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Drug Name | Zebularine |
Trade Name | |
Synonyms | 1-beta-D-ribofuranosyl-2(1H)-pyrimidinone |
Drug Descriptions |
Zebularine is a cytidine analog that is incorporated into DNA and forms a complex with DNA methyltransferases, resulting in decreased DNA methylation and potentially leading to activation of silenced tumor suppressor genes and decreased tumor cell growth (PMID: 16239434, PMID: 15324698, PMID: 19138966). |
DrugClasses | DNMT inhibitor (Pan) 5 |
CAS Registry Number | 3690-10-6 |
NCIT ID | C37455 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Zebularine | Zebularine | 0 | 0 |