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Drug Name AMG193
Trade Name
Synonyms AMG-193|AMG 193
Drug Descriptions

AMG193 inhibits protein arginine methyltransferase 5 (PRMT5), potentially leading to inhibition of tumor cell proliferation (NCI Drug Dictionary).

DrugClasses PRMT5 Inhibitor 16
CAS Registry Number NA
NCIT ID C185417

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Therapy Name Drugs Efficacy Evidence Clinical Trials
AMG193 AMG193 0 2
AMG193 + Carboplatin + Paclitaxel + Pembrolizumab AMG193 Carboplatin Paclitaxel Pembrolizumab 0 1
AMG193 + Carboplatin + Pembrolizumab + Pemetrexed Disodium AMG193 Carboplatin Pembrolizumab Pemetrexed Disodium 0 1
AMG193 + Cisplatin + Gemcitabine + Pembrolizumab AMG193 Cisplatin Gemcitabine Pembrolizumab 0 1
AMG193 + Docetaxel AMG193 Docetaxel 0 1
AMG193 + Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin AMG193 Fluorouracil Irinotecan Leucovorin Oxaliplatin 0 1
AMG193 + Gemcitabine + Nab-paclitaxel AMG193 Gemcitabine Nab-paclitaxel 0 1
AMG193 + IDE397 AMG193 IDE397 0 1
AMG193 + Pembrolizumab AMG193 Pembrolizumab 0 1
AMG193 + Sotorasib AMG193 Sotorasib 0 1


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