Drug Detail


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Drug Name Vismodegib
Trade Name Erivedge
Synonyms GDC-0449
Drug Descriptions

Erivedge (vismodegib) binds to and inhibits Smoothened (SMO), resulting in inhibition of downstream signaling and decreased tumor growth (PMID: 24259609, PMID: 19716296). Erivedge (vismodegib) is FDA approved for use in patients with basal cell carcinoma (FDA.gov).

DrugClasses SMO Inhibitor 16
CAS Registry Number 879085-55-9
NCIT ID C74038


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Therapy Name Drugs Efficacy Evidence Clinical Trials
A769662 + Vismodegib A769662 Vismodegib 0 0
Cytarabine + Vismodegib Cytarabine Vismodegib 0 1
Gemcitabine + Nab-paclitaxel + Vismodegib Gemcitabine Nab-paclitaxel Vismodegib 0 1
Metformin + Vismodegib Metformin Vismodegib 0 0
Pembrolizumab + Vismodegib Pembrolizumab Vismodegib 0 1
Posaconazole + Vismodegib Posaconazole Vismodegib 0 0
Ribavirin + Vismodegib Ribavirin Vismodegib 0 1
RO4929097 + Vismodegib RO4929097 Vismodegib 0 1
Sirolimus + Vismodegib Sirolimus Vismodegib 0 1
Vismodegib Vismodegib 0 24

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