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| Drug Name | Bosutinib |
| Trade Name | Bosulif |
| Synonyms | SKI-606|PF-5208763 |
| Drug Descriptions |
Bosulif (bosutinib) inhibits SRC and ABL kinases and has additional activity against other kinases including AXL, TNK2, and BTK, resulting in decreased pathway activation and inhibition of tumor cell proliferation (PMID: 12543790, PMID: 19039322, PMID: 26555154). Bosulif (bosutinib) is FDA-approved for use in adult and pediatric patients 1 year of age and older with Ph+ (BCR-ABL) chronic myelogenous leukemia (FDA.gov). |
| DrugClasses | ABL Inhibitor (pan) 9 AXL Inhibitor 29 BCR-ABL Inhibitor 30 BTK inhibitor 35 SRC Inhibitor 31 TNK2 Inhibitor 6 |
| CAS Registry Number | 380843-75-4 |
| NCIT ID | C60809 |
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