Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Amuvatinib
Trade Name
Synonyms MP470|HPK56|MP-470
Drug Descriptions

Amuvatinib (MP470) is a multi-kinase inhibitor, with activity against KIT, MET, AXL, RET, FLT3, and PDGFR-alpha, that also inhibits Rad51 induction, which may enhance the efficacy of chemotherapeutic agents (PMID: 17325667, PMID: 21903282, PMID: 20563581, PMID: 24849582).

DrugClasses AXL Inhibitor 28 FLT3 Inhibitor 61 KIT Inhibitor 53 MET Inhibitor 56 PDGFR-alpha Inhibitor 9 RET Inhibitor 47
CAS Registry Number 850879-09-3
NCIT ID C71750


  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"


  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Amuvatinib Amuvatinib 0 0
Amuvatinib + Carboplatin + Paclitaxel Amuvatinib Carboplatin Paclitaxel 0 0

Additional content available in CKB BOOST