Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name AZD5305
Trade Name
Synonyms AZD 5305|AZD-5305
Drug Descriptions

AZD5305 inhibits PARP1, potentially inhibiting cell growth and inducing tumor regression (PMID: 35929986).

DrugClasses PARP-1 Inhibitor 9
CAS Registry Number NA
NCIT ID C176783


  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")


  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Abiraterone + AZD5305 AZD5305 Abiraterone 0 2
AZD5305 AZD5305 0 2
AZD5305 + AZD5335 AZD5305 AZD5335 0 1
AZD5305 + AZD8205 AZD5305 AZD8205 0 0
AZD5305 + Camizestrant AZD5305 Camizestrant 0 1
AZD5305 + Carboplatin AZD5305 Carboplatin 0 1
AZD5305 + Carboplatin + Datopotamab deruxtecan AZD5305 Carboplatin Datopotamab deruxtecan 0 0
AZD5305 + Carboplatin + Paclitaxel AZD5305 Carboplatin Paclitaxel 0 1
AZD5305 + Cisplatin AZD5305 Cisplatin 0 0
AZD5305 + Darolutamide AZD5305 Darolutamide 0 3
AZD5305 + Datopotamab deruxtecan AZD5305 Datopotamab deruxtecan 0 1
AZD5305 + Datopotamab deruxtecan + Durvalumab AZD5305 Datopotamab deruxtecan Durvalumab 0 1
AZD5305 + Enzalutamide AZD5305 Enzalutamide 0 2
AZD5305 + Paclitaxel AZD5305 Paclitaxel 0 1

Additional content available in CKB BOOST