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Drug Name ALPN-202
Trade Name
Synonyms ALPN 202|ALPN202|CD80 vIgD-Fc Fusion Protein ALPN-202
Drug Descriptions

ALPN-202 is a fusion protein consisting of the N-terminal Ig variable-like (IgV) domain of CD80 fused to an immunoglobulin G1 (IgG1) Fc fragment that inhibits programmed cell death-1 ligand 1 (PD-L1; CD274) and CTL-associated antigen 4 (CTLA4) signaling and activates PD-L1-dependent CD28 signaling, which potentially leads to immune checkpoint inhibition and increased antitumor immune response (J Clin Oncol 39, no. 15_suppl (May 20, 2021) 2547-2547).

DrugClasses CTLA4 Inhibitor 3 Immune Checkpoint Inhibitor 149 PD-L1 Inhibitor 11
CAS Registry Number NA
NCIT ID C174515

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Therapy Name Drugs Efficacy Evidence Clinical Trials
ALPN-202 ALPN-202 0 1
ALPN-202 + unspecified PD-1 antibody ALPN-202 unspecified PD-1 antibody 0 1


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