Drug Detail


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Drug Name BGB-A445
Trade Name
Synonyms BGB A445|BGBA445
Drug Descriptions

BGB-A445 is an activating anti-TNFRSF4 (OX40) antibody that does not block binding to its ligand, OX40L, potentially resulting in increased immune response and anti-tumor activity (Journal for ImmunoTherapy of Cancer 2020;8:699).

DrugClasses OX40 Antibody 14
CAS Registry Number NA
NCIT ID C175453


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Therapy Name Drugs Efficacy Evidence Clinical Trials
BGB-A445 BGB-A445 0 1
BGB-A445 + Carboplatin + Tislelizumab BGB-A445 Carboplatin Tislelizumab 0 0
BGB-A445 + Cisplatin + Tislelizumab BGB-A445 Cisplatin Tislelizumab 0 0
BGB-A445 + Nab-paclitaxel + Tislelizumab BGB-A445 Nab-paclitaxel Tislelizumab 0 0
BGB-A445 + Paclitaxel + Tislelizumab BGB-A445 Paclitaxel Tislelizumab 0 0
BGB-A445 + Pemetrexed Disodium + Tislelizumab BGB-A445 Pemetrexed Disodium Tislelizumab 0 0
BGB-A445 + Tislelizumab BGB-A445 Tislelizumab 0 2

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