Drug Detail


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Drug Name Bosutinib
Trade Name Bosulif
Synonyms SKI-606|PF-5208763
Drug Descriptions

Bosulif (bosutinib) inhibits SRC and ABL kinases and has additional activity against other kinases including AXL, TNK2, and BTK, resulting in decreased pathway activation and inhibition of tumor cell proliferation (PMID: 12543790, PMID: 19039322, PMID: 26555154). Bosulif (bosutinib) is FDA-approved for use in adult and pediatric patients 1 year of age and older with Ph+ (BCR-ABL) chronic myelogenous leukemia (FDA.gov).

DrugClasses ABL Inhibitor (pan) 9 AXL Inhibitor 29 BCR-ABL Inhibitor 30 BTK inhibitor 35 SRC Inhibitor 31 TNK2 Inhibitor 6
CAS Registry Number 380843-75-4
NCIT ID C60809


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Atezolizumab + Bosutinib Atezolizumab Bosutinib 0 1
Axitinib + Bosutinib Axitinib Bosutinib 0 1
Bosutinib Bosutinib 1 12
Bosutinib + Cisplatin Bosutinib Cisplatin 0 0
Bosutinib + Fulvestrant + Palbociclib Bosutinib Fulvestrant Palbociclib 0 1
Bosutinib + Gemcitabine Bosutinib Gemcitabine 0 0
Bosutinib + Glasdegib Bosutinib Glasdegib 0 1
Bosutinib + Inotuzumab ozogamicin Bosutinib Inotuzumab ozogamicin 0 1
Bosutinib + Osimertinib Bosutinib Osimertinib 0 0
Bosutinib + Osimertinib + PF-573228 Bosutinib Osimertinib PF-573228 0 0
Bosutinib + Palbociclib Bosutinib Palbociclib 0 1
Bosutinib + Pemetrexed Disodium Bosutinib Pemetrexed Disodium 0 1
Bosutinib + Rociletinib Bosutinib Rociletinib 0 0
Bosutinib + Ruxolitinib Bosutinib Ruxolitinib 0 2
Bosutinib + SHP099 Bosutinib SHP099 0 0
Bosutinib + TAK-632 Bosutinib TAK-632 0 0
Bosutinib + Vemurafenib Bosutinib Vemurafenib 1 0

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