafusp alfa + M6223 Bintrafusp alfa M6223 0 1
M6223 M6223 0 1

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