Drug Detail


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Drug Name RLY-2608
Trade Name
Synonyms RLY 2608|RLY2608
Drug Descriptions

RLY-2608 selectively inhibits PIK3CA with higher selectivity and potency against mutant forms of PIK3CA (including PIK3CA E542K, PIK3CA E545K, and PIK3CA H1047R), leading to decreased downstream signaling, and potentially resulting in reduced tumor cell viability and tumor growth (Mol Cancer Ther 2021;20(12 Suppl):Abstract nr P251).

DrugClasses PIK3CA inhibitor 23
CAS Registry Number NA
NCIT ID C186533


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Fulvestrant + Ribociclib + RLY-2608 Fulvestrant RLY-2608 Ribociclib 0 0
Fulvestrant + RLY-2608 Fulvestrant RLY-2608 0 1
RLY-2608 RLY-2608 10 1

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