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Drug Name DSP107
Trade Name
Synonyms DSP-107|DSP 107|SIRPa-4-1BBL DSP107|SIRPa 4-1BBL DSP107
Drug Descriptions

DSP107 is a bi-functional trimeric fusion protein that consists of extracellular domains of SIRP alpha and 4-1BBL, which blocks the interaction between CD47 and SIRP alpha, and simultaneously activates the co-stimulatory receptor 4-1BB, potentially activating innate and adaptive immune responses, and inducing cytotoxicity and phagocytosis of tumor cells (Cancer Immunol Res 2019;7(2 Suppl):Abstract nr A076; Blood (2020) 136 (Supplement 1): 19-20).

DrugClasses
CAS Registry Number NA
NCIT ID C174171

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Atezolizumab + DSP107 Atezolizumab DSP107 0 1
Cetuximab + DSP107 Cetuximab DSP107 0 0
DSP107 DSP107 0 1
DSP107 + Rituximab DSP107 Rituximab 0 0


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