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Drug Name Bosutinib
Trade Name Bosulif
Synonyms SKI-606|PF-5208763
Drug Descriptions

Bosulif (bosutinib) inhibits SRC and ABL kinases, and has additional activity against other kinases including AXL, TNK2, BTK, resulting in decreased pathway activation and inhibition of tumor cell proliferation (PMID: 12543790, PMID: 19039322, PMID: 26555154). Bosulif (bosutinib) is FDA approved for use in patients with Ph+ (BCR-ABL) chronic myelogenous leukemia (FDA.gov).

DrugClasses ABL Inhibitor (pan) 8 AXL Inhibitor 27 BTK inhibitor 22 SRC Inhibitor 28 TNK2 Inhibitor 6

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Axitinib + Bosutinib Axitinib Bosutinib 0 1
Bosutinib Bosutinib 4 8
Bosutinib + Cisplatin Bosutinib Cisplatin 1 0
Bosutinib + Fulvestrant + Palbociclib Bosutinib Fulvestrant Palbociclib 0 1
Bosutinib + Gemcitabine Bosutinib Gemcitabine 1 0
Bosutinib + Inotuzumab ozogamicin Bosutinib Inotuzumab ozogamicin 0 1
Bosutinib + Osimertinib + PF-573228 Bosutinib Osimertinib PF-573228 0 0
Bosutinib + Palbociclib Bosutinib Palbociclib 0 1
Bosutinib + Pemetrexed Disodium Bosutinib Pemetrexed Disodium 0 1
Bosutinib + Ruxolitinib Bosutinib Ruxolitinib 0 1


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