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Drug Name Epcoritamab-bysp
Trade Name Epkinly
Synonyms DuoBody-CD3xCD20|GEN 3013|GEN-3013|GEN3013
Drug Descriptions

Epkinly (epcoritamab-bysp) is a bispecific antibody that targets CD3 and CD20, resulting in T-cell activation and redirection of T-cells to CD20-expressing tumor cells, which may lead to tumor cell cytotoxicity and inhibition of tumor growth (PMID: 31981978, PMID: 33602901). Epkinly (epcoritamab-bysp) is FDA-approved for use in patients with relapsed or refractory diffuse large B-cell lymphoma and high-grade B-cell lymphoma after two or more lines of systemic therapy (FDA.gov).

DrugClasses CD20 Antibody 18 CD3 Antibody 78
CAS Registry Number 2134641-34-0
NCIT ID C163022

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bendamustine + Epcoritamab-bysp + Rituximab Bendamustine Epcoritamab-bysp Rituximab 0 1
Cisplatin + Cytarabine + Dexamethasone + Epcoritamab-bysp + Rituximab Cisplatin Cytarabine Dexamethasone Epcoritamab-bysp Rituximab 0 1
Cyclophosphamide + Doxorubicin + Epcoritamab-bysp + Polatuzumab vedotin-piiq + Prednisone + Rituximab Cyclophosphamide Doxorubicin Epcoritamab-bysp Polatuzumab vedotin-piiq Prednisone Rituximab 0 1
Cyclophosphamide + Doxorubicin + Epcoritamab-bysp + Prednisone + Rituximab + Vincristine Sulfate Cyclophosphamide Doxorubicin Epcoritamab-bysp Prednisone Rituximab Vincristine Sulfate 0 2
Epcoritamab-bysp Epcoritamab-bysp 0 6
Epcoritamab-bysp + Gemcitabine + Oxaliplatin Epcoritamab-bysp Gemcitabine Oxaliplatin 0 1
Epcoritamab-bysp + Ibrutinib + Lenalidomide Epcoritamab-bysp Ibrutinib Lenalidomide 0 1
Epcoritamab-bysp + Lenalidomide Epcoritamab-bysp Lenalidomide 0 3
Epcoritamab-bysp + Lenalidomide + Rituximab Epcoritamab-bysp Lenalidomide Rituximab 0 2
Epcoritamab-bysp + Rituximab Epcoritamab-bysp Rituximab 0 1


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