Drug Detail


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Drug Name SOT102
Trade Name
Synonyms SOT-102|SOT 102|SO N102|SO-N102|SON102
Drug Descriptions

SOT102 is an antibody-drug conjugate (ADC) comprising a claudin 18.2 (CLDN18.2)-targeted antibody linked to a derivative of the cytotoxic anthracycline PNU-159682, which potentially leads to impaired DNA replication and protein synthesis, resulting in killing of tumor cells expressing CLDN18.2 (NCI Drug Dictionary).

DrugClasses CLDN18.2 Antibody 18
CAS Registry Number NA
NCIT ID C190788


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Fluorouracil + Leucovorin + Nivolumab + Oxaliplatin + SOT102 Fluorouracil Leucovorin Nivolumab Oxaliplatin SOT102 0 1
Gemcitabine + Nab-paclitaxel + SOT102 Gemcitabine Nab-paclitaxel SOT102 0 1
SOT102 SOT102 0 1

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