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|Synonyms||ALPN 202|ALPN202|CD80 vIgD-Fc Fusion Protein ALPN-202|
ALPN-202 is a fusion protein consisting of the N-terminal Ig variable-like (IgV) domain of CD80 fused to an immunoglobulin G1 (IgG1) Fc fragment that inhibits programmed cell death-1 ligand 1 (PD-L1; CD274) and CTL-associated antigen 4 (CTLA4) signaling and activates PD-L1-dependent CD28 signaling, which potentially leads to immune checkpoint inhibition and increased antitumor immune response (J Clin Oncol 39, no. 15_suppl (May 20, 2021) 2547-2547).
|DrugClasses||CTLA4 Inhibitor 4 Immune Checkpoint Inhibitor 146 PD-L1 Inhibitor 13|
|CAS Registry Number||NA|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|ALPN-202 + unspecified PD-1 antibody||ALPN-202 unspecified PD-1 antibody||0||1|