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BLU-701 is a reversible EGFR inhibitor that blocks the activity of mutant forms of EGFR, including C797S, while sparing wild-type EGFR, which results in reduced downstream signaling and potentially leads to decreased tumor growth (Cancer Res 2021;81(13_Suppl):Abstract nr 1262).
|DrugClasses||EGFR Inhibitor 4th gen 12|
|CAS Registry Number||NA|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|BLU-701 + Carboplatin + Pemetrexed Disodium||BLU-701 Carboplatin Pemetrexed Disodium||0||1|
|BLU-701 + Osimertinib||BLU-701 Osimertinib||0||1|