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| Drug Name | Bosutinib |
| Trade Name | Bosulif |
| Synonyms | SKI-606|PF-5208763 |
| Drug Descriptions |
Bosulif (bosutinib) inhibits SRC and ABL kinases, and has additional activity against other kinases including AXL, TNK2, BTK, resulting in decreased pathway activation and inhibition of tumor cell proliferation (PMID: 12543790, PMID: 19039322, PMID: 26555154). Bosulif (bosutinib) is FDA approved for use in patients with Ph+ (BCR-ABL) chronic myelogenous leukemia (FDA.gov). |
| DrugClasses | ABL Inhibitor (pan) 9 AXL Inhibitor 28 BCR-ABL Inhibitor 28 BTK inhibitor 32 SRC Inhibitor 31 TNK2 Inhibitor 6 |
| CAS Registry Number | 380843-75-4 |
| NCIT ID | C60809 |
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