Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name DSP107
Trade Name
Synonyms DSP-107|DSP 107|SIRPa-4-1BBL DSP107|SIRPa 4-1BBL DSP107
Drug Descriptions

DSP107 is a bi-functional trimeric fusion protein that consists of extracellular domains of SIRP alpha and 4-1BBL, which blocks the interaction between CD47 and SIRP alpha, and simultaneously activates the co-stimulatory receptor 4-1BB, potentially activating innate and adaptive immune responses, and inducing cytotoxicity and phagocytosis of tumor cells (Cancer Immunol Res 2019;7(2 Suppl):Abstract nr A076; Blood (2020) 136 (Supplement 1): 19-20).

CAS Registry Number NA
NCIT ID C174171


  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")


  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Atezolizumab + DSP107 Atezolizumab DSP107 0 1
Azacitidine + DSP107 + Venetoclax Azacitidine DSP107 Venetoclax 0 1
Cetuximab + DSP107 Cetuximab DSP107 0 0
DSP107 DSP107 0 1
DSP107 + Rituximab DSP107 Rituximab 0 0

Additional content available in CKB BOOST