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Drug Name DS-1594b
Trade Name
Synonyms DS 1594b|DS1594b
Drug Descriptions

DS-1594b is a menin inhibitor that blocks the interaction of menin with MLL (KMT2A), leading to decreased expression of target genes, potentially resulting in reduced cell proliferation of leukemic cells harboring MLL rearrangements (NCI Drug Dictionary).

DrugClasses MEN1-KMT2A Inhibitor 5
CAS Registry Number NA
NCIT ID C179693

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Azacitidine + DS-1594b + Venetoclax Azacitidine DS-1594b Venetoclax 0 1
Cyclophosphamide + Cytarabine + Dexamethasone + DS-1594b + Filgrastim + Mesna + Methotrexate + Vincristine Sulfate Cyclophosphamide Cytarabine DS-1594b Dexamethasone Filgrastim Mesna Methotrexate Vincristine Sulfate 0 1
Cytarabine + DS-1594b + Filgrastim + Leucovorin + Methotrexate Cytarabine DS-1594b Filgrastim Leucovorin Methotrexate 0 1
Cytarabine + DS-1594b + Filgrastim + Leucovorin + Methotrexate + Rituximab Cytarabine DS-1594b Filgrastim Leucovorin Methotrexate Rituximab 0 1
DS-1594b DS-1594b 0 1
DS-1594b + Prednisone + Vincristine Sulfate DS-1594b Prednisone Vincristine Sulfate 0 1


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